Synthetic heparinoids labelled with 125I and 35S

L.C. Sederel, Z. Kolar, L. van der Does, A. Bantjes

Research output: Contribution to journalArticleAcademic

3 Citations (Scopus)
77 Downloads (Pure)

Abstract

The labelling of a water-soluble synthetic polyelectrolyte, having anticoagulant activity, has been studied. The polyelectrolyte is derived from cis-1,4-polyisoprene and contains N-sulfate and carboxylate groups. [125I]-Iodination of the polyelectrolyte, using the Chloramine-T method and an electrolytic method, resulted in a [125I]-labelled polyelectrolyte from which release of the label occurred. Resulfation of a partially desulfated polyelectrolyte with a [35S]-sulfur trioxide trimethylamine complex resulted in a [35S]-labelled polyelectrolyte which showed no release of the label.
Original languageEnglish
Pages (from-to)1251-1263
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume19
Issue number10
DOIs
Publication statusPublished - 1982

Keywords

  • IR-70711
  • Anticoagulant
  • Polyelectrolyte
  • Radiolabelling
  • Heparinoid

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