Tablet and web-based audiometry to screen for hearing loss in adults with cystic fibrosis

Anitha Vijayasingam, Emily Frost, Julie Wilkins, Lise Gillen, Presanna Premachandra, Kate McLaren, Desmond Gilmartin, Lorenzo Picinali, Alberto Vidal-Diez, Simone Borsci, Melody Zhifang Ni, Wai Y. Tang, Deborah Morris-Rosendahl, Jonny Harcourt, Caroline Elston, N. J. Simmonds, Anand Shah*

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    9 Citations (Scopus)
    3 Downloads (Pure)

    Abstract

    Introduction: Individuals with chronic lung disease (eg, cystic fibrosis (CF)) often receive antimicrobial therapy including aminoglycosides resulting in ototoxicity. Extended high-frequency audiometry has increased sensitivity for ototoxicity detection, but diagnostic audiometry in a sound-booth is costly, time-consuming and requires a trained audiologist. This cross-sectional study analysed tablet-based audiometry (Shoebox MD) performed by non-audiologists in an outpatient setting, alongside home web-based audiometry (3D Tune-In) to screen for hearing loss in adults with CF. Methods: Hearing was analysed in 126 CF adults using validated questionnaires, a web self-hearing test (0.5 to 4 kHz), tablet (0.25 to 12 kHz) and sound-booth audiometry (0.25 to 12 kHz). A threshold of ≥25 dB hearing loss at ≥1 audiometric frequency was considered abnormal. Demographics and mitochondrial DNA sequencing were used to analyse risk factors, and accuracy and usability of hearing tests determined. Results: Prevalence of hearing loss within any frequency band tested was 48%. Multivariate analysis showed age (OR 1.127; (95% CI: 1.07 to 1.18; p value<0.0001) per year older) and total intravenous antibiotic days over 10 years (OR 1.006; (95% CI: 1.002 to 1.010; p value=0.004) per further intravenous day) were significantly associated with increased risk of hearing loss. Tablet audiometry had good usability, was 93% sensitive, 88% specific with 94% negative predictive value to screen for hearing loss compared with web self-test audiometry and questionnaires which had poor sensitivity (17% and 13%, respectively). Intraclass correlation (ICC) of tablet versus sound-booth audiometry showed high correlation (ICC >0.9) at all frequencies ≥4 kHz. Conclusions: Adults with CF have a high prevalence of drug-related hearing loss and tablet-based audiometry can be a practical, accurate screening tool within integrated ototoxicity monitoring programmes for early detection.

    Original languageEnglish
    Article number214177
    Pages (from-to)632-639
    Number of pages8
    JournalThorax
    Volume75
    Issue number8
    Early online date14 May 2020
    DOIs
    Publication statusPublished - 1 Aug 2020

    Keywords

    • Cystic fibrosis
    • respiratory Infection
    • systemic disease and lungs
    • 22/2 OA procedure

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