– The Casimir interaction is omnipresent source of forces at small separations between bodies, which is difficult to change by varying external conditions. Here we show that graphene interacting with a metal can have the best known force contrast to the temperature and the Fermi level variations. In the distance range 50–300nm the force is measurable and can vary a few times for graphene with a bandgap much larger than the temperature. In this distance range the main part of the force is due to the thermal fluctuations. We discuss also graphene on a dielectric membrane as a technologically robust configuration.