Targeted brain activation using an MR-compatible wrist torque measurement device and isometric motor tasks during functional magnetic resonance imaging

Martijn P. Vlaar, Winfred Mugge, Paul F.C. Groot, Shahriar Sharifi, Lo J. Bour, Frans C.T. van der Helm, Anne-Fleur van Rootselaar, Alfred C. Schouten

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

Dedicated pairs of isometric wrist flexion tasks, with and without visual feedback of the exerted torque, were designed to target activation of the CBL and BG in healthy subjects during functional magnetic resonance imaging (fMRI). Selective activation of the cerebellum (CBL) and basal ganglia (BG), often implicated in movement disorders such as tremor and dystonia, may help identify pathological changes and expedite diagnosis. A prototyped MR-compatible wrist torque measurement device, free of magnetic and conductive materials, allowed safe execution of tasks during fMRI without causing artifacts. A significant increase of activity in CBL and BG was found in healthy volunteers during a constant torque task with visual feedback compared to a constant torque task without visual feedback. This study shows that specific pairs of motor tasks using MR-compatible equipment at the wrist allow for targeted activation of CBL and BG, paving a new way for research into the pathophysiology of movement disorders.
Original languageEnglish
Pages (from-to)795-802
Number of pages8
JournalMagnetic resonance imaging
Volume34
Issue number6
DOIs
Publication statusPublished - 2016

Fingerprint

Torque measurement
Torque
Basal Ganglia
Wrist
Cerebellum
Sensory Feedback
Brain
Chemical activation
Magnetic Resonance Imaging
Feedback
Equipment and Supplies
Movement Disorders
Conductive materials
Healthy Volunteers
Magnetic materials
Dystonia
Tremor
Artifacts
Research

Keywords

  • METIS-317870
  • IR-104324

Cite this

Vlaar, Martijn P. ; Mugge, Winfred ; Groot, Paul F.C. ; Sharifi, Shahriar ; Bour, Lo J. ; van der Helm, Frans C.T. ; van Rootselaar, Anne-Fleur ; Schouten, Alfred C. / Targeted brain activation using an MR-compatible wrist torque measurement device and isometric motor tasks during functional magnetic resonance imaging. In: Magnetic resonance imaging. 2016 ; Vol. 34, No. 6. pp. 795-802.
@article{2b7c7b20bf3a40598001166324bacfe4,
title = "Targeted brain activation using an MR-compatible wrist torque measurement device and isometric motor tasks during functional magnetic resonance imaging",
abstract = "Dedicated pairs of isometric wrist flexion tasks, with and without visual feedback of the exerted torque, were designed to target activation of the CBL and BG in healthy subjects during functional magnetic resonance imaging (fMRI). Selective activation of the cerebellum (CBL) and basal ganglia (BG), often implicated in movement disorders such as tremor and dystonia, may help identify pathological changes and expedite diagnosis. A prototyped MR-compatible wrist torque measurement device, free of magnetic and conductive materials, allowed safe execution of tasks during fMRI without causing artifacts. A significant increase of activity in CBL and BG was found in healthy volunteers during a constant torque task with visual feedback compared to a constant torque task without visual feedback. This study shows that specific pairs of motor tasks using MR-compatible equipment at the wrist allow for targeted activation of CBL and BG, paving a new way for research into the pathophysiology of movement disorders.",
keywords = "METIS-317870, IR-104324",
author = "Vlaar, {Martijn P.} and Winfred Mugge and Groot, {Paul F.C.} and Shahriar Sharifi and Bour, {Lo J.} and {van der Helm}, {Frans C.T.} and {van Rootselaar}, Anne-Fleur and Schouten, {Alfred C.}",
year = "2016",
doi = "10.1016/j.mri.2016.02.002",
language = "English",
volume = "34",
pages = "795--802",
journal = "Magnetic resonance imaging",
issn = "0730-725X",
publisher = "Elsevier",
number = "6",

}

Targeted brain activation using an MR-compatible wrist torque measurement device and isometric motor tasks during functional magnetic resonance imaging. / Vlaar, Martijn P.; Mugge, Winfred; Groot, Paul F.C.; Sharifi, Shahriar; Bour, Lo J.; van der Helm, Frans C.T.; van Rootselaar, Anne-Fleur; Schouten, Alfred C.

In: Magnetic resonance imaging, Vol. 34, No. 6, 2016, p. 795-802.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Targeted brain activation using an MR-compatible wrist torque measurement device and isometric motor tasks during functional magnetic resonance imaging

AU - Vlaar, Martijn P.

AU - Mugge, Winfred

AU - Groot, Paul F.C.

AU - Sharifi, Shahriar

AU - Bour, Lo J.

AU - van der Helm, Frans C.T.

AU - van Rootselaar, Anne-Fleur

AU - Schouten, Alfred C.

PY - 2016

Y1 - 2016

N2 - Dedicated pairs of isometric wrist flexion tasks, with and without visual feedback of the exerted torque, were designed to target activation of the CBL and BG in healthy subjects during functional magnetic resonance imaging (fMRI). Selective activation of the cerebellum (CBL) and basal ganglia (BG), often implicated in movement disorders such as tremor and dystonia, may help identify pathological changes and expedite diagnosis. A prototyped MR-compatible wrist torque measurement device, free of magnetic and conductive materials, allowed safe execution of tasks during fMRI without causing artifacts. A significant increase of activity in CBL and BG was found in healthy volunteers during a constant torque task with visual feedback compared to a constant torque task without visual feedback. This study shows that specific pairs of motor tasks using MR-compatible equipment at the wrist allow for targeted activation of CBL and BG, paving a new way for research into the pathophysiology of movement disorders.

AB - Dedicated pairs of isometric wrist flexion tasks, with and without visual feedback of the exerted torque, were designed to target activation of the CBL and BG in healthy subjects during functional magnetic resonance imaging (fMRI). Selective activation of the cerebellum (CBL) and basal ganglia (BG), often implicated in movement disorders such as tremor and dystonia, may help identify pathological changes and expedite diagnosis. A prototyped MR-compatible wrist torque measurement device, free of magnetic and conductive materials, allowed safe execution of tasks during fMRI without causing artifacts. A significant increase of activity in CBL and BG was found in healthy volunteers during a constant torque task with visual feedback compared to a constant torque task without visual feedback. This study shows that specific pairs of motor tasks using MR-compatible equipment at the wrist allow for targeted activation of CBL and BG, paving a new way for research into the pathophysiology of movement disorders.

KW - METIS-317870

KW - IR-104324

U2 - 10.1016/j.mri.2016.02.002

DO - 10.1016/j.mri.2016.02.002

M3 - Article

VL - 34

SP - 795

EP - 802

JO - Magnetic resonance imaging

JF - Magnetic resonance imaging

SN - 0730-725X

IS - 6

ER -