Targeted LipoCEST contrast agents for magnetic resonance imaging: Alignment of aspherical liposomes on a capillary surface

Dirk Burdinski*, Jeroen A. Pikkemaat, Mustafa Emrullahoglu, Francesca Costantini, Willem Verboom, Sander Langereis, Holger Grüll, Jurriaan Huskens

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Abstract

"Chemical Equation Presented" Searching for orientation: The alignment of aspherical paramagnetic liposomes in a magnetic field makes them attractive contrast agents for magnetic resonance (MR) imaging. The orientation of aspher-ical liposomes in solution, and the orientation change upon binding to a target surface was determined by using a simple MR technique (see picture).

Original languageEnglish
Pages (from-to)2227-2229
Number of pages3
JournalAngewandte Chemie - International Edition
Volume49
Issue number12
DOIs
Publication statusPublished - 15 Mar 2010

    Fingerprint

Keywords

  • Chemical exchange saturation transfer (CEST)
  • Diagnostic agents
  • Liposomes
  • Multivalency
  • NMR imaging

Cite this