Targeting iron metabolism in drug discovery and delivery

Bart J. Crielaard*, Twan Lammers, Stefano Rivella

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

155 Citations (Scopus)
181 Downloads (Pure)


Iron fulfils a central role in many essential biochemical processes in human physiology; thus, proper processing of iron is crucial. Although iron metabolism is subject to relatively strict physiological control, numerous disorders, such as cancer and neurodegenerative diseases, have recently been linked to deregulated iron homeostasis. Consequently, iron metabolism constitutes a promising and largely unexploited therapeutic target for the development of new pharmacological treatments for these diseases. Several iron metabolism-targeted therapies are already under clinical evaluation for haematological disorders, and these and newly developed therapeutic agents are likely to have substantial benefit in the clinical management of iron metabolism-associated diseases, for which few efficacious treatments are currently available.

Original languageEnglish
Pages (from-to)400-423
Number of pages24
JournalNature Reviews Drug Discovery
Issue number6
Publication statusPublished - 1 Jun 2017


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