Targeting protein-loaded CB[8]-mediated supramolecular nanocarriers to cells

Emanuela Cavatorta, Jens Voskuhl, Dorothee Wasserberg, Jenny Brinkmann, Jurriaan Huskens*, Pascal Jonkheijm

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Supramolecular amphiphiles, consisting of ternary complexes of cucurbit[8]uril (CB[8]), an alkylated paraquat derivative and a tetraethylene glycol-functionalized azobenzene, self-assemble into vesicles of about 200 nm in diameter. The outer surface of the vesicles was functionalized with cell-targeting ligands. These vesicles were employed for loading and delivery of proteins into cells. Supramolecular amphiphile-derived vesicles show great promise as nanocarriers of functional molecules to be transferred into cells.

Original languageEnglish
Pages (from-to)54341-54346
Number of pages6
JournalRSC advances
Volume7
Issue number86
DOIs
Publication statusPublished - 2017

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