Templated Formation of Luminescent Virus-like Particles by Tailor-Made Pt(II) Amphiphiles

Stephan Sinn, Liulin Yang, Frank Biedermann, Di Wang, Christian Kübel, Jeroen J.L.M. Cornelissen* (Corresponding Author), Luisa De Cola (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

33 Citations (Scopus)
61 Downloads (Pure)

Abstract

Virus-like particles (VLPs) have been created from luminescent Pt(II) complex amphiphiles, able to form supramolecular structures in water solutions, that can be encapsulated or act as templates of cowpea chlorotic mottle virus capsid proteins. By virtue of a bottom-up molecular design, icosahedral and nonicosahedral (rod-like) VLPs have been constructed through diverse pathways, and a relationship between the molecular structure of the complexes and the shape and size of the VLPs has been observed. A deep insight into the mechanism for the templated formation of the differently shaped VLPs was achieved, by electron microscopy measurements (TEM and STEM) and bulk analysis (FPLC, DLS, photophysical investigations). Interestingly, the obtained VLPs can be visualized by their intense emission at room temperature, generated by the self-assembly of the Pt(II) complexes. The encapsulation of the luminescent species is further verified by their higher emission quantum yields inside the VLPs, which is due to the confinement effect of the protein cage. These hybrid materials demonstrate the potential of tailor-made supramolecular systems able to control the assembly of biological building blocks.

Original languageEnglish
Pages (from-to)2355-2362
Number of pages8
JournalJournal of the American Chemical Society
Volume140
Issue number6
DOIs
Publication statusPublished - 14 Feb 2018

Keywords

  • UT-Hybrid-D

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