TY - JOUR
T1 - Templated Formation of Luminescent Virus-like Particles by Tailor-Made Pt(II) Amphiphiles
AU - Sinn, Stephan
AU - Yang, Liulin
AU - Biedermann, Frank
AU - Wang, Di
AU - Kübel, Christian
AU - Cornelissen, Jeroen J.L.M.
AU - De Cola, Luisa
N1 - ACS deal
PY - 2018/2/14
Y1 - 2018/2/14
N2 - Virus-like particles (VLPs) have been created from luminescent Pt(II) complex amphiphiles, able to form supramolecular structures in water solutions, that can be encapsulated or act as templates of cowpea chlorotic mottle virus capsid proteins. By virtue of a bottom-up molecular design, icosahedral and nonicosahedral (rod-like) VLPs have been constructed through diverse pathways, and a relationship between the molecular structure of the complexes and the shape and size of the VLPs has been observed. A deep insight into the mechanism for the templated formation of the differently shaped VLPs was achieved, by electron microscopy measurements (TEM and STEM) and bulk analysis (FPLC, DLS, photophysical investigations). Interestingly, the obtained VLPs can be visualized by their intense emission at room temperature, generated by the self-assembly of the Pt(II) complexes. The encapsulation of the luminescent species is further verified by their higher emission quantum yields inside the VLPs, which is due to the confinement effect of the protein cage. These hybrid materials demonstrate the potential of tailor-made supramolecular systems able to control the assembly of biological building blocks.
AB - Virus-like particles (VLPs) have been created from luminescent Pt(II) complex amphiphiles, able to form supramolecular structures in water solutions, that can be encapsulated or act as templates of cowpea chlorotic mottle virus capsid proteins. By virtue of a bottom-up molecular design, icosahedral and nonicosahedral (rod-like) VLPs have been constructed through diverse pathways, and a relationship between the molecular structure of the complexes and the shape and size of the VLPs has been observed. A deep insight into the mechanism for the templated formation of the differently shaped VLPs was achieved, by electron microscopy measurements (TEM and STEM) and bulk analysis (FPLC, DLS, photophysical investigations). Interestingly, the obtained VLPs can be visualized by their intense emission at room temperature, generated by the self-assembly of the Pt(II) complexes. The encapsulation of the luminescent species is further verified by their higher emission quantum yields inside the VLPs, which is due to the confinement effect of the protein cage. These hybrid materials demonstrate the potential of tailor-made supramolecular systems able to control the assembly of biological building blocks.
KW - UT-Hybrid-D
UR - http://www.scopus.com/inward/record.url?scp=85042014571&partnerID=8YFLogxK
U2 - 10.1021/jacs.7b12447
DO - 10.1021/jacs.7b12447
M3 - Article
AN - SCOPUS:85042014571
SN - 0002-7863
VL - 140
SP - 2355
EP - 2362
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 6
ER -