The −589C>T polymorphism in the interleukin-4 gene (IL-4) is associated with a reduced risk of myocardial infarction in young individuals

E. Paffen; P. Medina; M.C.H. de Visser; A. van Wijngaarden; E. Zorio; A. Estelles; F.R. Rosendaal; F. Espana; R.M. Bertina; C.J.M. Doggen

doi:10.1111/j.1538-7836.2008.03096.x

The −589C>T polymorphism in the interleukin-4 gene (IL-4) is associated with a reduced risk of myocardial infarction in young individuals

E. Paffen, P. Medina, M.C.H. de Visser, A. van Wijngaarden, E. Zorio, A. Estelles, F.R. Rosendaal, F. Espana, R.M. Bertina, C.J.M. Doggen

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Abstract

Background: Inflammatory reactions contribute to the development of arterial disease. We investigated the role of interleukin-4 (IL-4) in the development of myocardial infarction (MI) by genotyping patients with MI and control subjects for the −589C>T (rs2243250) single nucleotide polymorphism (SNP), which tags a functional haplotype of IL-4.

Methods and results: Study of Myocardial Infarctions Leiden (SMILE) included 560 men with a first MI and 646 control subjects. The Valencia study included 305 patients with MI at ≤52 years (men and women) and 310 control subjects. In SMILE no clear overall association with the −589C>T genotype was found [odds ratio (OR) 0.84; 95% CI 0.37–1.95 for −589TT and 0.82; 95% CI 0.62–1.07 for −589CT compared with −589CC]. In patients younger than 50 years, carriership of one or two −589T alleles was associated with a reduced risk of MI (OR 0.57: 95% CI 0.34–0.95). This result was replicated in the Valencia study, where carriers of one or two −589T alleles had a reduced risk of MI (OR 0.67: 95% CI 0.47–0.95), with a strong protective effect of the −598T allele in homozygous −589T (OR 0.33: 95% CI 0.10–1.05). In the control subjects of the Valencia study, the −589T allele was associated with reduced levels of F1+2.

Conclusion: Our data indicate that the IL-4 haplotype tagged by the −589T allele reduces the risk of MI in young individuals.

Original language	English
Pages (from-to)	1633-1638
Journal	Journal of thrombosis and haemostasis
Volume	6
Issue number	10
DOIs	https://doi.org/10.1111/j.1538-7836.2008.03096.x
Publication status	Published - 2008
Externally published	Yes

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Paffen, E., Medina, P., de Visser, M. C. H., van Wijngaarden, A., Zorio, E., Estelles, A., Rosendaal, F. R., Espana, F., Bertina, R. M., & Doggen, C. J. M. (2008). The −589C>T polymorphism in the interleukin-4 gene (IL-4) is associated with a reduced risk of myocardial infarction in young individuals. Journal of thrombosis and haemostasis, 6(10), 1633-1638. https://doi.org/10.1111/j.1538-7836.2008.03096.x

@article{72f7192bc7f046759ca8147ce9e269f6,

title = "The −589C>T polymorphism in the interleukin-4 gene (IL-4) is associated with a reduced risk of myocardial infarction in young individuals",

abstract = "Background: Inflammatory reactions contribute to the development of arterial disease. We investigated the role of interleukin-4 (IL-4) in the development of myocardial infarction (MI) by genotyping patients with MI and control subjects for the −589C>T (rs2243250) single nucleotide polymorphism (SNP), which tags a functional haplotype of IL-4.Methods and results: Study of Myocardial Infarctions Leiden (SMILE) included 560 men with a first MI and 646 control subjects. The Valencia study included 305 patients with MI at ≤52 years (men and women) and 310 control subjects. In SMILE no clear overall association with the −589C>T genotype was found [odds ratio (OR) 0.84; 95% CI 0.37–1.95 for −589TT and 0.82; 95% CI 0.62–1.07 for −589CT compared with −589CC]. In patients younger than 50 years, carriership of one or two −589T alleles was associated with a reduced risk of MI (OR 0.57: 95% CI 0.34–0.95). This result was replicated in the Valencia study, where carriers of one or two −589T alleles had a reduced risk of MI (OR 0.67: 95% CI 0.47–0.95), with a strong protective effect of the −598T allele in homozygous −589T (OR 0.33: 95% CI 0.10–1.05). In the control subjects of the Valencia study, the −589T allele was associated with reduced levels of F1+2.Conclusion: Our data indicate that the IL-4 haplotype tagged by the −589T allele reduces the risk of MI in young individuals.",

author = "E. Paffen and P. Medina and {de Visser}, M.C.H. and {van Wijngaarden}, A. and E. Zorio and A. Estelles and F.R. Rosendaal and F. Espana and R.M. Bertina and C.J.M. Doggen",

year = "2008",

doi = "10.1111/j.1538-7836.2008.03096.x",

language = "English",

volume = "6",

pages = "1633--1638",

journal = "Journal of thrombosis and haemostasis",

issn = "1538-7933",

publisher = "Wiley-Blackwell",

number = "10",

}

Paffen, E, Medina, P, de Visser, MCH, van Wijngaarden, A, Zorio, E, Estelles, A, Rosendaal, FR, Espana, F, Bertina, RM & Doggen, CJM 2008, 'The −589C>T polymorphism in the interleukin-4 gene (IL-4) is associated with a reduced risk of myocardial infarction in young individuals', Journal of thrombosis and haemostasis, vol. 6, no. 10, pp. 1633-1638. https://doi.org/10.1111/j.1538-7836.2008.03096.x

TY - JOUR

T1 - The −589C>T polymorphism in the interleukin-4 gene (IL-4) is associated with a reduced risk of myocardial infarction in young individuals

AU - Paffen, E.

AU - Medina, P.

AU - de Visser, M.C.H.

AU - van Wijngaarden, A.

AU - Zorio, E.

AU - Estelles, A.

AU - Rosendaal, F.R.

AU - Espana, F.

AU - Bertina, R.M.

AU - Doggen, C.J.M.

PY - 2008

Y1 - 2008

N2 - Background: Inflammatory reactions contribute to the development of arterial disease. We investigated the role of interleukin-4 (IL-4) in the development of myocardial infarction (MI) by genotyping patients with MI and control subjects for the −589C>T (rs2243250) single nucleotide polymorphism (SNP), which tags a functional haplotype of IL-4.Methods and results: Study of Myocardial Infarctions Leiden (SMILE) included 560 men with a first MI and 646 control subjects. The Valencia study included 305 patients with MI at ≤52 years (men and women) and 310 control subjects. In SMILE no clear overall association with the −589C>T genotype was found [odds ratio (OR) 0.84; 95% CI 0.37–1.95 for −589TT and 0.82; 95% CI 0.62–1.07 for −589CT compared with −589CC]. In patients younger than 50 years, carriership of one or two −589T alleles was associated with a reduced risk of MI (OR 0.57: 95% CI 0.34–0.95). This result was replicated in the Valencia study, where carriers of one or two −589T alleles had a reduced risk of MI (OR 0.67: 95% CI 0.47–0.95), with a strong protective effect of the −598T allele in homozygous −589T (OR 0.33: 95% CI 0.10–1.05). In the control subjects of the Valencia study, the −589T allele was associated with reduced levels of F1+2.Conclusion: Our data indicate that the IL-4 haplotype tagged by the −589T allele reduces the risk of MI in young individuals.

AB - Background: Inflammatory reactions contribute to the development of arterial disease. We investigated the role of interleukin-4 (IL-4) in the development of myocardial infarction (MI) by genotyping patients with MI and control subjects for the −589C>T (rs2243250) single nucleotide polymorphism (SNP), which tags a functional haplotype of IL-4.Methods and results: Study of Myocardial Infarctions Leiden (SMILE) included 560 men with a first MI and 646 control subjects. The Valencia study included 305 patients with MI at ≤52 years (men and women) and 310 control subjects. In SMILE no clear overall association with the −589C>T genotype was found [odds ratio (OR) 0.84; 95% CI 0.37–1.95 for −589TT and 0.82; 95% CI 0.62–1.07 for −589CT compared with −589CC]. In patients younger than 50 years, carriership of one or two −589T alleles was associated with a reduced risk of MI (OR 0.57: 95% CI 0.34–0.95). This result was replicated in the Valencia study, where carriers of one or two −589T alleles had a reduced risk of MI (OR 0.67: 95% CI 0.47–0.95), with a strong protective effect of the −598T allele in homozygous −589T (OR 0.33: 95% CI 0.10–1.05). In the control subjects of the Valencia study, the −589T allele was associated with reduced levels of F1+2.Conclusion: Our data indicate that the IL-4 haplotype tagged by the −589T allele reduces the risk of MI in young individuals.

U2 - 10.1111/j.1538-7836.2008.03096.x

DO - 10.1111/j.1538-7836.2008.03096.x

M3 - Article

VL - 6

SP - 1633

EP - 1638

JO - Journal of thrombosis and haemostasis

JF - Journal of thrombosis and haemostasis

SN - 1538-7933

IS - 10

ER -

The −589C>T polymorphism in the interleukin-4 gene (IL-4) is associated with a reduced risk of myocardial infarction in young individuals

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