The clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine

Hendrea Sanne Aletta Tingen*, Gijs D. van Praagh, Pieter H. Nienhuis, Alwin Tubben, Nick D. VAN RIJSEWIJK, Derk Ten Hove, Nouf A. Mushari, T. Samara Martinez-Lucio, Oscar I. Mendoza-Ibañez, Joyce VAN SLUIS, Charalampos Tsoumpas, Andor W.J.M. Glaudemans, Riemer H.J.A. Slart

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

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Abstract

Cardiovascular diseases (CVD) are the leading cause of death worldwide and have an increasing impact on society. Precision medicine, in which optimal care is identified for an individual or a group of individuals rather than for the average population, might provide significant health benefits for this patient group and decrease CVD morbidity and mortality. Molecular imaging provides the opportunity to assess biological processes in individuals in addition to anatomical context provided by other imaging modalities and could prove to be essential in the implementation of precision medicine in CVD. New developments in single-photon emission computed tomography (SPECT) and positron emission tomography (PET) systems, combined with rapid innovations in promising and specific radi-opharmaceuticals, provide an impressive improvement of diagnostic accuracy and therapy evaluation. This may result in improved health outcomes in CVD patients, thereby reducing societal impact. Furthermore, recent technical advances have led to new possibilities for accurate image quantification, dynamic imaging, and quantification of radiotracer kinetics. This potentially allows for better evaluation of disease activity over time and treatment response monitoring. However, the clinical implementation of these new methods has been slow. This review describes the recent advances in molecular imaging and the clinical value of quantitative PET and SPECT in various fields in cardiovascular molecular imaging, such as atherosclerosis, myocardial perfusion and ischemia, infiltrative cardiomyopa-thies, systemic vascular diseases, and infectious cardiovascular diseases. Moreover, the challenges that need to be overcome to achieve clinical translation are addressed, and future directions are provided.

Original languageEnglish
Article number20230704
JournalBritish journal of radiology
Volume96
Issue number1152
DOIs
Publication statusPublished - 1 Nov 2023

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