The colon and terminal ileum in patients with ankylosing spondylitis and controls in Bangladesh: A macroscopic and microscopic study

Nira Ferdous, Nazrul Islam (Corresponding Author), Shamsuddin Mohammed Ishaque, Shabnam Akhter, Mohammad Kamal, Johannes J. Rasker

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Abstract

Objective: Little is known about gut lesions in AS patients in a developing country, such as Bangladesh.
Methods: Full colonoscopy, including the terminal ileum, was performed in 60 AS patients and 20 controls, without diarrhoea, to study macroscopic and microscopic lesions.
Results: In the colon, in 60 AS patients 17 macroscopic lesions were found, of which 11 were in the rectum; only one lesion was found in 20 controls. The prevalence of microscopic lesions in the ascending colon, sigmoid colon and rectum was 51, 44 and 50 in patients, respectively, and 13, 9 and 8 in controls. In the terminal ileum, macroscopic and microscopic lesions were seen in 21/56 and 43/56 AS patients, respectively, and in 1/20 and 9/20 controls. In the AS group, macroscopic (38.5 vs 5%, P < 0.01) and microscopic (76.8 vs 45%, P = 0.009) lesions were more frequent than in controls; no IBD was diagnosed. Findings were comparable in the axial AS group (n = 25) and the mainly peripheral group (n = 35). In AS patients, marked eosinophilic infiltration was observed in the ascending colon and sigmoid colon but not in the rectum, and this infiltration was more than in controls. The colonic mucosa in controls was otherwise comparable with western studies. Anaemia was seen in 18/60 cases. No association was found between anaemia or HLA-B27 status and gut lesions.
Conclusion: There was an equal percentage of microscopic lesions in the whole gut in AS cases and healthy controls. Previous helminth invasions might have played a role. Lesions differ significantly between AS and controls only in the ileum; therefore, the ileal lesions might be more disease related than the colonic ones.
Original languageEnglish
Article numberrky016
JournalRheumatology advances in practice
Volume2
Issue number2
DOIs
Publication statusPublished - 1 Jul 2018

Keywords

  • Microscopic
  • Macroscopic
  • Colonoscopy
  • Large gut
  • Terminal ileum
  • Ankylosing spondylitis
  • Healthy controls

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