The development of a point of care creatinine measurement using disposable ready to use microchip capillary electrophoresis

Mónica Ávila Muñoz; Jan C.T. Eijkel; J. Floris; S.S. Staal; Ángel Ríos; Albert van den Berg

The development of a point of care creatinine measurement using disposable ready to use microchip capillary electrophoresis

Mónica Ávila Muñoz, Jan C.T. Eijkel, J. Floris, S.S. Staal, Ángel Ríos, Albert van den Berg

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

We report on the determination of creatinine in human serum using a point-of-care device suitable for the use by untrained operators, the Medimate Multireader®. This device is based on electrophoretic separation and conductivity detection and its prefilled microfluidic chip has a single opening for sample introduction. The device was originally developed for the determination of lithium in blood [1]. Creatinine determination at a level of quantification of 300 μM was realized by optimizing the background electrolyte (BGE) pH and concentration, and the injection and separation potentials and time. This limit of quantification is in the relevant range for the detection of renal failure [2].

Original language	Undefined
Title of host publication	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Place of Publication	Washington
Publisher	The Chemical and Biological Microsystems Society
Pages	1206-1208
Number of pages	3
ISBN (Print)	978-0-979-8064-4-5
Publication status	Published - 2 Oct 2011
Event	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2011 - Seattle, United States Duration: 2 Oct 2011 → 6 Oct 2011 Conference number: 15 https://microtasconferences.org/microtas2011/

Publication series

Name
Publisher	Chemical and Biological Microsystems Society
ISSN (Print)	1556-5904

Conference

Conference	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2011
Abbreviated title	MicroTAS
Country/Territory	United States
City	Seattle
Period	2/10/11 → 6/10/11
Internet address	https://microtasconferences.org/microtas2011/

Keywords

EWI-20895
creatinine
Point-of-care device
Microchip CE
IR-78660
METIS-281595

Access to Document

http://eprints.eemcs.utwente.nl/secure2/20895/01/404_0398.pdf

Cite this

Ávila Muñoz, M., Eijkel, J. C. T., Floris, J., Staal, S. S., Ríos, Á., & van den Berg, A. (2011). The development of a point of care creatinine measurement using disposable ready to use microchip capillary electrophoresis. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1206-1208). The Chemical and Biological Microsystems Society. http://eprints.eemcs.utwente.nl/secure2/20895/01/404_0398.pdf

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title = "The development of a point of care creatinine measurement using disposable ready to use microchip capillary electrophoresis",

abstract = "We report on the determination of creatinine in human serum using a point-of-care device suitable for the use by untrained operators, the Medimate Multireader{\textregistered}. This device is based on electrophoretic separation and conductivity detection and its prefilled microfluidic chip has a single opening for sample introduction. The device was originally developed for the determination of lithium in blood [1]. Creatinine determination at a level of quantification of 300 μM was realized by optimizing the background electrolyte (BGE) pH and concentration, and the injection and separation potentials and time. This limit of quantification is in the relevant range for the detection of renal failure [2].",

keywords = "EWI-20895, creatinine, Point-of-care device, Microchip CE, IR-78660, METIS-281595",

author = "{{\'A}vila Mu{\~n}oz}, M{\'o}nica and Eijkel, {Jan C.T.} and J. Floris and S.S. Staal and {\'A}ngel R{\'i}os and {van den Berg}, Albert",

year = "2011",

month = oct,

day = "2",

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isbn = "978-0-979-8064-4-5",

publisher = "The Chemical and Biological Microsystems Society",

pages = "1206--1208",

booktitle = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

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Ávila Muñoz, M, Eijkel, JCT, Floris, J, Staal, SS, Ríos, Á & van den Berg, A 2011, The development of a point of care creatinine measurement using disposable ready to use microchip capillary electrophoresis. in 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences. The Chemical and Biological Microsystems Society, Washington, pp. 1206-1208, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2011, Seattle, Washington, United States, 2/10/11. <http://eprints.eemcs.utwente.nl/secure2/20895/01/404_0398.pdf>

The development of a point of care creatinine measurement using disposable ready to use microchip capillary electrophoresis. / Ávila Muñoz, Mónica; Eijkel, Jan C.T.; Floris, J. et al.
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Washington: The Chemical and Biological Microsystems Society, 2011. p. 1206-1208.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - The development of a point of care creatinine measurement using disposable ready to use microchip capillary electrophoresis

AU - Ávila Muñoz, Mónica

AU - Eijkel, Jan C.T.

AU - Floris, J.

AU - Staal, S.S.

AU - Ríos, Ángel

AU - van den Berg, Albert

N1 - Conference code: 15

PY - 2011/10/2

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N2 - We report on the determination of creatinine in human serum using a point-of-care device suitable for the use by untrained operators, the Medimate Multireader®. This device is based on electrophoretic separation and conductivity detection and its prefilled microfluidic chip has a single opening for sample introduction. The device was originally developed for the determination of lithium in blood [1]. Creatinine determination at a level of quantification of 300 μM was realized by optimizing the background electrolyte (BGE) pH and concentration, and the injection and separation potentials and time. This limit of quantification is in the relevant range for the detection of renal failure [2].

AB - We report on the determination of creatinine in human serum using a point-of-care device suitable for the use by untrained operators, the Medimate Multireader®. This device is based on electrophoretic separation and conductivity detection and its prefilled microfluidic chip has a single opening for sample introduction. The device was originally developed for the determination of lithium in blood [1]. Creatinine determination at a level of quantification of 300 μM was realized by optimizing the background electrolyte (BGE) pH and concentration, and the injection and separation potentials and time. This limit of quantification is in the relevant range for the detection of renal failure [2].

KW - EWI-20895

KW - creatinine

KW - Point-of-care device

KW - Microchip CE

KW - IR-78660

KW - METIS-281595

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BT - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - The Chemical and Biological Microsystems Society

CY - Washington

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Ávila Muñoz M, Eijkel JCT, Floris J, Staal SS, Ríos Á, van den Berg A. The development of a point of care creatinine measurement using disposable ready to use microchip capillary electrophoresis. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Washington: The Chemical and Biological Microsystems Society. 2011. p. 1206-1208