The development of a point of care creatinine measurement using disposable ready to use microchip capillary electrophoresis

Mónica Ávila Muñoz, Jan C.T. Eijkel, J. Floris, S.S. Staal, Ángel Ríos, Albert van den Berg

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

    3 Citations (Scopus)

    Abstract

    We report on the determination of creatinine in human serum using a point-of-care device suitable for the use by untrained operators, the Medimate Multireader®. This device is based on electrophoretic separation and conductivity detection and its prefilled microfluidic chip has a single opening for sample introduction. The device was originally developed for the determination of lithium in blood [1]. Creatinine determination at a level of quantification of 300 μM was realized by optimizing the background electrolyte (BGE) pH and concentration, and the injection and separation potentials and time. This limit of quantification is in the relevant range for the detection of renal failure [2].
    Original languageUndefined
    Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    Place of PublicationWashington
    PublisherChemical and Biological Micro Systems Society
    Pages1206-1208
    Number of pages3
    ISBN (Print)978-0-979-8064-4-5
    Publication statusPublished - 2 Oct 2011
    Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2011 - Seattle, United States
    Duration: 2 Oct 20116 Oct 2011
    Conference number: 15
    https://microtasconferences.org/microtas2011/

    Publication series

    Name
    PublisherChemical and Biological Microsystems Society
    ISSN (Print)1556-5904

    Conference

    Conference15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2011
    Abbreviated titleMicroTAS
    CountryUnited States
    CitySeattle
    Period2/10/116/10/11
    Internet address

    Keywords

    • EWI-20895
    • creatinine
    • Point-of-care device
    • Microchip CE
    • IR-78660
    • METIS-281595

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