The diagnostic value of 18F–FDG-PET/CT and MRI in suspected vertebral osteomyelitis – a prospective study

Ilse J.E. Kouijzer (Corresponding Author), Henk Scheper, Jacky W.J. de Rooy, Johan L. Bloem, Marcel J.R. Janssen, Leon van Den Hoven, Allard J.F. Hosman, Leo G. Visser, Wim J.G. Oyen, Chantal P. Bleeker-Rovers, Lioe Fee de Geus-Oei

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Abstract

Purpose: The aim of this study was to determine the diagnostic value of 18F–fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT) and magnetic resonance imaging (MRI) in diagnosing vertebral osteomyelitis. Methods: From November 2015 until December 2016, 32 patients with suspected vertebral osteomyelitis were prospectively included. All patients underwent both 18F–FDG-PET/CT and MRI within 48 h. All images were independently reevaluated by two radiologists and two nuclear medicine physicians who were blinded to each others’ image interpretation. 18F–FDG-PET/CT and MRI were compared to the clinical diagnosis according to international guidelines. Results: For 18F–FDG-PET/CT, sensitivity, specificity, PPV, and NPV in diagnosing vertebral osteomyelitis were 100%, 83.3%, 90.9%, and 100%, respectively. For MRI, sensitivity, specificity, PPV, and NPV were 100%, 91.7%, 95.2%, and 100%, respectively. MRI detected more epidural/spinal abscesses. An important advantage of 18F–FDG-PET/CT is the detection of metastatic infection (16 patients, 50.0%). Conclusion: 18F–FDG-PET/CT and MRI are both necessary techniques in diagnosing vertebral osteomyelitis. An important advantage of 18F–FDG-PET/CT is the visualization of metastatic infection, especially in patients with bacteremia. MRI is more sensitive in detection of small epidural abscesses.

Original languageEnglish
Pages (from-to)798-805
Number of pages8
JournalEuropean journal of nuclear medicine and molecular imaging
Volume45
Issue number5
DOIs
Publication statusPublished - May 2018

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Osteomyelitis
Magnetic Resonance Imaging
Prospective Studies
Epidural Abscess
Sensitivity and Specificity
Nuclear Medicine
Bacteremia
Infection
Positron Emission Tomography Computed Tomography
Guidelines
Physicians

Keywords

  • UT-Hybrid-D
  • Abscesses
  • MRI
  • Vertebral osteomyelitis
  • F–Fdg-pet/ct

Cite this

Kouijzer, Ilse J.E. ; Scheper, Henk ; de Rooy, Jacky W.J. ; Bloem, Johan L. ; Janssen, Marcel J.R. ; van Den Hoven, Leon ; Hosman, Allard J.F. ; Visser, Leo G. ; Oyen, Wim J.G. ; Bleeker-Rovers, Chantal P. ; de Geus-Oei, Lioe Fee. / The diagnostic value of 18F–FDG-PET/CT and MRI in suspected vertebral osteomyelitis – a prospective study. In: European journal of nuclear medicine and molecular imaging. 2018 ; Vol. 45, No. 5. pp. 798-805.
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title = "The diagnostic value of 18F–FDG-PET/CT and MRI in suspected vertebral osteomyelitis – a prospective study",
abstract = "Purpose: The aim of this study was to determine the diagnostic value of 18F–fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT) and magnetic resonance imaging (MRI) in diagnosing vertebral osteomyelitis. Methods: From November 2015 until December 2016, 32 patients with suspected vertebral osteomyelitis were prospectively included. All patients underwent both 18F–FDG-PET/CT and MRI within 48 h. All images were independently reevaluated by two radiologists and two nuclear medicine physicians who were blinded to each others’ image interpretation. 18F–FDG-PET/CT and MRI were compared to the clinical diagnosis according to international guidelines. Results: For 18F–FDG-PET/CT, sensitivity, specificity, PPV, and NPV in diagnosing vertebral osteomyelitis were 100{\%}, 83.3{\%}, 90.9{\%}, and 100{\%}, respectively. For MRI, sensitivity, specificity, PPV, and NPV were 100{\%}, 91.7{\%}, 95.2{\%}, and 100{\%}, respectively. MRI detected more epidural/spinal abscesses. An important advantage of 18F–FDG-PET/CT is the detection of metastatic infection (16 patients, 50.0{\%}). Conclusion: 18F–FDG-PET/CT and MRI are both necessary techniques in diagnosing vertebral osteomyelitis. An important advantage of 18F–FDG-PET/CT is the visualization of metastatic infection, especially in patients with bacteremia. MRI is more sensitive in detection of small epidural abscesses.",
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author = "Kouijzer, {Ilse J.E.} and Henk Scheper and {de Rooy}, {Jacky W.J.} and Bloem, {Johan L.} and Janssen, {Marcel J.R.} and {van Den Hoven}, Leon and Hosman, {Allard J.F.} and Visser, {Leo G.} and Oyen, {Wim J.G.} and Bleeker-Rovers, {Chantal P.} and {de Geus-Oei}, {Lioe Fee}",
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Kouijzer, IJE, Scheper, H, de Rooy, JWJ, Bloem, JL, Janssen, MJR, van Den Hoven, L, Hosman, AJF, Visser, LG, Oyen, WJG, Bleeker-Rovers, CP & de Geus-Oei, LF 2018, 'The diagnostic value of 18F–FDG-PET/CT and MRI in suspected vertebral osteomyelitis – a prospective study' European journal of nuclear medicine and molecular imaging, vol. 45, no. 5, pp. 798-805. https://doi.org/10.1007/s00259-017-3912-0

The diagnostic value of 18F–FDG-PET/CT and MRI in suspected vertebral osteomyelitis – a prospective study. / Kouijzer, Ilse J.E. (Corresponding Author); Scheper, Henk; de Rooy, Jacky W.J.; Bloem, Johan L.; Janssen, Marcel J.R.; van Den Hoven, Leon; Hosman, Allard J.F.; Visser, Leo G.; Oyen, Wim J.G.; Bleeker-Rovers, Chantal P.; de Geus-Oei, Lioe Fee.

In: European journal of nuclear medicine and molecular imaging, Vol. 45, No. 5, 05.2018, p. 798-805.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - The diagnostic value of 18F–FDG-PET/CT and MRI in suspected vertebral osteomyelitis – a prospective study

AU - Kouijzer, Ilse J.E.

AU - Scheper, Henk

AU - de Rooy, Jacky W.J.

AU - Bloem, Johan L.

AU - Janssen, Marcel J.R.

AU - van Den Hoven, Leon

AU - Hosman, Allard J.F.

AU - Visser, Leo G.

AU - Oyen, Wim J.G.

AU - Bleeker-Rovers, Chantal P.

AU - de Geus-Oei, Lioe Fee

N1 - Springer deal

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N2 - Purpose: The aim of this study was to determine the diagnostic value of 18F–fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT) and magnetic resonance imaging (MRI) in diagnosing vertebral osteomyelitis. Methods: From November 2015 until December 2016, 32 patients with suspected vertebral osteomyelitis were prospectively included. All patients underwent both 18F–FDG-PET/CT and MRI within 48 h. All images were independently reevaluated by two radiologists and two nuclear medicine physicians who were blinded to each others’ image interpretation. 18F–FDG-PET/CT and MRI were compared to the clinical diagnosis according to international guidelines. Results: For 18F–FDG-PET/CT, sensitivity, specificity, PPV, and NPV in diagnosing vertebral osteomyelitis were 100%, 83.3%, 90.9%, and 100%, respectively. For MRI, sensitivity, specificity, PPV, and NPV were 100%, 91.7%, 95.2%, and 100%, respectively. MRI detected more epidural/spinal abscesses. An important advantage of 18F–FDG-PET/CT is the detection of metastatic infection (16 patients, 50.0%). Conclusion: 18F–FDG-PET/CT and MRI are both necessary techniques in diagnosing vertebral osteomyelitis. An important advantage of 18F–FDG-PET/CT is the visualization of metastatic infection, especially in patients with bacteremia. MRI is more sensitive in detection of small epidural abscesses.

AB - Purpose: The aim of this study was to determine the diagnostic value of 18F–fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT) and magnetic resonance imaging (MRI) in diagnosing vertebral osteomyelitis. Methods: From November 2015 until December 2016, 32 patients with suspected vertebral osteomyelitis were prospectively included. All patients underwent both 18F–FDG-PET/CT and MRI within 48 h. All images were independently reevaluated by two radiologists and two nuclear medicine physicians who were blinded to each others’ image interpretation. 18F–FDG-PET/CT and MRI were compared to the clinical diagnosis according to international guidelines. Results: For 18F–FDG-PET/CT, sensitivity, specificity, PPV, and NPV in diagnosing vertebral osteomyelitis were 100%, 83.3%, 90.9%, and 100%, respectively. For MRI, sensitivity, specificity, PPV, and NPV were 100%, 91.7%, 95.2%, and 100%, respectively. MRI detected more epidural/spinal abscesses. An important advantage of 18F–FDG-PET/CT is the detection of metastatic infection (16 patients, 50.0%). Conclusion: 18F–FDG-PET/CT and MRI are both necessary techniques in diagnosing vertebral osteomyelitis. An important advantage of 18F–FDG-PET/CT is the visualization of metastatic infection, especially in patients with bacteremia. MRI is more sensitive in detection of small epidural abscesses.

KW - UT-Hybrid-D

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JF - European journal of nuclear medicine and molecular imaging

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