The diagnostic value of 18F–FDG-PET/CT and MRI in suspected vertebral osteomyelitis – a prospective study

Ilse J.E. Kouijzer* (Corresponding Author), Henk Scheper, Jacky W.J. de Rooy, Johan L. Bloem, Marcel J.R. Janssen, Leon van Den Hoven, Allard J.F. Hosman, Leo G. Visser, Wim J.G. Oyen, Chantal P. Bleeker-Rovers, Lioe Fee de Geus-Oei

*Corresponding author for this work

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Abstract

Purpose: The aim of this study was to determine the diagnostic value of 18F–fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT) and magnetic resonance imaging (MRI) in diagnosing vertebral osteomyelitis. Methods: From November 2015 until December 2016, 32 patients with suspected vertebral osteomyelitis were prospectively included. All patients underwent both 18F–FDG-PET/CT and MRI within 48 h. All images were independently reevaluated by two radiologists and two nuclear medicine physicians who were blinded to each others’ image interpretation. 18F–FDG-PET/CT and MRI were compared to the clinical diagnosis according to international guidelines. Results: For 18F–FDG-PET/CT, sensitivity, specificity, PPV, and NPV in diagnosing vertebral osteomyelitis were 100%, 83.3%, 90.9%, and 100%, respectively. For MRI, sensitivity, specificity, PPV, and NPV were 100%, 91.7%, 95.2%, and 100%, respectively. MRI detected more epidural/spinal abscesses. An important advantage of 18F–FDG-PET/CT is the detection of metastatic infection (16 patients, 50.0%). Conclusion: 18F–FDG-PET/CT and MRI are both necessary techniques in diagnosing vertebral osteomyelitis. An important advantage of 18F–FDG-PET/CT is the visualization of metastatic infection, especially in patients with bacteremia. MRI is more sensitive in detection of small epidural abscesses.

Original languageEnglish
Pages (from-to)798-805
Number of pages8
JournalEuropean journal of nuclear medicine and molecular imaging
Volume45
Issue number5
DOIs
Publication statusPublished - May 2018

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Osteomyelitis
Magnetic Resonance Imaging
Prospective Studies
Epidural Abscess
Sensitivity and Specificity
Nuclear Medicine
Bacteremia
Infection
Positron Emission Tomography Computed Tomography
Guidelines
Physicians

Keywords

  • UT-Hybrid-D
  • Abscesses
  • MRI
  • Vertebral osteomyelitis
  • F–Fdg-pet/ct

Cite this

Kouijzer, Ilse J.E. ; Scheper, Henk ; de Rooy, Jacky W.J. ; Bloem, Johan L. ; Janssen, Marcel J.R. ; van Den Hoven, Leon ; Hosman, Allard J.F. ; Visser, Leo G. ; Oyen, Wim J.G. ; Bleeker-Rovers, Chantal P. ; de Geus-Oei, Lioe Fee. / The diagnostic value of 18F–FDG-PET/CT and MRI in suspected vertebral osteomyelitis – a prospective study. In: European journal of nuclear medicine and molecular imaging. 2018 ; Vol. 45, No. 5. pp. 798-805.
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title = "The diagnostic value of 18F–FDG-PET/CT and MRI in suspected vertebral osteomyelitis – a prospective study",
abstract = "Purpose: The aim of this study was to determine the diagnostic value of 18F–fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT) and magnetic resonance imaging (MRI) in diagnosing vertebral osteomyelitis. Methods: From November 2015 until December 2016, 32 patients with suspected vertebral osteomyelitis were prospectively included. All patients underwent both 18F–FDG-PET/CT and MRI within 48 h. All images were independently reevaluated by two radiologists and two nuclear medicine physicians who were blinded to each others’ image interpretation. 18F–FDG-PET/CT and MRI were compared to the clinical diagnosis according to international guidelines. Results: For 18F–FDG-PET/CT, sensitivity, specificity, PPV, and NPV in diagnosing vertebral osteomyelitis were 100{\%}, 83.3{\%}, 90.9{\%}, and 100{\%}, respectively. For MRI, sensitivity, specificity, PPV, and NPV were 100{\%}, 91.7{\%}, 95.2{\%}, and 100{\%}, respectively. MRI detected more epidural/spinal abscesses. An important advantage of 18F–FDG-PET/CT is the detection of metastatic infection (16 patients, 50.0{\%}). Conclusion: 18F–FDG-PET/CT and MRI are both necessary techniques in diagnosing vertebral osteomyelitis. An important advantage of 18F–FDG-PET/CT is the visualization of metastatic infection, especially in patients with bacteremia. MRI is more sensitive in detection of small epidural abscesses.",
keywords = "UT-Hybrid-D, Abscesses, MRI, Vertebral osteomyelitis, F–Fdg-pet/ct",
author = "Kouijzer, {Ilse J.E.} and Henk Scheper and {de Rooy}, {Jacky W.J.} and Bloem, {Johan L.} and Janssen, {Marcel J.R.} and {van Den Hoven}, Leon and Hosman, {Allard J.F.} and Visser, {Leo G.} and Oyen, {Wim J.G.} and Bleeker-Rovers, {Chantal P.} and {de Geus-Oei}, {Lioe Fee}",
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Kouijzer, IJE, Scheper, H, de Rooy, JWJ, Bloem, JL, Janssen, MJR, van Den Hoven, L, Hosman, AJF, Visser, LG, Oyen, WJG, Bleeker-Rovers, CP & de Geus-Oei, LF 2018, 'The diagnostic value of 18F–FDG-PET/CT and MRI in suspected vertebral osteomyelitis – a prospective study', European journal of nuclear medicine and molecular imaging, vol. 45, no. 5, pp. 798-805. https://doi.org/10.1007/s00259-017-3912-0

The diagnostic value of 18F–FDG-PET/CT and MRI in suspected vertebral osteomyelitis – a prospective study. / Kouijzer, Ilse J.E. (Corresponding Author); Scheper, Henk; de Rooy, Jacky W.J.; Bloem, Johan L.; Janssen, Marcel J.R.; van Den Hoven, Leon; Hosman, Allard J.F.; Visser, Leo G.; Oyen, Wim J.G.; Bleeker-Rovers, Chantal P.; de Geus-Oei, Lioe Fee.

In: European journal of nuclear medicine and molecular imaging, Vol. 45, No. 5, 05.2018, p. 798-805.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - The diagnostic value of 18F–FDG-PET/CT and MRI in suspected vertebral osteomyelitis – a prospective study

AU - Kouijzer, Ilse J.E.

AU - Scheper, Henk

AU - de Rooy, Jacky W.J.

AU - Bloem, Johan L.

AU - Janssen, Marcel J.R.

AU - van Den Hoven, Leon

AU - Hosman, Allard J.F.

AU - Visser, Leo G.

AU - Oyen, Wim J.G.

AU - Bleeker-Rovers, Chantal P.

AU - de Geus-Oei, Lioe Fee

N1 - Springer deal

PY - 2018/5

Y1 - 2018/5

N2 - Purpose: The aim of this study was to determine the diagnostic value of 18F–fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT) and magnetic resonance imaging (MRI) in diagnosing vertebral osteomyelitis. Methods: From November 2015 until December 2016, 32 patients with suspected vertebral osteomyelitis were prospectively included. All patients underwent both 18F–FDG-PET/CT and MRI within 48 h. All images were independently reevaluated by two radiologists and two nuclear medicine physicians who were blinded to each others’ image interpretation. 18F–FDG-PET/CT and MRI were compared to the clinical diagnosis according to international guidelines. Results: For 18F–FDG-PET/CT, sensitivity, specificity, PPV, and NPV in diagnosing vertebral osteomyelitis were 100%, 83.3%, 90.9%, and 100%, respectively. For MRI, sensitivity, specificity, PPV, and NPV were 100%, 91.7%, 95.2%, and 100%, respectively. MRI detected more epidural/spinal abscesses. An important advantage of 18F–FDG-PET/CT is the detection of metastatic infection (16 patients, 50.0%). Conclusion: 18F–FDG-PET/CT and MRI are both necessary techniques in diagnosing vertebral osteomyelitis. An important advantage of 18F–FDG-PET/CT is the visualization of metastatic infection, especially in patients with bacteremia. MRI is more sensitive in detection of small epidural abscesses.

AB - Purpose: The aim of this study was to determine the diagnostic value of 18F–fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT) and magnetic resonance imaging (MRI) in diagnosing vertebral osteomyelitis. Methods: From November 2015 until December 2016, 32 patients with suspected vertebral osteomyelitis were prospectively included. All patients underwent both 18F–FDG-PET/CT and MRI within 48 h. All images were independently reevaluated by two radiologists and two nuclear medicine physicians who were blinded to each others’ image interpretation. 18F–FDG-PET/CT and MRI were compared to the clinical diagnosis according to international guidelines. Results: For 18F–FDG-PET/CT, sensitivity, specificity, PPV, and NPV in diagnosing vertebral osteomyelitis were 100%, 83.3%, 90.9%, and 100%, respectively. For MRI, sensitivity, specificity, PPV, and NPV were 100%, 91.7%, 95.2%, and 100%, respectively. MRI detected more epidural/spinal abscesses. An important advantage of 18F–FDG-PET/CT is the detection of metastatic infection (16 patients, 50.0%). Conclusion: 18F–FDG-PET/CT and MRI are both necessary techniques in diagnosing vertebral osteomyelitis. An important advantage of 18F–FDG-PET/CT is the visualization of metastatic infection, especially in patients with bacteremia. MRI is more sensitive in detection of small epidural abscesses.

KW - UT-Hybrid-D

KW - Abscesses

KW - MRI

KW - Vertebral osteomyelitis

KW - F–Fdg-pet/ct

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JO - European journal of nuclear medicine and molecular imaging

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SN - 1619-7070

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