The effect of metabolic alkalosis on the ventilatory response in healthy subjects

E. Oppersma, J. Doorduin, J.G. van der Hoeven, P.H. Veltink, H.W.H. van Hees, L.M.A. Heunks* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)
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Background: Patients with acute respiratory failure may develop respiratory acidosis. Metabolic compensation by bicarbonate production or retention results in posthypercapnic alkalosis with an increased arterial bicarbonate concentration. The hypothesis of this study was that elevated plasma bicarbonate levels decrease respiratory drive and minute ventilation.

Methods: In an intervention study in 10 healthy subjects the ventilatory response using a hypercapnic ventilatory response (HCVR) test was assessed, before and after administration of high dose sodium bicarbonate. Total dose of sodiumbicarbonate was 1000 ml 8.4% in 3 days.

Results: Plasma bicarbonate increased from 25.2 ± 2.2 to 29.2 ± 1.9 mmol/L. With increasing inspiratory CO2 pressure during the HCVR test, RR, Vt, Pdi, EAdi and VE increased. The clinical ratio ΔVE/ΔPetCO2 remained unchanged, but Pdi, EAdi and VE were significantly lower after bicarbonate administration for similar levels of inspired CO2.

Conclusion: This study demonstrates that in healthy subjects metabolic alkalosis decreases the neural respiratory drive and minute ventilation, as a response to inspiratory CO2.
Original languageEnglish
Pages (from-to)47-53
Number of pages7
JournalRespiratory Physiology and Neurobiology
Publication statusPublished - Feb 2018


  • UT-Hybrid-D
  • Neural respiratory drive
  • Posthypercapnic alkalosis
  • Pulnonary function test
  • Physiology


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