The Effect of Minimally Invasive Surfactant Therapy on Diaphragmatic Activity

Cornelia G. De Waal; Gerard J. Hutten; Frans H. De Jongh; Anton H. Van Kaam

doi:10.1159/000487916

The Effect of Minimally Invasive Surfactant Therapy on Diaphragmatic Activity

Cornelia G. De Waal^*, Gerard J. Hutten, Frans H. De Jongh, Anton H. Van Kaam

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

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Abstract

Background: Minimally invasive surfactant therapy (MIST) is increasingly used to treat preterm infants with respiratory distress syndrome (RDS). However, the effect of MIST on breathing effort is poorly studied. Objectives: To describe the effect of MIST on neural breathing effort assessed with transcutaneous electromyography of the diaphragm (dEMG) in preterm infants with RDS. Methods: Preterm infants with a gestational age < 37 weeks treated with MIST for RDS were included. dEMG measurements were done from 15 min before to 1 h after MIST. The percentage change in dEMG activity after MIST and the clinical response were analyzed. Results: Twenty preterm infants (mean gestational age 29.3 [SD 2.1] weeks; mean birth weight 1,230 [SD 391] g) were included. Seventeen infants did complete the 1-h measurement. Eleven (65%) infants had a decrease in their peak_dEMG activity (median change -11.8% [IQR -26.8 to 5.8, p = 0.08]) 1 h after MIST. Tonic_dEMG activity decreased in 12 (71%) infants, with a median reduction of 6.3% (IQR -29.2 to 9.0, p = 0.07). FiO₂ showed a rapid decrease following MIST (before, 0.47 [IQR 0.38-0.84]; 1 h after, 0.25 [IQR 0.21-0.30], p < 0.001). Conclusion: In addition to improved oxygenation, MIST results in a decrease in neural breathing effort measured by dEMG activity in the majority of preterm infants with RDS.

Original language	English
Pages (from-to)	76-81
Number of pages	6
Journal	Neonatology
Volume	114
Issue number	1
DOIs	https://doi.org/10.1159/000487916
Publication status	Published - 1 Jun 2018
Externally published	Yes

Keywords

Electromyography of the diaphragm
Preterm infants
Respiratory distress syndrome
Surfactant

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000487916Licence: CC BY-NC-ND

effectFinal published version, 656 KBLicence: CC BY-NC-ND

Cite this

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title = "The Effect of Minimally Invasive Surfactant Therapy on Diaphragmatic Activity",

abstract = "Background: Minimally invasive surfactant therapy (MIST) is increasingly used to treat preterm infants with respiratory distress syndrome (RDS). However, the effect of MIST on breathing effort is poorly studied. Objectives: To describe the effect of MIST on neural breathing effort assessed with transcutaneous electromyography of the diaphragm (dEMG) in preterm infants with RDS. Methods: Preterm infants with a gestational age < 37 weeks treated with MIST for RDS were included. dEMG measurements were done from 15 min before to 1 h after MIST. The percentage change in dEMG activity after MIST and the clinical response were analyzed. Results: Twenty preterm infants (mean gestational age 29.3 [SD 2.1] weeks; mean birth weight 1,230 [SD 391] g) were included. Seventeen infants did complete the 1-h measurement. Eleven (65\%) infants had a decrease in their peakdEMG activity (median change -11.8\% [IQR -26.8 to 5.8, p = 0.08]) 1 h after MIST. TonicdEMG activity decreased in 12 (71\%) infants, with a median reduction of 6.3\% (IQR -29.2 to 9.0, p = 0.07). FiO2 showed a rapid decrease following MIST (before, 0.47 [IQR 0.38-0.84]; 1 h after, 0.25 [IQR 0.21-0.30], p < 0.001). Conclusion: In addition to improved oxygenation, MIST results in a decrease in neural breathing effort measured by dEMG activity in the majority of preterm infants with RDS.",

keywords = "Electromyography of the diaphragm, Preterm infants, Respiratory distress syndrome, Surfactant",

author = "\{De Waal\}, \{Cornelia G.\} and Hutten, \{Gerard J.\} and \{De Jongh\}, \{Frans H.\} and \{Van Kaam\}, \{Anton H.\}",

year = "2018",

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doi = "10.1159/000487916",

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pages = "76--81",

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T1 - The Effect of Minimally Invasive Surfactant Therapy on Diaphragmatic Activity

AU - De Waal, Cornelia G.

AU - Hutten, Gerard J.

AU - De Jongh, Frans H.

AU - Van Kaam, Anton H.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Background: Minimally invasive surfactant therapy (MIST) is increasingly used to treat preterm infants with respiratory distress syndrome (RDS). However, the effect of MIST on breathing effort is poorly studied. Objectives: To describe the effect of MIST on neural breathing effort assessed with transcutaneous electromyography of the diaphragm (dEMG) in preterm infants with RDS. Methods: Preterm infants with a gestational age < 37 weeks treated with MIST for RDS were included. dEMG measurements were done from 15 min before to 1 h after MIST. The percentage change in dEMG activity after MIST and the clinical response were analyzed. Results: Twenty preterm infants (mean gestational age 29.3 [SD 2.1] weeks; mean birth weight 1,230 [SD 391] g) were included. Seventeen infants did complete the 1-h measurement. Eleven (65%) infants had a decrease in their peakdEMG activity (median change -11.8% [IQR -26.8 to 5.8, p = 0.08]) 1 h after MIST. TonicdEMG activity decreased in 12 (71%) infants, with a median reduction of 6.3% (IQR -29.2 to 9.0, p = 0.07). FiO2 showed a rapid decrease following MIST (before, 0.47 [IQR 0.38-0.84]; 1 h after, 0.25 [IQR 0.21-0.30], p < 0.001). Conclusion: In addition to improved oxygenation, MIST results in a decrease in neural breathing effort measured by dEMG activity in the majority of preterm infants with RDS.

AB - Background: Minimally invasive surfactant therapy (MIST) is increasingly used to treat preterm infants with respiratory distress syndrome (RDS). However, the effect of MIST on breathing effort is poorly studied. Objectives: To describe the effect of MIST on neural breathing effort assessed with transcutaneous electromyography of the diaphragm (dEMG) in preterm infants with RDS. Methods: Preterm infants with a gestational age < 37 weeks treated with MIST for RDS were included. dEMG measurements were done from 15 min before to 1 h after MIST. The percentage change in dEMG activity after MIST and the clinical response were analyzed. Results: Twenty preterm infants (mean gestational age 29.3 [SD 2.1] weeks; mean birth weight 1,230 [SD 391] g) were included. Seventeen infants did complete the 1-h measurement. Eleven (65%) infants had a decrease in their peakdEMG activity (median change -11.8% [IQR -26.8 to 5.8, p = 0.08]) 1 h after MIST. TonicdEMG activity decreased in 12 (71%) infants, with a median reduction of 6.3% (IQR -29.2 to 9.0, p = 0.07). FiO2 showed a rapid decrease following MIST (before, 0.47 [IQR 0.38-0.84]; 1 h after, 0.25 [IQR 0.21-0.30], p < 0.001). Conclusion: In addition to improved oxygenation, MIST results in a decrease in neural breathing effort measured by dEMG activity in the majority of preterm infants with RDS.

KW - Electromyography of the diaphragm

KW - Preterm infants

KW - Respiratory distress syndrome

KW - Surfactant

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DO - 10.1159/000487916

M3 - Article

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SN - 1661-7800

VL - 114

SP - 76

EP - 81

JO - Neonatology

JF - Neonatology

IS - 1

ER -

The Effect of Minimally Invasive Surfactant Therapy on Diaphragmatic Activity

Abstract

Keywords

UN SDGs

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