The effects of probe placement on measured flow velocity in transcranial Doppler ultrasound imaging in-vitro and in-vivo experiments

Daan L.K. de Jong, Aisha van den Abeelen, Joep Lagro, Jurgen A.H.R. Claassen, Cornelis H. Slump

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

The measurement of the blood flow in the middle cerebral artery (MCA) using transcranial Doppler ultrasound (US) imaging is clinically relevant for the study of cerebral autoregulation. Especially in the aging population, impairement of the autoregulation may coincide or relate to loss of perfusion and consequently loss of brain function. The cerebral autoregulation can be assessed by relating the blood pressure to the blood flow in the brain. Doppler US is a widely used, non-invasive method to measure the blood flow in the MCA. However, Doppler flow imaging is known to produce results that are dependent of the operator. The angle of the probe insonation with respect to the centerline of the blood vessel is a well known factor for output variability. In patients also the skull must be traversed and the MCA must be detected, influencing the US signal intensity. In this contribution we report two studies. We describe first an in-vitro setup to study the Doppler flow in a situation where the ground truth is known. Secondly, we report on a study with healthy volunteers where the effects of small probe displacements on the flow velocity signals are investigated. For the latter purpose, a special probe holder was designed to control the experiment.
Original languageUndefined
Title of host publicationMedical Imaging 2014: Ultrasonic Imaging and Tomography
EditorsJ.G. Bosch, M.M. Doyley
Place of PublicationBellingham, Washington
PublisherSPIE
Pages904020-1-904020-7
Number of pages7
ISBN (Print)978-0-8194-9835-9
DOIs
Publication statusPublished - 15 Feb 2014

Publication series

NameProceedings of SPIE
PublisherSPIE
Number9040
Volume9040
ISSN (Print)0277-786X

Keywords

  • EWI-25331
  • flow set-up
  • transcranial Doppler
  • phantom design
  • METIS-309673
  • Cerebral blood flow velocity
  • IR-93015
  • In vitro
  • In vivo
  • Quantitative imaging

Cite this

de Jong, D. L. K., van den Abeelen, A., Lagro, J., Claassen, J. A. H. R., & Slump, C. H. (2014). The effects of probe placement on measured flow velocity in transcranial Doppler ultrasound imaging in-vitro and in-vivo experiments. In J. G. Bosch, & M. M. Doyley (Eds.), Medical Imaging 2014: Ultrasonic Imaging and Tomography (pp. 904020-1-904020-7). (Proceedings of SPIE; Vol. 9040, No. 9040). Bellingham, Washington: SPIE. https://doi.org/10.1117/12.2042329
de Jong, Daan L.K. ; van den Abeelen, Aisha ; Lagro, Joep ; Claassen, Jurgen A.H.R. ; Slump, Cornelis H. / The effects of probe placement on measured flow velocity in transcranial Doppler ultrasound imaging in-vitro and in-vivo experiments. Medical Imaging 2014: Ultrasonic Imaging and Tomography. editor / J.G. Bosch ; M.M. Doyley. Bellingham, Washington : SPIE, 2014. pp. 904020-1-904020-7 (Proceedings of SPIE; 9040).
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title = "The effects of probe placement on measured flow velocity in transcranial Doppler ultrasound imaging in-vitro and in-vivo experiments",
abstract = "The measurement of the blood flow in the middle cerebral artery (MCA) using transcranial Doppler ultrasound (US) imaging is clinically relevant for the study of cerebral autoregulation. Especially in the aging population, impairement of the autoregulation may coincide or relate to loss of perfusion and consequently loss of brain function. The cerebral autoregulation can be assessed by relating the blood pressure to the blood flow in the brain. Doppler US is a widely used, non-invasive method to measure the blood flow in the MCA. However, Doppler flow imaging is known to produce results that are dependent of the operator. The angle of the probe insonation with respect to the centerline of the blood vessel is a well known factor for output variability. In patients also the skull must be traversed and the MCA must be detected, influencing the US signal intensity. In this contribution we report two studies. We describe first an in-vitro setup to study the Doppler flow in a situation where the ground truth is known. Secondly, we report on a study with healthy volunteers where the effects of small probe displacements on the flow velocity signals are investigated. For the latter purpose, a special probe holder was designed to control the experiment.",
keywords = "EWI-25331, flow set-up, transcranial Doppler, phantom design, METIS-309673, Cerebral blood flow velocity, IR-93015, In vitro, In vivo, Quantitative imaging",
author = "{de Jong}, {Daan L.K.} and {van den Abeelen}, Aisha and Joep Lagro and Claassen, {Jurgen A.H.R.} and Slump, {Cornelis H.}",
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series = "Proceedings of SPIE",
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de Jong, DLK, van den Abeelen, A, Lagro, J, Claassen, JAHR & Slump, CH 2014, The effects of probe placement on measured flow velocity in transcranial Doppler ultrasound imaging in-vitro and in-vivo experiments. in JG Bosch & MM Doyley (eds), Medical Imaging 2014: Ultrasonic Imaging and Tomography. Proceedings of SPIE, no. 9040, vol. 9040, SPIE, Bellingham, Washington, pp. 904020-1-904020-7. https://doi.org/10.1117/12.2042329

The effects of probe placement on measured flow velocity in transcranial Doppler ultrasound imaging in-vitro and in-vivo experiments. / de Jong, Daan L.K.; van den Abeelen, Aisha; Lagro, Joep; Claassen, Jurgen A.H.R.; Slump, Cornelis H.

Medical Imaging 2014: Ultrasonic Imaging and Tomography. ed. / J.G. Bosch; M.M. Doyley. Bellingham, Washington : SPIE, 2014. p. 904020-1-904020-7 (Proceedings of SPIE; Vol. 9040, No. 9040).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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AU - Claassen, Jurgen A.H.R.

AU - Slump, Cornelis H.

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N2 - The measurement of the blood flow in the middle cerebral artery (MCA) using transcranial Doppler ultrasound (US) imaging is clinically relevant for the study of cerebral autoregulation. Especially in the aging population, impairement of the autoregulation may coincide or relate to loss of perfusion and consequently loss of brain function. The cerebral autoregulation can be assessed by relating the blood pressure to the blood flow in the brain. Doppler US is a widely used, non-invasive method to measure the blood flow in the MCA. However, Doppler flow imaging is known to produce results that are dependent of the operator. The angle of the probe insonation with respect to the centerline of the blood vessel is a well known factor for output variability. In patients also the skull must be traversed and the MCA must be detected, influencing the US signal intensity. In this contribution we report two studies. We describe first an in-vitro setup to study the Doppler flow in a situation where the ground truth is known. Secondly, we report on a study with healthy volunteers where the effects of small probe displacements on the flow velocity signals are investigated. For the latter purpose, a special probe holder was designed to control the experiment.

AB - The measurement of the blood flow in the middle cerebral artery (MCA) using transcranial Doppler ultrasound (US) imaging is clinically relevant for the study of cerebral autoregulation. Especially in the aging population, impairement of the autoregulation may coincide or relate to loss of perfusion and consequently loss of brain function. The cerebral autoregulation can be assessed by relating the blood pressure to the blood flow in the brain. Doppler US is a widely used, non-invasive method to measure the blood flow in the MCA. However, Doppler flow imaging is known to produce results that are dependent of the operator. The angle of the probe insonation with respect to the centerline of the blood vessel is a well known factor for output variability. In patients also the skull must be traversed and the MCA must be detected, influencing the US signal intensity. In this contribution we report two studies. We describe first an in-vitro setup to study the Doppler flow in a situation where the ground truth is known. Secondly, we report on a study with healthy volunteers where the effects of small probe displacements on the flow velocity signals are investigated. For the latter purpose, a special probe holder was designed to control the experiment.

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KW - phantom design

KW - METIS-309673

KW - Cerebral blood flow velocity

KW - IR-93015

KW - In vitro

KW - In vivo

KW - Quantitative imaging

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DO - 10.1117/12.2042329

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SN - 978-0-8194-9835-9

T3 - Proceedings of SPIE

SP - 904020-1-904020-7

BT - Medical Imaging 2014: Ultrasonic Imaging and Tomography

A2 - Bosch, J.G.

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PB - SPIE

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de Jong DLK, van den Abeelen A, Lagro J, Claassen JAHR, Slump CH. The effects of probe placement on measured flow velocity in transcranial Doppler ultrasound imaging in-vitro and in-vivo experiments. In Bosch JG, Doyley MM, editors, Medical Imaging 2014: Ultrasonic Imaging and Tomography. Bellingham, Washington: SPIE. 2014. p. 904020-1-904020-7. (Proceedings of SPIE; 9040). https://doi.org/10.1117/12.2042329