The effects of probe placement on measured flow velocity in transcranial Doppler ultrasound imaging in-vitro and in-vivo experiments

Daan L.K. de Jong; Aisha van den Abeelen; Joep Lagro; Jurgen A.H.R. Claassen; Cornelis H. Slump

doi:10.1117/12.2042329

The effects of probe placement on measured flow velocity in transcranial Doppler ultrasound imaging in-vitro and in-vivo experiments

Daan L.K. de Jong, Aisha van den Abeelen, Joep Lagro, Jurgen A.H.R. Claassen, Cornelis H. Slump

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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Abstract

The measurement of the blood flow in the middle cerebral artery (MCA) using transcranial Doppler ultrasound (US) imaging is clinically relevant for the study of cerebral autoregulation. Especially in the aging population, impairement of the autoregulation may coincide or relate to loss of perfusion and consequently loss of brain function. The cerebral autoregulation can be assessed by relating the blood pressure to the blood flow in the brain. Doppler US is a widely used, non-invasive method to measure the blood flow in the MCA. However, Doppler flow imaging is known to produce results that are dependent of the operator. The angle of the probe insonation with respect to the centerline of the blood vessel is a well known factor for output variability. In patients also the skull must be traversed and the MCA must be detected, influencing the US signal intensity. In this contribution we report two studies. We describe first an in-vitro setup to study the Doppler flow in a situation where the ground truth is known. Secondly, we report on a study with healthy volunteers where the effects of small probe displacements on the flow velocity signals are investigated. For the latter purpose, a special probe holder was designed to control the experiment.

Original language	Undefined
Title of host publication	Medical Imaging 2014: Ultrasonic Imaging and Tomography
Editors	J.G. Bosch, M.M. Doyley
Place of Publication	Bellingham, Washington
Publisher	SPIE
Pages	904020-1-904020-7
Number of pages	7
ISBN (Print)	978-0-8194-9835-9
DOIs	https://doi.org/10.1117/12.2042329
Publication status	Published - 15 Feb 2014
Event	Medical Imaging 2014 - San Diego, United States Duration: 15 Feb 2014 → 20 Feb 2014

Publication series

Name	Proceedings of SPIE
Publisher	SPIE
Number	9040
Volume	9040
ISSN (Print)	0277-786X

Conference

Conference	Medical Imaging 2014
Country/Territory	United States
City	San Diego
Period	15/02/14 → 20/02/14

Keywords

EWI-25331
flow set-up
transcranial Doppler
phantom design
METIS-309673
Cerebral blood flow velocity
IR-93015
In vitro
In vivo
Quantitative imaging

Access to Document

10.1117/12.2042329

http://eprints.eemcs.utwente.nl/secure2/25331/01/SPIE_2014_De_Jong_Slump.pdf

Cite this

de Jong, D. L. K., van den Abeelen, A., Lagro, J., Claassen, J. A. H. R., & Slump, C. H. (2014). The effects of probe placement on measured flow velocity in transcranial Doppler ultrasound imaging in-vitro and in-vivo experiments. In J. G. Bosch, & M. M. Doyley (Eds.), Medical Imaging 2014: Ultrasonic Imaging and Tomography (pp. 904020-1-904020-7). (Proceedings of SPIE; Vol. 9040, No. 9040). SPIE. https://doi.org/10.1117/12.2042329

de Jong, Daan L.K. ; van den Abeelen, Aisha ; Lagro, Joep et al. / The effects of probe placement on measured flow velocity in transcranial Doppler ultrasound imaging in-vitro and in-vivo experiments. Medical Imaging 2014: Ultrasonic Imaging and Tomography. editor / J.G. Bosch ; M.M. Doyley. Bellingham, Washington : SPIE, 2014. pp. 904020-1-904020-7 (Proceedings of SPIE; 9040).

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title = "The effects of probe placement on measured flow velocity in transcranial Doppler ultrasound imaging in-vitro and in-vivo experiments",

abstract = "The measurement of the blood flow in the middle cerebral artery (MCA) using transcranial Doppler ultrasound (US) imaging is clinically relevant for the study of cerebral autoregulation. Especially in the aging population, impairement of the autoregulation may coincide or relate to loss of perfusion and consequently loss of brain function. The cerebral autoregulation can be assessed by relating the blood pressure to the blood flow in the brain. Doppler US is a widely used, non-invasive method to measure the blood flow in the MCA. However, Doppler flow imaging is known to produce results that are dependent of the operator. The angle of the probe insonation with respect to the centerline of the blood vessel is a well known factor for output variability. In patients also the skull must be traversed and the MCA must be detected, influencing the US signal intensity. In this contribution we report two studies. We describe first an in-vitro setup to study the Doppler flow in a situation where the ground truth is known. Secondly, we report on a study with healthy volunteers where the effects of small probe displacements on the flow velocity signals are investigated. For the latter purpose, a special probe holder was designed to control the experiment.",

keywords = "EWI-25331, flow set-up, transcranial Doppler, phantom design, METIS-309673, Cerebral blood flow velocity, IR-93015, In vitro, In vivo, Quantitative imaging",

author = "{de Jong}, {Daan L.K.} and {van den Abeelen}, Aisha and Joep Lagro and Claassen, {Jurgen A.H.R.} and Slump, {Cornelis H.}",

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de Jong, DLK, van den Abeelen, A, Lagro, J, Claassen, JAHR & Slump, CH 2014, The effects of probe placement on measured flow velocity in transcranial Doppler ultrasound imaging in-vitro and in-vivo experiments. in JG Bosch & MM Doyley (eds), Medical Imaging 2014: Ultrasonic Imaging and Tomography. Proceedings of SPIE, no. 9040, vol. 9040, SPIE, Bellingham, Washington, pp. 904020-1-904020-7, Medical Imaging 2014, San Diego, California, United States, 15/02/14. https://doi.org/10.1117/12.2042329

The effects of probe placement on measured flow velocity in transcranial Doppler ultrasound imaging in-vitro and in-vivo experiments. / de Jong, Daan L.K.; van den Abeelen, Aisha; Lagro, Joep et al.
Medical Imaging 2014: Ultrasonic Imaging and Tomography. ed. / J.G. Bosch; M.M. Doyley. Bellingham, Washington: SPIE, 2014. p. 904020-1-904020-7 (Proceedings of SPIE; Vol. 9040, No. 9040).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

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AB - The measurement of the blood flow in the middle cerebral artery (MCA) using transcranial Doppler ultrasound (US) imaging is clinically relevant for the study of cerebral autoregulation. Especially in the aging population, impairement of the autoregulation may coincide or relate to loss of perfusion and consequently loss of brain function. The cerebral autoregulation can be assessed by relating the blood pressure to the blood flow in the brain. Doppler US is a widely used, non-invasive method to measure the blood flow in the MCA. However, Doppler flow imaging is known to produce results that are dependent of the operator. The angle of the probe insonation with respect to the centerline of the blood vessel is a well known factor for output variability. In patients also the skull must be traversed and the MCA must be detected, influencing the US signal intensity. In this contribution we report two studies. We describe first an in-vitro setup to study the Doppler flow in a situation where the ground truth is known. Secondly, we report on a study with healthy volunteers where the effects of small probe displacements on the flow velocity signals are investigated. For the latter purpose, a special probe holder was designed to control the experiment.

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KW - Cerebral blood flow velocity

KW - IR-93015

KW - In vitro

KW - In vivo

KW - Quantitative imaging

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de Jong DLK, van den Abeelen A, Lagro J, Claassen JAHR, Slump CH. The effects of probe placement on measured flow velocity in transcranial Doppler ultrasound imaging in-vitro and in-vivo experiments. In Bosch JG, Doyley MM, editors, Medical Imaging 2014: Ultrasonic Imaging and Tomography. Bellingham, Washington: SPIE. 2014. p. 904020-1-904020-7. (Proceedings of SPIE; 9040). doi: 10.1117/12.2042329