The effects of probe placement on measured flow velocity in transcranial Doppler ultrasound imaging in-vitro and in-vivo experiments

Daan L.K. de Jong, Aisha van den Abeelen, Joep Lagro, Jurgen A.H.R. Claassen, Cornelis H. Slump

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review


    The measurement of the blood flow in the middle cerebral artery (MCA) using transcranial Doppler ultrasound (US) imaging is clinically relevant for the study of cerebral autoregulation. Especially in the aging population, impairement of the autoregulation may coincide or relate to loss of perfusion and consequently loss of brain function. The cerebral autoregulation can be assessed by relating the blood pressure to the blood flow in the brain. Doppler US is a widely used, non-invasive method to measure the blood flow in the MCA. However, Doppler flow imaging is known to produce results that are dependent of the operator. The angle of the probe insonation with respect to the centerline of the blood vessel is a well known factor for output variability. In patients also the skull must be traversed and the MCA must be detected, influencing the US signal intensity. In this contribution we report two studies. We describe first an in-vitro setup to study the Doppler flow in a situation where the ground truth is known. Secondly, we report on a study with healthy volunteers where the effects of small probe displacements on the flow velocity signals are investigated. For the latter purpose, a special probe holder was designed to control the experiment.
    Original languageUndefined
    Title of host publicationMedical Imaging 2014: Ultrasonic Imaging and Tomography
    EditorsJ.G. Bosch, M.M. Doyley
    Place of PublicationBellingham, Washington
    Number of pages7
    ISBN (Print)978-0-8194-9835-9
    Publication statusPublished - 15 Feb 2014
    EventMedical Imaging 2014 - San Diego, United States
    Duration: 15 Feb 201420 Feb 2014

    Publication series

    NameProceedings of SPIE
    ISSN (Print)0277-786X


    ConferenceMedical Imaging 2014
    Country/TerritoryUnited States
    CitySan Diego


    • EWI-25331
    • flow set-up
    • transcranial Doppler
    • phantom design
    • METIS-309673
    • Cerebral blood flow velocity
    • IR-93015
    • In vitro
    • In vivo
    • Quantitative imaging

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