TY - JOUR
T1 - The Impact of Acute Exercise on Hemostasis and Angiogenesis Mediators in Patients With Continuous-Flow Left Ventricular Assist Devices
T2 - A Prospective Observational Pilot Study
AU - Chan, Chris H.H.
AU - Passmore, Margaret R.
AU - Tronstad, Oystein
AU - Seale, Helen
AU - Bouquet, Mahe
AU - White, Nicole
AU - Teruya, Jun
AU - Hogan, Airlie
AU - Platts, David
AU - Chan, Wandy
AU - Dashwood, Alexander M.
AU - McGiffin, David C.
AU - Maiorana, Andrew J.
AU - Hayward, Christopher S.
AU - Simmonds, Michael J.
AU - Tansley, Geoff D.
AU - Suen, Jacky Y.
AU - Fraser, John F.
AU - Meyns, Bart
AU - Fresiello, Libera
AU - Jacobs, Steven
N1 - Publisher Copyright:
Copyright © ASAIO 2024.
PY - 2025/1/1
Y1 - 2025/1/1
N2 - Impaired primary hemostasis and dysregulated angiogenesis, known as a two-hit hypothesis, are associated with gastrointestinal (GI) bleeding in patients with continuous-flow left ventricular assist devices (CF-LVADs). Exercise is known to influence hemostasis and angiogenesis in healthy individuals; however, little is known about the effect in patients with CF-LVADs. The objective of this prospective observational study was to determine whether acute exercise modulates two-hit hypothesis mediators associated with GI bleeding in patients with a CF-LVAD. Twenty-two patients with CF-LVADs performed acute exercise either on a cycle ergometer for approximately 10 minutes or on a treadmill for 30 minutes. Blood samples were taken pre- and post-exercise to analyze hemostatic and angiogenic biomarkers. Acute exercise resulted in an increased platelet count ( p < 0.00001) and platelet function (induced by adenosine diphosphate, p = 0.0087; TRAP-6, p = 0.0005; ristocetin, p = 0.0009). Additionally, high-molecular-weight vWF multimers ( p < 0.00001), vWF collagen-binding activity ( p = 0.0012), factor VIII ( p = 0.034), angiopoietin-1 ( p = 0.0026), and vascular endothelial growth factor ( p = 0.0041) all increased after acute exercise. This pilot work demonstrates that acute exercise modulated two-hit hypothesis mediators associated with GI bleeding in patients with CF-LVADs.
AB - Impaired primary hemostasis and dysregulated angiogenesis, known as a two-hit hypothesis, are associated with gastrointestinal (GI) bleeding in patients with continuous-flow left ventricular assist devices (CF-LVADs). Exercise is known to influence hemostasis and angiogenesis in healthy individuals; however, little is known about the effect in patients with CF-LVADs. The objective of this prospective observational study was to determine whether acute exercise modulates two-hit hypothesis mediators associated with GI bleeding in patients with a CF-LVAD. Twenty-two patients with CF-LVADs performed acute exercise either on a cycle ergometer for approximately 10 minutes or on a treadmill for 30 minutes. Blood samples were taken pre- and post-exercise to analyze hemostatic and angiogenic biomarkers. Acute exercise resulted in an increased platelet count ( p < 0.00001) and platelet function (induced by adenosine diphosphate, p = 0.0087; TRAP-6, p = 0.0005; ristocetin, p = 0.0009). Additionally, high-molecular-weight vWF multimers ( p < 0.00001), vWF collagen-binding activity ( p = 0.0012), factor VIII ( p = 0.034), angiopoietin-1 ( p = 0.0026), and vascular endothelial growth factor ( p = 0.0041) all increased after acute exercise. This pilot work demonstrates that acute exercise modulated two-hit hypothesis mediators associated with GI bleeding in patients with CF-LVADs.
KW - 2025 OA procedure
UR - http://www.scopus.com/inward/record.url?scp=85214054375&partnerID=8YFLogxK
U2 - 10.1097/MAT.0000000000002246
DO - 10.1097/MAT.0000000000002246
M3 - Article
C2 - 38833540
AN - SCOPUS:85214054375
SN - 1058-2916
VL - 71
SP - 11
EP - 20
JO - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JF - ASAIO journal (American Society for Artificial Internal Organs : 1992)
IS - 1
ER -