The Impact of Non-dopaminergic Medication on Quality of Life in Parkinson’s Disease

Nicol G.M. Oonk*, Kris L.L. Movig, Job van der Palen, Henk Willem Nijmeijer, Mirjam E. van Kesteren, Lucille D.A. Dorresteijn

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background and Objectives: Quality of life (QoL) in Parkinson’s disease (PD) depends on multiple factors. Due to PD treatment and accompanying, age-related or independent comorbidities, pill burden is often high. The relation of QoL and pharmacotherapy for comorbidities in PD has not been widely studied. This study investigated if and to what extent non-dopaminergic drugs are related to QoL in PD. Second, the impact of demographics and non-motor symptoms were evaluated. A better understanding of the impact of different non-dopaminergic drugs and polypharmacy on QoL will have added value in selecting appropriate (medication) interventions. Methods: In a cross-sectional analysis, medication prescription data of 209 PD patients were analyzed and grouped according to the Rx-Risk comorbidity index. QoL was measured using the PDQ-39 questionnaire. Non-motor symptoms were analyzed with the Non-Motor Symptoms questionnaire. Independent factors associated with a reduced QoL were identified with a multivariate linear regression analysis. Results: Non-dopaminergic drugs, subdivided into Rx-Risk comorbidity categories, were not associated with reduced QoL, except for the use of anti-epileptic drugs. However, using more daily non-dopaminergic drugs was also negatively associated with QoL, as well as female sex, increased PD severity, and more non-motor symptoms. Contraindicated non-dopaminergic medication was barely prescribed (0.4%). Conclusion: Non-dopaminergic drugs are frequently prescribed, and higher numbers are associated with impaired QoL in PD. However, when divided in drug types, only anti-epileptic drugs were negatively associated with QoL. In these patients, physicians might improve QoL by further optimizing the condition it was prescribed for (e.g., pain or anxiety), or managing of side effects. Trial registration: Netherlands Trial Register; NL4360.

Original languageEnglish
Pages (from-to)809-816
Number of pages8
JournalClinical Drug Investigation
Early online date10 Aug 2021
Publication statusPublished - Sep 2021


Dive into the research topics of 'The Impact of Non-dopaminergic Medication on Quality of Life in Parkinson’s Disease'. Together they form a unique fingerprint.

Cite this