The influence of cyclic loading on gentamicin release from acrylic bone cements

Johannes G.E. Hendriks; Daniëlle Neut; Jan G. Hazenberg; Gijsbertus J. Verkerke; Jim R. van Horn; Henny C. van der Mei; Henk J. Busscher

doi:10.1016/j.jbiomech.2004.05.018

The influence of cyclic loading on gentamicin release from acrylic bone cements

Johannes G.E. Hendriks, Daniëlle Neut, Jan G. Hazenberg, Gijsbertus J. Verkerke, Jim R. van Horn, Henny C. van der Mei, Henk J. Busscher^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

Abstract

Antibiotic-loaded acrylic bone cement is widely used in total joint replacement to reduce infections. Walking results in cyclic loading, which has been suggested to stimulate antibiotic release. The goal of this study is to compare antibiotic release from cyclically loaded bone cement with the release from unloaded bone cement. Two models of the frontal aspect of a femoral stem were cemented with CMW 1 Radiopaque G, Palacos R-G and Palamed G. Both were immersed in water, and the gentamicin concentration in the water was monitored. One model was cyclically loaded at 5Hz during immersion achieving physiological stresses in the bone cement mantle. After 10.8×10⁶cycles, initial release of gentamicin from Palamed G was increased significantly for loaded over unloaded, but not from CMW 1 Radiopaque G and Palacos R-G.

Original language	English
Pages (from-to)	953-957
Number of pages	5
Journal	Journal of biomechanics
Volume	38
Issue number	4
DOIs	https://doi.org/10.1016/j.jbiomech.2004.05.018
Publication status	Published - Apr 2005
Externally published	Yes

Keywords

Acrylic bone cement
Antibiotic release
Cyclic loading

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10.1016/j.jbiomech.2004.05.018

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@article{305388352b234727a2cb74372c105e2e,

title = "The influence of cyclic loading on gentamicin release from acrylic bone cements",

abstract = "Antibiotic-loaded acrylic bone cement is widely used in total joint replacement to reduce infections. Walking results in cyclic loading, which has been suggested to stimulate antibiotic release. The goal of this study is to compare antibiotic release from cyclically loaded bone cement with the release from unloaded bone cement. Two models of the frontal aspect of a femoral stem were cemented with CMW 1 Radiopaque G, Palacos R-G and Palamed G. Both were immersed in water, and the gentamicin concentration in the water was monitored. One model was cyclically loaded at 5Hz during immersion achieving physiological stresses in the bone cement mantle. After 10.8×106cycles, initial release of gentamicin from Palamed G was increased significantly for loaded over unloaded, but not from CMW 1 Radiopaque G and Palacos R-G.",

keywords = "Acrylic bone cement, Antibiotic release, Cyclic loading",

author = "Hendriks, {Johannes G.E.} and Dani{\"e}lle Neut and Hazenberg, {Jan G.} and Verkerke, {Gijsbertus J.} and {van Horn}, {Jim R.} and {van der Mei}, {Henny C.} and Busscher, {Henk J.}",

year = "2005",

month = apr,

doi = "10.1016/j.jbiomech.2004.05.018",

language = "English",

volume = "38",

pages = "953--957",

journal = "Journal of biomechanics",

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publisher = "Elsevier Ltd",

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TY - JOUR

T1 - The influence of cyclic loading on gentamicin release from acrylic bone cements

AU - Hendriks, Johannes G.E.

AU - Neut, Daniëlle

AU - Hazenberg, Jan G.

AU - Verkerke, Gijsbertus J.

AU - van Horn, Jim R.

AU - van der Mei, Henny C.

AU - Busscher, Henk J.

PY - 2005/4

Y1 - 2005/4

N2 - Antibiotic-loaded acrylic bone cement is widely used in total joint replacement to reduce infections. Walking results in cyclic loading, which has been suggested to stimulate antibiotic release. The goal of this study is to compare antibiotic release from cyclically loaded bone cement with the release from unloaded bone cement. Two models of the frontal aspect of a femoral stem were cemented with CMW 1 Radiopaque G, Palacos R-G and Palamed G. Both were immersed in water, and the gentamicin concentration in the water was monitored. One model was cyclically loaded at 5Hz during immersion achieving physiological stresses in the bone cement mantle. After 10.8×106cycles, initial release of gentamicin from Palamed G was increased significantly for loaded over unloaded, but not from CMW 1 Radiopaque G and Palacos R-G.

AB - Antibiotic-loaded acrylic bone cement is widely used in total joint replacement to reduce infections. Walking results in cyclic loading, which has been suggested to stimulate antibiotic release. The goal of this study is to compare antibiotic release from cyclically loaded bone cement with the release from unloaded bone cement. Two models of the frontal aspect of a femoral stem were cemented with CMW 1 Radiopaque G, Palacos R-G and Palamed G. Both were immersed in water, and the gentamicin concentration in the water was monitored. One model was cyclically loaded at 5Hz during immersion achieving physiological stresses in the bone cement mantle. After 10.8×106cycles, initial release of gentamicin from Palamed G was increased significantly for loaded over unloaded, but not from CMW 1 Radiopaque G and Palacos R-G.

KW - Acrylic bone cement

KW - Antibiotic release

KW - Cyclic loading

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U2 - 10.1016/j.jbiomech.2004.05.018

DO - 10.1016/j.jbiomech.2004.05.018

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C2 - 15713316

SN - 0021-9290

VL - 38

SP - 953

EP - 957

JO - Journal of biomechanics

JF - Journal of biomechanics

IS - 4

ER -

The influence of cyclic loading on gentamicin release from acrylic bone cements

Abstract

Keywords

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