The cable-in-conduit superconductors for the ITER coils have operating current in excess of 40 kA and function under last ramp conditions and fields up to 13 T. The transverse Lorentz force acting on strands may reduce the effective contact resistance between strands in the cable and as a consequence, the coupling loss will increase. This influence is investigated with a sub-size jacketed cable having 81 Cr-coated Nb3Sn strands. The AC loss is measured with a sinusoidal and trapezoidal magnetic field superimposed to a stationary background field of 1 or 2 T while the cable carries a constant transport current up to about 30 kA. The AC loss is determined by a pick-up coil system and partly with a calorimeter for calibration purposes. The nτ at 0 current declines after cyclic loading, from 9 ms in the virgin state to 2 ms after several loads. The increase of the interstrand coupling loss due to Lorentz effects, accompanied by resistance-hysteresis and relaxation effects as observed in the loss are discussed. The total loss increases considerably due to interference of transport current and induced coupling currents with rising transport current and DC field.