The Influence of Mechanical Rubbing on the Dissolution of Blood Clots

Dalia Mahdy; Nabila Hamdi; Sarah Hesham; Ahmed El Sharkawy; Islam S.M. Khalil

doi:10.1109/EMBC.2018.8512646

The Influence of Mechanical Rubbing on the Dissolution of Blood Clots

Dalia Mahdy, Nabila Hamdi, Sarah Hesham, Ahmed El Sharkawy, Islam S.M. Khalil

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

3 Citations (Scopus)

Abstract

Mechanical rubbing of blood clots is a potential minimally-invasive method for clearing clogged blood vessels. In this work, we investigate the influence of the interaction of the tip of a helical robot with blood clots. This interaction enables the dissolution of the blood clot and the release of the entrapped red blood cells and platelets from its three-dimensional fibrin fiber network. We analyze the pre- and post-conditions of the blood clots following 40 minutes of mechanical rubbing, under the influence of a rotating magnetic field in the frequency range of 20 Hz to 45 Hz. Our measurements show that the weight of the blood clots is decreased by 22.5 ± 11.1% at frequency of 25 Hz. We also validate the influence of mechanical rubbing using cell count and spectrophotometric analysis on phosphate buffered saline samples past the robot and the clot. The maximum cell count is measured as 654 ± 108 × 10⁴ cells/m1 and 54 ± 12 × 10⁴ cells/m1, whereas the absorbance is measured as 4. 35 × 10^-6 mol and 1. 05 × 10^-6 mol under the influence of mechanical rubbing and without mechanical rubbing, respectively.

Original language	English
Title of host publication	40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
Place of Publication	Piscataway, NJ
Publisher	IEEE
Pages	1660-1663
Number of pages	4
ISBN (Electronic)	978-1-5386-3646-6, 978-1-5386-3645-9 (USB)
ISBN (Print)	978-1-5386-3647-3
DOIs	https://doi.org/10.1109/EMBC.2018.8512646
Publication status	Published - 26 Oct 2018
Externally published	Yes
Event	40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 - Hawaii Convention Center, Honolulu, United States Duration: 17 Jul 2018 → 21 Jul 2018 Conference number: 40 https://embc.embs.org/2018/

Publication series

Name	Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Publisher	IEEE
Volume	2018
ISSN (Print)	1557-170X
ISSN (Electronic)	1558-4615

Conference

Conference	40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
Abbreviated title	EMBC 2018
Country/Territory	United States
City	Honolulu
Period	17/07/18 → 21/07/18
Internet address	https://embc.embs.org/2018/

Keywords

n/a OA procedure

Access to Document

10.1109/EMBC.2018.8512646

Cite this

Mahdy, D., Hamdi, N., Hesham, S., Sharkawy, A. E., & Khalil, I. S. M. (2018). The Influence of Mechanical Rubbing on the Dissolution of Blood Clots. In 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 (pp. 1660-1663). Article 8512646 (Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC); Vol. 2018). IEEE. https://doi.org/10.1109/EMBC.2018.8512646

Mahdy, Dalia ; Hamdi, Nabila ; Hesham, Sarah et al. / The Influence of Mechanical Rubbing on the Dissolution of Blood Clots. 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Piscataway, NJ : IEEE, 2018. pp. 1660-1663 (Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)).

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abstract = "Mechanical rubbing of blood clots is a potential minimally-invasive method for clearing clogged blood vessels. In this work, we investigate the influence of the interaction of the tip of a helical robot with blood clots. This interaction enables the dissolution of the blood clot and the release of the entrapped red blood cells and platelets from its three-dimensional fibrin fiber network. We analyze the pre- and post-conditions of the blood clots following 40 minutes of mechanical rubbing, under the influence of a rotating magnetic field in the frequency range of 20 Hz to 45 Hz. Our measurements show that the weight of the blood clots is decreased by 22.5 ± 11.1% at frequency of 25 Hz. We also validate the influence of mechanical rubbing using cell count and spectrophotometric analysis on phosphate buffered saline samples past the robot and the clot. The maximum cell count is measured as 654 ± 108 × 104 cells/m1 and 54 ± 12 × 104 cells/m1, whereas the absorbance is measured as 4. 35 × 10-6 mol and 1. 05 × 10-6 mol under the influence of mechanical rubbing and without mechanical rubbing, respectively.",

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author = "Dalia Mahdy and Nabila Hamdi and Sarah Hesham and Sharkawy, {Ahmed El} and Khalil, {Islam S.M.}",

note = "Funding Information: The authors are affiliated with the German University in Cairo, Egypt. This work was supported by the Science and Technology Development Fund in Egypt (No. 23016) and the DAAD-BMBF funding project. Publisher Copyright: {\textcopyright} 2018 IEEE.; 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018, EMBC 2018 ; Conference date: 17-07-2018 Through 21-07-2018",

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Mahdy, D, Hamdi, N, Hesham, S, Sharkawy, AE & Khalil, ISM 2018, The Influence of Mechanical Rubbing on the Dissolution of Blood Clots. in 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018., 8512646, Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), vol. 2018, IEEE, Piscataway, NJ, pp. 1660-1663, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018, Honolulu, Hawaii, United States, 17/07/18. https://doi.org/10.1109/EMBC.2018.8512646

The Influence of Mechanical Rubbing on the Dissolution of Blood Clots. / Mahdy, Dalia; Hamdi, Nabila; Hesham, Sarah et al.
40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Piscataway, NJ: IEEE, 2018. p. 1660-1663 8512646 (Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC); Vol. 2018).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

TY - GEN

T1 - The Influence of Mechanical Rubbing on the Dissolution of Blood Clots

AU - Mahdy, Dalia

AU - Hamdi, Nabila

AU - Hesham, Sarah

AU - Sharkawy, Ahmed El

AU - Khalil, Islam S.M.

N1 - Conference code: 40

PY - 2018/10/26

Y1 - 2018/10/26

N2 - Mechanical rubbing of blood clots is a potential minimally-invasive method for clearing clogged blood vessels. In this work, we investigate the influence of the interaction of the tip of a helical robot with blood clots. This interaction enables the dissolution of the blood clot and the release of the entrapped red blood cells and platelets from its three-dimensional fibrin fiber network. We analyze the pre- and post-conditions of the blood clots following 40 minutes of mechanical rubbing, under the influence of a rotating magnetic field in the frequency range of 20 Hz to 45 Hz. Our measurements show that the weight of the blood clots is decreased by 22.5 ± 11.1% at frequency of 25 Hz. We also validate the influence of mechanical rubbing using cell count and spectrophotometric analysis on phosphate buffered saline samples past the robot and the clot. The maximum cell count is measured as 654 ± 108 × 104 cells/m1 and 54 ± 12 × 104 cells/m1, whereas the absorbance is measured as 4. 35 × 10-6 mol and 1. 05 × 10-6 mol under the influence of mechanical rubbing and without mechanical rubbing, respectively.

AB - Mechanical rubbing of blood clots is a potential minimally-invasive method for clearing clogged blood vessels. In this work, we investigate the influence of the interaction of the tip of a helical robot with blood clots. This interaction enables the dissolution of the blood clot and the release of the entrapped red blood cells and platelets from its three-dimensional fibrin fiber network. We analyze the pre- and post-conditions of the blood clots following 40 minutes of mechanical rubbing, under the influence of a rotating magnetic field in the frequency range of 20 Hz to 45 Hz. Our measurements show that the weight of the blood clots is decreased by 22.5 ± 11.1% at frequency of 25 Hz. We also validate the influence of mechanical rubbing using cell count and spectrophotometric analysis on phosphate buffered saline samples past the robot and the clot. The maximum cell count is measured as 654 ± 108 × 104 cells/m1 and 54 ± 12 × 104 cells/m1, whereas the absorbance is measured as 4. 35 × 10-6 mol and 1. 05 × 10-6 mol under the influence of mechanical rubbing and without mechanical rubbing, respectively.

KW - n/a OA procedure

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M3 - Conference contribution

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SN - 978-1-5386-3647-3

T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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BT - 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018

PB - IEEE

CY - Piscataway, NJ

T2 - 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018

Y2 - 17 July 2018 through 21 July 2018

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Mahdy D, Hamdi N, Hesham S, Sharkawy AE, Khalil ISM. The Influence of Mechanical Rubbing on the Dissolution of Blood Clots. In 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Piscataway, NJ: IEEE. 2018. p. 1660-1663. 8512646. (Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)). doi: 10.1109/EMBC.2018.8512646

The Influence of Mechanical Rubbing on the Dissolution of Blood Clots

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