The Influence of Mechanical Rubbing on the Dissolution of Blood Clots

Dalia Mahdy, Nabila Hamdi, Sarah Hesham, Ahmed El Sharkawy, Islam S.M. Khalil

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

2 Citations (Scopus)

Abstract

Mechanical rubbing of blood clots is a potential minimally-invasive method for clearing clogged blood vessels. In this work, we investigate the influence of the interaction of the tip of a helical robot with blood clots. This interaction enables the dissolution of the blood clot and the release of the entrapped red blood cells and platelets from its three-dimensional fibrin fiber network. We analyze the pre- and post-conditions of the blood clots following 40 minutes of mechanical rubbing, under the influence of a rotating magnetic field in the frequency range of 20 Hz to 45 Hz. Our measurements show that the weight of the blood clots is decreased by 22.5 ± 11.1% at frequency of 25 Hz. We also validate the influence of mechanical rubbing using cell count and spectrophotometric analysis on phosphate buffered saline samples past the robot and the clot. The maximum cell count is measured as 654 ± 108 × 104 cells/m1 and 54 ± 12 × 104 cells/m1, whereas the absorbance is measured as 4. 35 × 10-6 mol and 1. 05 × 10-6 mol under the influence of mechanical rubbing and without mechanical rubbing, respectively.

Original languageEnglish
Title of host publication40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
Place of PublicationPiscataway, NJ
PublisherIEEE
Pages1660-1663
Number of pages4
ISBN (Electronic)978-1-5386-3646-6, 978-1-5386-3645-9 (USB)
ISBN (Print)978-1-5386-3647-3
DOIs
Publication statusPublished - 26 Oct 2018
Externally publishedYes
Event40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 - Hawaii Convention Center, Honolulu, United States
Duration: 17 Jul 201821 Jul 2018
Conference number: 40
https://embc.embs.org/2018/

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
PublisherIEEE
Volume2018
ISSN (Print)1557-170X
ISSN (Electronic)1558-4615

Conference

Conference40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
Abbreviated titleEMBC 2018
Country/TerritoryUnited States
CityHonolulu
Period17/07/1821/07/18
Internet address

Keywords

  • n/a OA procedure

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