The initial systolic time interval in patients with spinal cord injury measured with impedance cardiography

Femke Hoekstra*, Orjan G. Martinsen, Rudolf M. Verdaasdonk, Thomas W.J. Janssen, Jan H. Meijer

*Corresponding author for this work

Research output: Contribution to journalConference articleAcademicpeer-review

2 Citations (Scopus)
22 Downloads (Pure)


The Initial Systolic Time Interval (ISTI), obtained from the electrocardiogram and impedance cardiogram, is considered to be a measure for the time delay between the electrical and mechanical activity of the heart. This time delay is influenced by the sympathetic nerve system. Therefore, an observational study was performed in a group of patients (SCI) with spinal cord injuries. The relationship between the ISTI and the total heart cycle (RR-interval) was established by varying the RR-interval using an exercise stimulus to increase the heart rate. The slope of this relationship was observed to be significantly higher in the SCI-group as compared with a control group, although there was no difference in ISTI in the range of common heart rates during the test between the groups. This slope and the ISTI was observed to be significantly different in an acute patient having a recent spinal cord injury at a high level. Because of the variety in injury levels and incompleteness of the injuries further, more specific research is necessary to draw decisive conclusions with respect to the contribution of autonomic nervous control on the ISTI in SCI, although the present observations are notable.

Original languageEnglish
Article number012025
JournalJournal of physics: Conference series
Issue number1
Publication statusPublished - 1 Jan 2012
Externally publishedYes
Event1st Latin-American Conference on Bioimpedance, CLABIO 2012 - Joinville, Brazil
Duration: 6 Nov 20129 Nov 2012
Conference number: 1


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