Abstract
Background: COPD and chronic heart failure (CHF) commonly co-exist and share symptoms, which complicates disease management. It is unclear how symptom deterioration of COPD and CHF inter(re)act.
Aim: Assess the interplay between COPD and CHF deterioration at group and individual level.
Methods: Total daily COPD (0-7) and CHF (0-6) symptom scores, based on increased symptoms reported in 1-year daily diaries (ERJ 2019 54:1802134), were used to assess the COPD-CHF interplay at group and individual level using two mixed models.
Results: 33 patients (72±8 years, 24 men (73%)) were included.
Model 1 shows that, at group level, increased CHF symptom score predicts next day’s COPD symptoms (p=0.02). This was not consistently observed at individual level due to the large variation in the direction and strength of the individual-level associations (Fig 1A).
Model 2 shows that, at group level, increased COPD symptom score predicts next day’s CHF symptoms (p<0.001). Less variation was observed in the direction of the model 2 individual-level associations, still, they differed in strength from no association to strong positive associations (Fig 1B).
Conclusions: At group level, CHF deterioration predicts an increase in next day’s COPD symptom score as well as vice versa. Yet, at individual level, only the group-level conclusion of model 2 holds. Increased COPD symptoms thus consistently predict deterioration of CHF the next day within individual patients.
Aim: Assess the interplay between COPD and CHF deterioration at group and individual level.
Methods: Total daily COPD (0-7) and CHF (0-6) symptom scores, based on increased symptoms reported in 1-year daily diaries (ERJ 2019 54:1802134), were used to assess the COPD-CHF interplay at group and individual level using two mixed models.
Results: 33 patients (72±8 years, 24 men (73%)) were included.
Model 1 shows that, at group level, increased CHF symptom score predicts next day’s COPD symptoms (p=0.02). This was not consistently observed at individual level due to the large variation in the direction and strength of the individual-level associations (Fig 1A).
Model 2 shows that, at group level, increased COPD symptom score predicts next day’s CHF symptoms (p<0.001). Less variation was observed in the direction of the model 2 individual-level associations, still, they differed in strength from no association to strong positive associations (Fig 1B).
Conclusions: At group level, CHF deterioration predicts an increase in next day’s COPD symptom score as well as vice versa. Yet, at individual level, only the group-level conclusion of model 2 holds. Increased COPD symptoms thus consistently predict deterioration of CHF the next day within individual patients.
Original language | English |
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Article number | PA3021 |
Number of pages | 3 |
Journal | European respiratory journal |
Volume | 64 |
Issue number | Suppl. 68 |
DOIs | |
Publication status | Published - Sept 2024 |
Event | ERS international congress 2024 - Vienna, Austria Duration: 7 Sept 2024 → 11 Sept 2024 |
Keywords
- NLA