The magic angle effect can (partially) explain load-induced increases in meniscal T2 and T1rho

Valentina Mazzoli, Danny Tsui, Larry de Graaf, Klaas Nicolay, Andre M. Sprengers, Dennis Janssen, Nico Verdonschot, Aart J. Nederveen, Gustav J. Strijkers

Research output: Contribution to conferenceAbstractOther research output

Abstract

Often, knee injury and disorders are caused by or lead to abnormal biomechanical loading patterns in the knee joint menisci. Quantitative information on in vivo loading patterns is therefore in high demand to evaluate therapy and prevent further damage. T1ρ and T2 in meniscus were shown to increase upon application of compressive load, although the mechanisms leading to changes remain unclear. In this work we apply compressive load on the meniscus of volunteers and one cadaver and show that compression-induced internal fiber reorganization may manifest as the magic angle effect, which may be responsible for load-induced T2 and T1ρ increases.
Original languageEnglish
Publication statusPublished - 22 Apr 2017
Event25th ISMRM Annual Meeting & Exhibition 2017 - Hawai'i Convention Center, Honolulu, United States
Duration: 22 Apr 201727 Apr 2017
Conference number: 25
https://www.ismrm.org/2017-annual-meeting-exhibition/

Conference

Conference25th ISMRM Annual Meeting & Exhibition 2017
Abbreviated titleISMRM 2017
CountryUnited States
CityHonolulu
Period22/04/1727/04/17
Internet address

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Knee Injuries
Knee Joint
Cadaver
Volunteers
Meniscus
Therapeutics

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Mazzoli, V., Tsui, D., de Graaf, L., Nicolay, K., Sprengers, A. M., Janssen, D., ... Strijkers, G. J. (2017). The magic angle effect can (partially) explain load-induced increases in meniscal T2 and T1rho. Abstract from 25th ISMRM Annual Meeting & Exhibition 2017, Honolulu, United States.
Mazzoli, Valentina ; Tsui, Danny ; de Graaf, Larry ; Nicolay, Klaas ; Sprengers, Andre M. ; Janssen, Dennis ; Verdonschot, Nico ; Nederveen, Aart J. ; Strijkers, Gustav J. / The magic angle effect can (partially) explain load-induced increases in meniscal T2 and T1rho. Abstract from 25th ISMRM Annual Meeting & Exhibition 2017, Honolulu, United States.
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title = "The magic angle effect can (partially) explain load-induced increases in meniscal T2 and T1rho",
abstract = "Often, knee injury and disorders are caused by or lead to abnormal biomechanical loading patterns in the knee joint menisci. Quantitative information on in vivo loading patterns is therefore in high demand to evaluate therapy and prevent further damage. T1ρ and T2 in meniscus were shown to increase upon application of compressive load, although the mechanisms leading to changes remain unclear. In this work we apply compressive load on the meniscus of volunteers and one cadaver and show that compression-induced internal fiber reorganization may manifest as the magic angle effect, which may be responsible for load-induced T2 and T1ρ increases.",
author = "Valentina Mazzoli and Danny Tsui and {de Graaf}, Larry and Klaas Nicolay and Sprengers, {Andre M.} and Dennis Janssen and Nico Verdonschot and Nederveen, {Aart J.} and Strijkers, {Gustav J.}",
year = "2017",
month = "4",
day = "22",
language = "English",
note = "25th ISMRM Annual Meeting & Exhibition 2017, ISMRM 2017 ; Conference date: 22-04-2017 Through 27-04-2017",
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Mazzoli, V, Tsui, D, de Graaf, L, Nicolay, K, Sprengers, AM, Janssen, D, Verdonschot, N, Nederveen, AJ & Strijkers, GJ 2017, 'The magic angle effect can (partially) explain load-induced increases in meniscal T2 and T1rho' 25th ISMRM Annual Meeting & Exhibition 2017, Honolulu, United States, 22/04/17 - 27/04/17, .

The magic angle effect can (partially) explain load-induced increases in meniscal T2 and T1rho. / Mazzoli, Valentina; Tsui, Danny; de Graaf, Larry; Nicolay, Klaas; Sprengers, Andre M.; Janssen, Dennis; Verdonschot, Nico; Nederveen, Aart J.; Strijkers, Gustav J.

2017. Abstract from 25th ISMRM Annual Meeting & Exhibition 2017, Honolulu, United States.

Research output: Contribution to conferenceAbstractOther research output

TY - CONF

T1 - The magic angle effect can (partially) explain load-induced increases in meniscal T2 and T1rho

AU - Mazzoli, Valentina

AU - Tsui, Danny

AU - de Graaf, Larry

AU - Nicolay, Klaas

AU - Sprengers, Andre M.

AU - Janssen, Dennis

AU - Verdonschot, Nico

AU - Nederveen, Aart J.

AU - Strijkers, Gustav J.

PY - 2017/4/22

Y1 - 2017/4/22

N2 - Often, knee injury and disorders are caused by or lead to abnormal biomechanical loading patterns in the knee joint menisci. Quantitative information on in vivo loading patterns is therefore in high demand to evaluate therapy and prevent further damage. T1ρ and T2 in meniscus were shown to increase upon application of compressive load, although the mechanisms leading to changes remain unclear. In this work we apply compressive load on the meniscus of volunteers and one cadaver and show that compression-induced internal fiber reorganization may manifest as the magic angle effect, which may be responsible for load-induced T2 and T1ρ increases.

AB - Often, knee injury and disorders are caused by or lead to abnormal biomechanical loading patterns in the knee joint menisci. Quantitative information on in vivo loading patterns is therefore in high demand to evaluate therapy and prevent further damage. T1ρ and T2 in meniscus were shown to increase upon application of compressive load, although the mechanisms leading to changes remain unclear. In this work we apply compressive load on the meniscus of volunteers and one cadaver and show that compression-induced internal fiber reorganization may manifest as the magic angle effect, which may be responsible for load-induced T2 and T1ρ increases.

M3 - Abstract

ER -

Mazzoli V, Tsui D, de Graaf L, Nicolay K, Sprengers AM, Janssen D et al. The magic angle effect can (partially) explain load-induced increases in meniscal T2 and T1rho. 2017. Abstract from 25th ISMRM Annual Meeting & Exhibition 2017, Honolulu, United States.