The magic angle effect can (partially) explain load-induced increases in meniscal T2 and T1rho

Valentina Mazzoli, Danny Tsui, Larry de Graaf, Klaas Nicolay, Andre M. Sprengers, Dennis Janssen, Nico Verdonschot, Aart J. Nederveen, Gustav J. Strijkers

    Research output: Contribution to conferenceAbstractOther research output


    Often, knee injury and disorders are caused by or lead to abnormal biomechanical loading patterns in the knee joint menisci. Quantitative information on in vivo loading patterns is therefore in high demand to evaluate therapy and prevent further damage. T1ρ and T2 in meniscus were shown to increase upon application of compressive load, although the mechanisms leading to changes remain unclear. In this work we apply compressive load on the meniscus of volunteers and one cadaver and show that compression-induced internal fiber reorganization may manifest as the magic angle effect, which may be responsible for load-induced T2 and T1ρ increases.
    Original languageEnglish
    Publication statusPublished - 22 Apr 2017
    Event25th ISMRM Annual Meeting & Exhibition 2017 - Hawai'i Convention Center, Honolulu, United States
    Duration: 22 Apr 201727 Apr 2017
    Conference number: 25


    Conference25th ISMRM Annual Meeting & Exhibition 2017
    Abbreviated titleISMRM 2017
    Country/TerritoryUnited States
    Internet address


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