The neural code in developing cultured networks: experiments and advanced simulation models

Wim Rutten; T. Gritsun; Irina Stoyanova; Jakob le Feber

The neural code in developing cultured networks: experiments and advanced simulation models

Wim Rutten, T. Gritsun, Irina Stoyanova, Jakob le Feber

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

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Abstract

Understanding the neural code of cultured neuronal networks may help to forward our understanding of human brain processes.The most striking property of spontaneously firing cultures is their regular bursting activity, a burst being defined as synchronized firing of groups of neurons spread throughout the entire network. The regularity of bursting may change gradually with time, typically being stable over hours (Stegenga et al. 2008). Cultured cortical networks composed of many thousands of neurons show bursting behavior starting from the end of the first week in vitro. Bursts can be characterized by both intraburst parameters (burst shape, maximum firing rate, leading and trailing edge steepness, etc.) and interburst parameters (statistics, stability of burst rates) (Van Pelt et al. 2004; Wagenaar et al. 2006). Not only the temporal burst characteristics develop with time. Also, spatial burst propagation patterns, socalled ‘’burst waves’’, change with age of the network.

Original language	Undefined
Title of host publication	8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012
Place of Publication	Tuebingen
Publisher	NMI University Tuebingen
Pages	40-42
Number of pages	3
ISBN (Print)	2194-5519
Publication status	Published - 10 Jul 2012
Event	8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012 - Reutlingen, Germany Duration: 10 Jul 2012 → 13 Jul 2012 Conference number: 8

Publication series

Name	MEA Proceedings
Publisher	NMI University Tuebingen
ISSN (Print)	2194-5519

Conference

Conference	8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012
Abbreviated title	MEA
Country/Territory	Germany
City	Reutlingen
Period	10/07/12 → 13/07/12

Keywords

BSS-Neurotechnology and cellular engineering
EWI-22618
METIS-296159
IR-84098
Cultured neuronal networks
In vitro

Access to Document

http://eprints.eemcs.utwente.nl/secure2/22618/01/MEAMeeting_2012_Wim_1569579739.pdf

Cite this

Rutten, W., Gritsun, T., Stoyanova, I., & le Feber, J. (2012). The neural code in developing cultured networks: experiments and advanced simulation models. In 8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012 (pp. 40-42). (MEA Proceedings). NMI University Tuebingen. http://eprints.eemcs.utwente.nl/secure2/22618/01/MEAMeeting_2012_Wim_1569579739.pdf

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abstract = "Understanding the neural code of cultured neuronal networks may help to forward our understanding of human brain processes.The most striking property of spontaneously firing cultures is their regular bursting activity, a burst being defined as synchronized firing of groups of neurons spread throughout the entire network. The regularity of bursting may change gradually with time, typically being stable over hours (Stegenga et al. 2008). Cultured cortical networks composed of many thousands of neurons show bursting behavior starting from the end of the first week in vitro. Bursts can be characterized by both intraburst parameters (burst shape, maximum firing rate, leading and trailing edge steepness, etc.) and interburst parameters (statistics, stability of burst rates) (Van Pelt et al. 2004; Wagenaar et al. 2006). Not only the temporal burst characteristics develop with time. Also, spatial burst propagation patterns, socalled {\textquoteleft}{\textquoteright}burst waves{\textquoteright}{\textquoteright}, change with age of the network.",

keywords = "BSS-Neurotechnology and cellular engineering, EWI-22618, METIS-296159, IR-84098, Cultured neuronal networks, In vitro",

author = "Wim Rutten and T. Gritsun and Irina Stoyanova and {le Feber}, Jakob",

year = "2012",

month = jul,

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isbn = "2194-5519",

series = "MEA Proceedings",

publisher = "NMI University Tuebingen",

pages = "40--42",

booktitle = "8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012",

note = "8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012 ; Conference date: 10-07-2012 Through 13-07-2012",

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Rutten, W, Gritsun, T, Stoyanova, I & le Feber, J 2012, The neural code in developing cultured networks: experiments and advanced simulation models. in 8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012. MEA Proceedings, NMI University Tuebingen, Tuebingen, pp. 40-42, 8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012, Reutlingen, Germany, 10/07/12. <http://eprints.eemcs.utwente.nl/secure2/22618/01/MEAMeeting_2012_Wim_1569579739.pdf>

The neural code in developing cultured networks: experiments and advanced simulation models. / Rutten, Wim; Gritsun, T.; Stoyanova, Irina et al.
8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012. Tuebingen: NMI University Tuebingen, 2012. p. 40-42 (MEA Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

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