The neural code in developing cultured networks: experiments and advanced simulation models

Wim Rutten, T. Gritsun, Irina Stoyanova, Jakob le Feber

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic


    Understanding the neural code of cultured neuronal networks may help to forward our understanding of human brain processes.The most striking property of spontaneously firing cultures is their regular bursting activity, a burst being defined as synchronized firing of groups of neurons spread throughout the entire network. The regularity of bursting may change gradually with time, typically being stable over hours (Stegenga et al. 2008). Cultured cortical networks composed of many thousands of neurons show bursting behavior starting from the end of the first week in vitro. Bursts can be characterized by both intraburst parameters (burst shape, maximum firing rate, leading and trailing edge steepness, etc.) and interburst parameters (statistics, stability of burst rates) (Van Pelt et al. 2004; Wagenaar et al. 2006). Not only the temporal burst characteristics develop with time. Also, spatial burst propagation patterns, socalled ‘’burst waves’’, change with age of the network.
    Original languageUndefined
    Title of host publication8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012
    Place of PublicationTuebingen
    PublisherNMI University Tuebingen
    Number of pages3
    ISBN (Print)2194-5519
    Publication statusPublished - 10 Jul 2012
    Event8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012 - Reutlingen, Germany
    Duration: 10 Jul 201213 Jul 2012
    Conference number: 8

    Publication series

    NameMEA Proceedings
    PublisherNMI University Tuebingen
    ISSN (Print)2194-5519


    Conference8th International Meeting on Substrate-Integrated Microelectrode Arrays, MEA 2012
    Abbreviated titleMEA


    • BSS-Neurotechnology and cellular engineering
    • EWI-22618
    • METIS-296159
    • IR-84098
    • Cultured neuronal networks
    • In vitro

    Cite this