The Patient Simple Clinical Colitis Activity Index (P-SCCAI) can detect ulcerative colitis (UC) disease activity in remission: A comparison of the P-SCCAI with clinician-based SCCAI and biological markers

Floor Bennebroek Evertsz, Pythia T. Nieuwkerk, Pieter C.F. Stokkers, Cyriel Y. Ponsioen, Claudi L.H. Bockting, Robbert Sanderman, Mirjam A.G. Sprangers

Research output: Contribution to journalArticleAcademicpeer-review

49 Citations (Scopus)

Abstract

Aim To develop a patient-based Simple Clinical Colitis Activity Index (P-SCCAI) of ulcerative colitis (UC) activity and to compare it with the clinician-based SCCAI, C-reactive protein (CRP) and Physician's Global Assessment (PGA) of UC activity. Monitoring UC activity may give patients disease control and prevent unnecessary examinations. Methods Consecutive UC patients randomly completed the P-SCCAI either before or after consultation. Gastroenterologists assessed patients' UC activity on the same day. Overall agreement between SCCAI and P-SCCAI was calculated with Spearman's Rho and Mann–Whitney U test. Agreement regarding active disease versus remission and agreement at domain level were calculated by percent agreement and kappa (κ). Results 149 (response rate 84.7%) UC patients participated. P-SCCAI and SCCAI showed a large correlation (rs = 0.79). The medians (IQR) of the P-SCCAI (3.78;0–15) tended to be higher than those of the SCCAI (2.86;0–13), although this difference did not reach statistical significance (z = 1.71| p = 0.088). In 77% of the cases the difference between clinicians' and patients' scores was not clinically different (i.e. ≤ 2). Percentage agreement between clinicians and patients, judging UC as active or in remission, was 87%, rs = 0.66, κ = 0.66, indicating a substantial agreement. In general patients tended to report more physical symptoms than clinicians. C-Reactive protein (CRP) was found to have a significant association with both P-SCCAI and SCCAI (κ = 0.32, κ = 0.39 respectively) as was PGA (κ = 0.73 for both indices). Conclusions The P-SCCAI is a promising tool given its substantial agreement with the SCCAI and its feasibility. Therefore, P-SCCAI can complement SCCAI in clinical care and research
Original languageEnglish
Pages (from-to)890-900
JournalJournal of Crohn's and Colitis
Volume7
Issue number11
Publication statusPublished - 2013

Keywords

  • METIS-304987
  • IR-91714

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