The pedunculopontine nucleus as alternative target for deep brain stimulation

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

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Abstract

Parkinson’s disease (PD) is a neurodegenerative disease associated with motor and nonmotor symptoms. Deep brain stimulation (DBS) is a surgical treatment where an electrode is implanted in a certain area in the brain. In PD this is mostly done in the subthalamic nucleus (STN) or the globus pallidus interna (GPi). High frequency stimulation (~130 Hz) is often a successful treatment. The pedunculopontine nucleus (PPN) has recently been suggested as a new therapeutic target for DBS, particularly for patients with severe gait and postural impairment [2]. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in STN [2]. Despite real therapeutic successes, the fundamental physiological mechanisms underlying the effect of DBS are still not understood. To get a better understanding of PPN stimulation we construct a computational model for PPN Type I neurons.
Original languageUndefined
Title of host publicationProceedings of the 4th Annual symposium of the IEEE-EMBS Benelux Chapter
Place of PublicationEnschede
PublisherTwente University Press (TUP)
Pages27
Number of pages1
ISBN (Print)978-90-365-2933-4
Publication statusPublished - 24 Nov 2009
Event4th Annual Symposium of the Benelux Chapter of the IEEE Engineering in Medicine and Biology Society (IEEE-EMBS Benelux) 2009 - University of Twente, Enschede, Netherlands
Duration: 9 Nov 200910 Nov 2009
Conference number: 4

Publication series

NameAnnual Symposium of the IEEE/EMBS Benelux Chapter
PublisherTwente University Press
Volume4th Annual Symposium of the IEEE/EMBS Benelux Chapter

Conference

Conference4th Annual Symposium of the Benelux Chapter of the IEEE Engineering in Medicine and Biology Society (IEEE-EMBS Benelux) 2009
CountryNetherlands
CityEnschede
Period9/11/0910/11/09

Keywords

  • METIS-268934
  • EWI-17373
  • BSS-Electrical Neurostimulation
  • IR-70364

Cite this

Lourens, M. A. J., Meijer, H. G. E., Heida, T., & van Gils, S. A. (2009). The pedunculopontine nucleus as alternative target for deep brain stimulation. In Proceedings of the 4th Annual symposium of the IEEE-EMBS Benelux Chapter (pp. 27). (Annual Symposium of the IEEE/EMBS Benelux Chapter; Vol. 4th Annual Symposium of the IEEE/EMBS Benelux Chapter). Enschede: Twente University Press (TUP).
Lourens, Marcel Antonius Johannes ; Meijer, Hil Gaétan Ellart ; Heida, Tjitske ; van Gils, Stephanus A. / The pedunculopontine nucleus as alternative target for deep brain stimulation. Proceedings of the 4th Annual symposium of the IEEE-EMBS Benelux Chapter. Enschede : Twente University Press (TUP), 2009. pp. 27 (Annual Symposium of the IEEE/EMBS Benelux Chapter).
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title = "The pedunculopontine nucleus as alternative target for deep brain stimulation",
abstract = "Parkinson’s disease (PD) is a neurodegenerative disease associated with motor and nonmotor symptoms. Deep brain stimulation (DBS) is a surgical treatment where an electrode is implanted in a certain area in the brain. In PD this is mostly done in the subthalamic nucleus (STN) or the globus pallidus interna (GPi). High frequency stimulation (~130 Hz) is often a successful treatment. The pedunculopontine nucleus (PPN) has recently been suggested as a new therapeutic target for DBS, particularly for patients with severe gait and postural impairment [2]. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in STN [2]. Despite real therapeutic successes, the fundamental physiological mechanisms underlying the effect of DBS are still not understood. To get a better understanding of PPN stimulation we construct a computational model for PPN Type I neurons.",
keywords = "METIS-268934, EWI-17373, BSS-Electrical Neurostimulation, IR-70364",
author = "Lourens, {Marcel Antonius Johannes} and Meijer, {Hil Ga{\'e}tan Ellart} and Tjitske Heida and {van Gils}, {Stephanus A.}",
year = "2009",
month = "11",
day = "24",
language = "Undefined",
isbn = "978-90-365-2933-4",
series = "Annual Symposium of the IEEE/EMBS Benelux Chapter",
publisher = "Twente University Press (TUP)",
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Lourens, MAJ, Meijer, HGE, Heida, T & van Gils, SA 2009, The pedunculopontine nucleus as alternative target for deep brain stimulation. in Proceedings of the 4th Annual symposium of the IEEE-EMBS Benelux Chapter. Annual Symposium of the IEEE/EMBS Benelux Chapter, vol. 4th Annual Symposium of the IEEE/EMBS Benelux Chapter, Twente University Press (TUP), Enschede, pp. 27, 4th Annual Symposium of the Benelux Chapter of the IEEE Engineering in Medicine and Biology Society (IEEE-EMBS Benelux) 2009, Enschede, Netherlands, 9/11/09.

The pedunculopontine nucleus as alternative target for deep brain stimulation. / Lourens, Marcel Antonius Johannes; Meijer, Hil Gaétan Ellart; Heida, Tjitske; van Gils, Stephanus A.

Proceedings of the 4th Annual symposium of the IEEE-EMBS Benelux Chapter. Enschede : Twente University Press (TUP), 2009. p. 27 (Annual Symposium of the IEEE/EMBS Benelux Chapter; Vol. 4th Annual Symposium of the IEEE/EMBS Benelux Chapter).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

TY - GEN

T1 - The pedunculopontine nucleus as alternative target for deep brain stimulation

AU - Lourens, Marcel Antonius Johannes

AU - Meijer, Hil Gaétan Ellart

AU - Heida, Tjitske

AU - van Gils, Stephanus A.

PY - 2009/11/24

Y1 - 2009/11/24

N2 - Parkinson’s disease (PD) is a neurodegenerative disease associated with motor and nonmotor symptoms. Deep brain stimulation (DBS) is a surgical treatment where an electrode is implanted in a certain area in the brain. In PD this is mostly done in the subthalamic nucleus (STN) or the globus pallidus interna (GPi). High frequency stimulation (~130 Hz) is often a successful treatment. The pedunculopontine nucleus (PPN) has recently been suggested as a new therapeutic target for DBS, particularly for patients with severe gait and postural impairment [2]. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in STN [2]. Despite real therapeutic successes, the fundamental physiological mechanisms underlying the effect of DBS are still not understood. To get a better understanding of PPN stimulation we construct a computational model for PPN Type I neurons.

AB - Parkinson’s disease (PD) is a neurodegenerative disease associated with motor and nonmotor symptoms. Deep brain stimulation (DBS) is a surgical treatment where an electrode is implanted in a certain area in the brain. In PD this is mostly done in the subthalamic nucleus (STN) or the globus pallidus interna (GPi). High frequency stimulation (~130 Hz) is often a successful treatment. The pedunculopontine nucleus (PPN) has recently been suggested as a new therapeutic target for DBS, particularly for patients with severe gait and postural impairment [2]. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in STN [2]. Despite real therapeutic successes, the fundamental physiological mechanisms underlying the effect of DBS are still not understood. To get a better understanding of PPN stimulation we construct a computational model for PPN Type I neurons.

KW - METIS-268934

KW - EWI-17373

KW - BSS-Electrical Neurostimulation

KW - IR-70364

M3 - Conference contribution

SN - 978-90-365-2933-4

T3 - Annual Symposium of the IEEE/EMBS Benelux Chapter

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BT - Proceedings of the 4th Annual symposium of the IEEE-EMBS Benelux Chapter

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Lourens MAJ, Meijer HGE, Heida T, van Gils SA. The pedunculopontine nucleus as alternative target for deep brain stimulation. In Proceedings of the 4th Annual symposium of the IEEE-EMBS Benelux Chapter. Enschede: Twente University Press (TUP). 2009. p. 27. (Annual Symposium of the IEEE/EMBS Benelux Chapter).