The pedunculopontine nucleus as alternative target for deep brain stimulation

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    Abstract

    Parkinson’s disease (PD) is a neurodegenerative disease associated with motor and nonmotor symptoms. Deep brain stimulation (DBS) is a surgical treatment where an electrode is implanted in a certain area in the brain. In PD this is mostly done in the subthalamic nucleus (STN) or the globus pallidus interna (GPi). High frequency stimulation (~130 Hz) is often a successful treatment. The pedunculopontine nucleus (PPN) has recently been suggested as a new therapeutic target for DBS, particularly for patients with severe gait and postural impairment [2]. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in STN [2]. Despite real therapeutic successes, the fundamental physiological mechanisms underlying the effect of DBS are still not understood. To get a better understanding of PPN stimulation we construct a computational model for PPN Type I neurons.
    Original languageUndefined
    Title of host publicationProceedings of the 4th Annual symposium of the IEEE-EMBS Benelux Chapter
    Place of PublicationEnschede
    PublisherTwente University Press (TUP)
    Pages27
    Number of pages1
    ISBN (Print)978-90-365-2933-4
    Publication statusPublished - 24 Nov 2009
    Event4th Annual Symposium of the Benelux Chapter of the IEEE Engineering in Medicine and Biology Society (IEEE-EMBS Benelux) 2009 - University of Twente, Enschede, Netherlands
    Duration: 9 Nov 200910 Nov 2009
    Conference number: 4

    Publication series

    NameAnnual Symposium of the IEEE/EMBS Benelux Chapter
    PublisherTwente University Press
    Volume4th Annual Symposium of the IEEE/EMBS Benelux Chapter

    Conference

    Conference4th Annual Symposium of the Benelux Chapter of the IEEE Engineering in Medicine and Biology Society (IEEE-EMBS Benelux) 2009
    CountryNetherlands
    CityEnschede
    Period9/11/0910/11/09

    Keywords

    • METIS-268934
    • EWI-17373
    • BSS-Electrical Neurostimulation
    • IR-70364

    Cite this

    Lourens, M. A. J., Meijer, H. G. E., Heida, T., & van Gils, S. A. (2009). The pedunculopontine nucleus as alternative target for deep brain stimulation. In Proceedings of the 4th Annual symposium of the IEEE-EMBS Benelux Chapter (pp. 27). (Annual Symposium of the IEEE/EMBS Benelux Chapter; Vol. 4th Annual Symposium of the IEEE/EMBS Benelux Chapter). Enschede: Twente University Press (TUP).