The pedunculopontine nucleus as alternative target for deep brain stimulation

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    Abstract

    Parkinson’s disease (PD) is a neurodegenerative disease associated with motor and nonmotor symptoms. Deep brain stimulation (DBS) is a surgical treatment where an electrode is implanted in a certain area in the brain. In PD this is mostly done in the subthalamic nucleus (STN) or the globus pallidus interna (GPi). High frequency stimulation (~130 Hz) is often a successful treatment. The pedunculopontine nucleus (PPN) has recently been suggested as a new therapeutic target for DBS, particularly for patients with severe gait and postural impairment [2]. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in STN [2]. Despite real therapeutic successes, the fundamental physiological mechanisms underlying the effect of DBS are still not understood. To get a better understanding of PPN stimulation we construct a computational model for PPN Type I neurons.
    Original languageUndefined
    Title of host publicationProceedings of the 4th Annual symposium of the IEEE-EMBS Benelux Chapter
    Place of PublicationEnschede
    PublisherTwente University Press (TUP)
    Pages27
    Number of pages1
    ISBN (Print)978-90-365-2933-4
    Publication statusPublished - 24 Nov 2009
    Event4th Annual Symposium of the Benelux Chapter of the IEEE Engineering in Medicine and Biology Society (IEEE-EMBS Benelux) 2009 - University of Twente, Enschede, Netherlands
    Duration: 9 Nov 200910 Nov 2009
    Conference number: 4

    Publication series

    NameAnnual Symposium of the IEEE/EMBS Benelux Chapter
    PublisherTwente University Press
    Volume4th Annual Symposium of the IEEE/EMBS Benelux Chapter

    Conference

    Conference4th Annual Symposium of the Benelux Chapter of the IEEE Engineering in Medicine and Biology Society (IEEE-EMBS Benelux) 2009
    CountryNetherlands
    CityEnschede
    Period9/11/0910/11/09

    Keywords

    • METIS-268934
    • EWI-17373
    • BSS-Electrical Neurostimulation
    • IR-70364

    Cite this

    Lourens, M. A. J., Meijer, H. G. E., Heida, T., & van Gils, S. A. (2009). The pedunculopontine nucleus as alternative target for deep brain stimulation. In Proceedings of the 4th Annual symposium of the IEEE-EMBS Benelux Chapter (pp. 27). (Annual Symposium of the IEEE/EMBS Benelux Chapter; Vol. 4th Annual Symposium of the IEEE/EMBS Benelux Chapter). Enschede: Twente University Press (TUP).
    Lourens, Marcel Antonius Johannes ; Meijer, Hil Gaétan Ellart ; Heida, Tjitske ; van Gils, Stephanus A. / The pedunculopontine nucleus as alternative target for deep brain stimulation. Proceedings of the 4th Annual symposium of the IEEE-EMBS Benelux Chapter. Enschede : Twente University Press (TUP), 2009. pp. 27 (Annual Symposium of the IEEE/EMBS Benelux Chapter).
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    title = "The pedunculopontine nucleus as alternative target for deep brain stimulation",
    abstract = "Parkinson’s disease (PD) is a neurodegenerative disease associated with motor and nonmotor symptoms. Deep brain stimulation (DBS) is a surgical treatment where an electrode is implanted in a certain area in the brain. In PD this is mostly done in the subthalamic nucleus (STN) or the globus pallidus interna (GPi). High frequency stimulation (~130 Hz) is often a successful treatment. The pedunculopontine nucleus (PPN) has recently been suggested as a new therapeutic target for DBS, particularly for patients with severe gait and postural impairment [2]. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in STN [2]. Despite real therapeutic successes, the fundamental physiological mechanisms underlying the effect of DBS are still not understood. To get a better understanding of PPN stimulation we construct a computational model for PPN Type I neurons.",
    keywords = "METIS-268934, EWI-17373, BSS-Electrical Neurostimulation, IR-70364",
    author = "Lourens, {Marcel Antonius Johannes} and Meijer, {Hil Ga{\'e}tan Ellart} and Tjitske Heida and {van Gils}, {Stephanus A.}",
    year = "2009",
    month = "11",
    day = "24",
    language = "Undefined",
    isbn = "978-90-365-2933-4",
    series = "Annual Symposium of the IEEE/EMBS Benelux Chapter",
    publisher = "Twente University Press (TUP)",
    pages = "27",
    booktitle = "Proceedings of the 4th Annual symposium of the IEEE-EMBS Benelux Chapter",
    address = "Netherlands",

    }

    Lourens, MAJ, Meijer, HGE, Heida, T & van Gils, SA 2009, The pedunculopontine nucleus as alternative target for deep brain stimulation. in Proceedings of the 4th Annual symposium of the IEEE-EMBS Benelux Chapter. Annual Symposium of the IEEE/EMBS Benelux Chapter, vol. 4th Annual Symposium of the IEEE/EMBS Benelux Chapter, Twente University Press (TUP), Enschede, pp. 27, 4th Annual Symposium of the Benelux Chapter of the IEEE Engineering in Medicine and Biology Society (IEEE-EMBS Benelux) 2009, Enschede, Netherlands, 9/11/09.

    The pedunculopontine nucleus as alternative target for deep brain stimulation. / Lourens, Marcel Antonius Johannes; Meijer, Hil Gaétan Ellart; Heida, Tjitske; van Gils, Stephanus A.

    Proceedings of the 4th Annual symposium of the IEEE-EMBS Benelux Chapter. Enschede : Twente University Press (TUP), 2009. p. 27 (Annual Symposium of the IEEE/EMBS Benelux Chapter; Vol. 4th Annual Symposium of the IEEE/EMBS Benelux Chapter).

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

    TY - GEN

    T1 - The pedunculopontine nucleus as alternative target for deep brain stimulation

    AU - Lourens, Marcel Antonius Johannes

    AU - Meijer, Hil Gaétan Ellart

    AU - Heida, Tjitske

    AU - van Gils, Stephanus A.

    PY - 2009/11/24

    Y1 - 2009/11/24

    N2 - Parkinson’s disease (PD) is a neurodegenerative disease associated with motor and nonmotor symptoms. Deep brain stimulation (DBS) is a surgical treatment where an electrode is implanted in a certain area in the brain. In PD this is mostly done in the subthalamic nucleus (STN) or the globus pallidus interna (GPi). High frequency stimulation (~130 Hz) is often a successful treatment. The pedunculopontine nucleus (PPN) has recently been suggested as a new therapeutic target for DBS, particularly for patients with severe gait and postural impairment [2]. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in STN [2]. Despite real therapeutic successes, the fundamental physiological mechanisms underlying the effect of DBS are still not understood. To get a better understanding of PPN stimulation we construct a computational model for PPN Type I neurons.

    AB - Parkinson’s disease (PD) is a neurodegenerative disease associated with motor and nonmotor symptoms. Deep brain stimulation (DBS) is a surgical treatment where an electrode is implanted in a certain area in the brain. In PD this is mostly done in the subthalamic nucleus (STN) or the globus pallidus interna (GPi). High frequency stimulation (~130 Hz) is often a successful treatment. The pedunculopontine nucleus (PPN) has recently been suggested as a new therapeutic target for DBS, particularly for patients with severe gait and postural impairment [2]. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in STN [2]. Despite real therapeutic successes, the fundamental physiological mechanisms underlying the effect of DBS are still not understood. To get a better understanding of PPN stimulation we construct a computational model for PPN Type I neurons.

    KW - METIS-268934

    KW - EWI-17373

    KW - BSS-Electrical Neurostimulation

    KW - IR-70364

    M3 - Conference contribution

    SN - 978-90-365-2933-4

    T3 - Annual Symposium of the IEEE/EMBS Benelux Chapter

    SP - 27

    BT - Proceedings of the 4th Annual symposium of the IEEE-EMBS Benelux Chapter

    PB - Twente University Press (TUP)

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    ER -

    Lourens MAJ, Meijer HGE, Heida T, van Gils SA. The pedunculopontine nucleus as alternative target for deep brain stimulation. In Proceedings of the 4th Annual symposium of the IEEE-EMBS Benelux Chapter. Enschede: Twente University Press (TUP). 2009. p. 27. (Annual Symposium of the IEEE/EMBS Benelux Chapter).