Abstract
Parkinson’s disease (PD) is a neurodegenerative disease associated with motor and nonmotor symptoms. Deep brain stimulation (DBS) is a surgical treatment where an electrode is implanted in a certain area in the brain. In PD this is mostly done in the subthalamic nucleus (STN) or the globus pallidus interna (GPi). High frequency stimulation (~130 Hz) is often a successful treatment.
The pedunculopontine nucleus (PPN) has recently been suggested as a new therapeutic target for DBS, particularly for patients with severe gait and postural impairment [2]. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in STN [2].
Despite real therapeutic successes, the fundamental physiological mechanisms underlying the effect of DBS are still not understood. To get a better understanding of PPN stimulation we construct a computational model for PPN Type I neurons.
Original language | Undefined |
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Title of host publication | Proceedings of the 4th Annual symposium of the IEEE-EMBS Benelux Chapter |
Place of Publication | Enschede |
Publisher | Twente University Press (TUP) |
Pages | 27 |
Number of pages | 1 |
ISBN (Print) | 978-90-365-2933-4 |
Publication status | Published - 24 Nov 2009 |
Event | 4th Annual Symposium of the Benelux Chapter of the IEEE Engineering in Medicine and Biology Society (IEEE-EMBS Benelux) 2009 - University of Twente, Enschede, Netherlands Duration: 9 Nov 2009 → 10 Nov 2009 Conference number: 4 |
Publication series
Name | Annual Symposium of the IEEE/EMBS Benelux Chapter |
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Publisher | Twente University Press |
Volume | 4th Annual Symposium of the IEEE/EMBS Benelux Chapter |
Conference
Conference | 4th Annual Symposium of the Benelux Chapter of the IEEE Engineering in Medicine and Biology Society (IEEE-EMBS Benelux) 2009 |
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Country/Territory | Netherlands |
City | Enschede |
Period | 9/11/09 → 10/11/09 |
Keywords
- METIS-268934
- EWI-17373
- BSS-Electrical Neurostimulation
- IR-70364