Parkinson’s disease (PD) is a neurodegenerative disease associated with motor and nonmotor symptoms. Deep brain stimulation (DBS) is a surgical treatment where an electrode is implanted in a certain area in the brain. In PD this is mostly done in the subthalamic nucleus (STN) or the globus pallidus interna (GPi). High frequency stimulation (~130 Hz) is often a successful treatment. The pedunculopontine nucleus (PPN) has recently been suggested as a new therapeutic target for DBS, particularly for patients with severe gait and postural impairment . Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in STN . Despite real therapeutic successes, the fundamental physiological mechanisms underlying the effect of DBS are still not understood. To get a better understanding of PPN stimulation we construct a computational model for PPN Type I neurons.
|Title of host publication||Proceedings of the 4th Annual symposium of the IEEE-EMBS Benelux Chapter|
|Place of Publication||Enschede|
|Publisher||Twente University Press (TUP)|
|Number of pages||1|
|Publication status||Published - 24 Nov 2009|
|Event||4th Annual Symposium of the Benelux Chapter of the IEEE Engineering in Medicine and Biology Society (IEEE-EMBS Benelux) 2009 - University of Twente, Enschede, Netherlands|
Duration: 9 Nov 2009 → 10 Nov 2009
Conference number: 4
|Name||Annual Symposium of the IEEE/EMBS Benelux Chapter|
|Publisher||Twente University Press|
|Volume||4th Annual Symposium of the IEEE/EMBS Benelux Chapter|
|Conference||4th Annual Symposium of the Benelux Chapter of the IEEE Engineering in Medicine and Biology Society (IEEE-EMBS Benelux) 2009|
|Period||9/11/09 → 10/11/09|
- BSS-Electrical Neurostimulation
Lourens, M. A. J., Meijer, H. G. E., Heida, T., & van Gils, S. A. (2009). The pedunculopontine nucleus as alternative target for deep brain stimulation. In Proceedings of the 4th Annual symposium of the IEEE-EMBS Benelux Chapter (pp. 27). (Annual Symposium of the IEEE/EMBS Benelux Chapter; Vol. 4th Annual Symposium of the IEEE/EMBS Benelux Chapter). Enschede: Twente University Press (TUP).