The preparation of monodisperse biodegradable polyester nanoparticles with a controlled size

M.L.T. Zweers, Dirk W. Grijpma, G.H.M. Engbers, Jan Feijen

Research output: Contribution to journalArticleAcademicpeer-review

92 Citations (Scopus)

Abstract

In local drug delivery, nanoparticles based on biodegradable polymers can function as vehicles with controlled drug-release properties. To achieve a well-controlled drug-release profile, control over the particle size is of great importance. Therefore, biodegradable polyester nanoparticles were prepared by the salting-out method. Process variables were varied to study the effect on the particle size. The monodisperse particles obtained were between 100 and 400 nm in size and spherical in shape. It was found that the particle size could be adjusted by varying the preparation conditions upon which the polymer concentration had the most pronounced effect.
Original languageUndefined
Pages (from-to)559-566
JournalJournal of biomedical materials research
Volume66B
Issue number2
DOIs
Publication statusPublished - 2003

Keywords

  • poly(lactic-co-glycolic acid)
  • Drug delivery
  • Salting out
  • Nanoparticles
  • IR-71910
  • METIS-216586

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