The preparation of monodisperse biodegradable polyester nanoparticles with a controlled size

M.L.T. Zweers, Dirk W. Grijpma, G.H.M. Engbers, Jan Feijen

Research output: Contribution to journalArticleAcademicpeer-review

79 Citations (Scopus)

Abstract

In local drug delivery, nanoparticles based on biodegradable polymers can function as vehicles with controlled drug-release properties. To achieve a well-controlled drug-release profile, control over the particle size is of great importance. Therefore, biodegradable polyester nanoparticles were prepared by the salting-out method. Process variables were varied to study the effect on the particle size. The monodisperse particles obtained were between 100 and 400 nm in size and spherical in shape. It was found that the particle size could be adjusted by varying the preparation conditions upon which the polymer concentration had the most pronounced effect.
Original languageUndefined
Pages (from-to)559-566
JournalJournal of biomedical materials research
Volume66B
Issue number2
DOIs
Publication statusPublished - 2003

Keywords

  • poly(lactic-co-glycolic acid)
  • Drug delivery
  • Salting out
  • Nanoparticles
  • IR-71910
  • METIS-216586

Cite this

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title = "The preparation of monodisperse biodegradable polyester nanoparticles with a controlled size",
abstract = "In local drug delivery, nanoparticles based on biodegradable polymers can function as vehicles with controlled drug-release properties. To achieve a well-controlled drug-release profile, control over the particle size is of great importance. Therefore, biodegradable polyester nanoparticles were prepared by the salting-out method. Process variables were varied to study the effect on the particle size. The monodisperse particles obtained were between 100 and 400 nm in size and spherical in shape. It was found that the particle size could be adjusted by varying the preparation conditions upon which the polymer concentration had the most pronounced effect.",
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The preparation of monodisperse biodegradable polyester nanoparticles with a controlled size. / Zweers, M.L.T.; Grijpma, Dirk W.; Engbers, G.H.M.; Feijen, Jan.

In: Journal of biomedical materials research, Vol. 66B, No. 2, 2003, p. 559-566.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - The preparation of monodisperse biodegradable polyester nanoparticles with a controlled size

AU - Zweers, M.L.T.

AU - Grijpma, Dirk W.

AU - Engbers, G.H.M.

AU - Feijen, Jan

PY - 2003

Y1 - 2003

N2 - In local drug delivery, nanoparticles based on biodegradable polymers can function as vehicles with controlled drug-release properties. To achieve a well-controlled drug-release profile, control over the particle size is of great importance. Therefore, biodegradable polyester nanoparticles were prepared by the salting-out method. Process variables were varied to study the effect on the particle size. The monodisperse particles obtained were between 100 and 400 nm in size and spherical in shape. It was found that the particle size could be adjusted by varying the preparation conditions upon which the polymer concentration had the most pronounced effect.

AB - In local drug delivery, nanoparticles based on biodegradable polymers can function as vehicles with controlled drug-release properties. To achieve a well-controlled drug-release profile, control over the particle size is of great importance. Therefore, biodegradable polyester nanoparticles were prepared by the salting-out method. Process variables were varied to study the effect on the particle size. The monodisperse particles obtained were between 100 and 400 nm in size and spherical in shape. It was found that the particle size could be adjusted by varying the preparation conditions upon which the polymer concentration had the most pronounced effect.

KW - poly(lactic-co-glycolic acid)

KW - Drug delivery

KW - Salting out

KW - Nanoparticles

KW - IR-71910

KW - METIS-216586

U2 - 10.1002/jbm.b.10046

DO - 10.1002/jbm.b.10046

M3 - Article

VL - 66B

SP - 559

EP - 566

JO - Journal of biomedical materials research

JF - Journal of biomedical materials research

SN - 0021-9304

IS - 2

ER -