The prognostic relevance of the mitotic activity index in axillary lymph node-negative breast cancer

Jan J. Jobsen*, Job van der Palen, Mariël Brinkhuis, Johan W.R. Nortier, Henk Struikmans

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

The aim of the present study is to look at the mitotic activity index (MAI) as a prognostic factor in a prospective population-based cohort of lymph node-negative invasive breast cancer patients. Analyses were based on 2,048 breast-conserving therapies in 1,971 patients, node-negative, and without any form of adjuvant systemic therapy with long-term follow-up. The 15-year distant metastases-free survival (DMFS) for women B55 years was 88.3 % for low MAI values (B12) versus 73.4 % for high MAI values ([12); (HR 2.8; 95 % CI 1.8–4.4; p\0.001). Multivariate analyses for DMFS showed significance for MAI. For MAI and Bloom–Richardson grading, by performing a likelihood ratio test, we showed the statistical significance for both. For women[55-years, the MAI was not an independent significant factor. We also confirmed the above findings for disease-specific survival. When multi-gene assays are not available, the MAI remains a robust prognostic marker in women younger than 55 years of age with early node-negative breast cancer.
Original languageEnglish
Pages (from-to)343-351
Number of pages9
JournalBreast cancer research and treatment
Volume149
Issue number2
Early online date21 Dec 2014
DOIs
Publication statusPublished - Jan 2015

Keywords

  • Mitotic activity index
  • Prognosis
  • Age
  • Breast cancer
  • n/a OA procedure

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