The relationship between aurothioglucose- and d-penicillamine-induced proteinuria

F. Speerstra; L.B.A. van de Putte; J.J. Rasker; P. Reekers; J.P. Vandenbroucke

doi:10.3109/03009748409111310

The relationship between aurothioglucose- and d-penicillamine-induced proteinuria

F. Speerstra^*, L.B.A. van de Putte, J.J. Rasker, P. Reekers, J.P. Vandenbroucke

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

Abstract

We studied patients with rheumatoid arthritis who have been treated with aurothioglucose (Au) and subsequently with D-penicillamine (DP), and who developed drug-induced proteinuria, over a 10-year period. Twelve patients developed Au-induced and 19 DP-induced proteinuria. Of the 12 patients with Au-induced proteinuria, only 2 (17% developed DP-induced proteinuria, indicating a slightly increased risk as compared with the overall incidence (9.3 % of this reaction in 168 DP-treated patients. In addition, only a minority (2 out of 19, 10.6% of patients with DP-induced proteinuria had previous Au-induced proteinuria. These data may indicate that different mechanisms are operative in Au and DP-induced proteinuria, as is also suggested by the finding that HLA-DR3 was present more frequently in the latter (50% than in the former (21 % A history of previous Au-induced proteinuria is insufficient reason to deny these patients the benefits of subsequent treatment with DP.

Original language	English
Pages (from-to)	363-368
Number of pages	6
Journal	Scandinavian journal of rheumatology
Volume	13
Issue number	4
DOIs	https://doi.org/10.3109/03009748409111310
Publication status	Published - 1 Jan 1984
Externally published	Yes

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title = "The relationship between aurothioglucose- and d-penicillamine-induced proteinuria",

abstract = "We studied patients with rheumatoid arthritis who have been treated with aurothioglucose (Au) and subsequently with D-penicillamine (DP), and who developed drug-induced proteinuria, over a 10-year period. Twelve patients developed Au-induced and 19 DP-induced proteinuria. Of the 12 patients with Au-induced proteinuria, only 2 (17% developed DP-induced proteinuria, indicating a slightly increased risk as compared with the overall incidence (9.3 % of this reaction in 168 DP-treated patients. In addition, only a minority (2 out of 19, 10.6% of patients with DP-induced proteinuria had previous Au-induced proteinuria. These data may indicate that different mechanisms are operative in Au and DP-induced proteinuria, as is also suggested by the finding that HLA-DR3 was present more frequently in the latter (50% than in the former (21 % A history of previous Au-induced proteinuria is insufficient reason to deny these patients the benefits of subsequent treatment with DP.",

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AU - Speerstra, F.

AU - van de Putte, L.B.A.

AU - Rasker, J.J.

AU - Reekers, P.

AU - Vandenbroucke, J.P.

PY - 1984/1/1

Y1 - 1984/1/1

N2 - We studied patients with rheumatoid arthritis who have been treated with aurothioglucose (Au) and subsequently with D-penicillamine (DP), and who developed drug-induced proteinuria, over a 10-year period. Twelve patients developed Au-induced and 19 DP-induced proteinuria. Of the 12 patients with Au-induced proteinuria, only 2 (17% developed DP-induced proteinuria, indicating a slightly increased risk as compared with the overall incidence (9.3 % of this reaction in 168 DP-treated patients. In addition, only a minority (2 out of 19, 10.6% of patients with DP-induced proteinuria had previous Au-induced proteinuria. These data may indicate that different mechanisms are operative in Au and DP-induced proteinuria, as is also suggested by the finding that HLA-DR3 was present more frequently in the latter (50% than in the former (21 % A history of previous Au-induced proteinuria is insufficient reason to deny these patients the benefits of subsequent treatment with DP.

AB - We studied patients with rheumatoid arthritis who have been treated with aurothioglucose (Au) and subsequently with D-penicillamine (DP), and who developed drug-induced proteinuria, over a 10-year period. Twelve patients developed Au-induced and 19 DP-induced proteinuria. Of the 12 patients with Au-induced proteinuria, only 2 (17% developed DP-induced proteinuria, indicating a slightly increased risk as compared with the overall incidence (9.3 % of this reaction in 168 DP-treated patients. In addition, only a minority (2 out of 19, 10.6% of patients with DP-induced proteinuria had previous Au-induced proteinuria. These data may indicate that different mechanisms are operative in Au and DP-induced proteinuria, as is also suggested by the finding that HLA-DR3 was present more frequently in the latter (50% than in the former (21 % A history of previous Au-induced proteinuria is insufficient reason to deny these patients the benefits of subsequent treatment with DP.

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ER -

The relationship between aurothioglucose- and d-penicillamine-induced proteinuria

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