The role of 18F-FDG-PET/CT in the management of patients with high-risk breast cancer: case series and guideline comparison

Ben Bulten; M.J. de Haas; H.J. Bloemendal; A.J. van Overbeeke; J.P. Esser; H.J. Baarslag; Lioe-Fee de Geus-Oei; J.M.H. de Klerk

doi:10.4236/ami.2014.43005

The role of 18F-FDG-PET/CT in the management of patients with high-risk breast cancer: case series and guideline comparison

Ben Bulten, M.J. de Haas, H.J. Bloemendal, A.J. van Overbeeke, J.P. Esser, H.J. Baarslag, Lioe-Fee de Geus-Oei, J.M.H. de Klerk

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Abstract

Objectives: In grade III-IV breast cancer, dissemination of disease needs to be assessed. Until now this was done by conventional imaging (liver ultrasonography, chest X-ray and bone scintigraphy), but evidence favoring the use of FDG-PET/CT is accumulating. Methods: Patients with high-risk breast cancer, who had received conventional imaging and FDG-PET/CT, were included. Patients were staged and assigned a treatment after 1) conventional imaging and 2) FDG-PET/CT, both by a multidisciplinary oncology team. Equivocal FDG-PET/CT findings were histologically confirmed. Results: 16 patients were included (mean age 59 years). TNM-stage changed in 5 patients (31%) after FDG-PET/CT. In 3 patients (19%) unknown distant metastases were detected by FDG-PET/CT. An adjustment of treatment took place in 4 patients (25%). Conclusions: Our case series emphasizes the role of FDG-PET/CT in the staging of high-risk breast carcinoma, especially in the assessment of distant metastases. We suggest replacing conventional imaging with FDG-PET/CT.

Original language	Undefined
Pages (from-to)	35-41
Journal	Advances in molecular imaging
Volume	4
Issue number	3
DOIs	https://doi.org/10.4236/ami.2014.43005
Publication status	Published - 2014

Keywords

IR-94983
METIS-306770

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10.4236/ami.2014.43005

The role of FDG-PETCT in the management of patients with high-risk breast cancer, Bulten, 2014

Cite this

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title = "The role of 18F-FDG-PET/CT in the management of patients with high-risk breast cancer: case series and guideline comparison",

abstract = "Objectives: In grade III-IV breast cancer, dissemination of disease needs to be assessed. Until now this was done by conventional imaging (liver ultrasonography, chest X-ray and bone scintigraphy), but evidence favoring the use of FDG-PET/CT is accumulating. Methods: Patients with high-risk breast cancer, who had received conventional imaging and FDG-PET/CT, were included. Patients were staged and assigned a treatment after 1) conventional imaging and 2) FDG-PET/CT, both by a multidisciplinary oncology team. Equivocal FDG-PET/CT findings were histologically confirmed. Results: 16 patients were included (mean age 59 years). TNM-stage changed in 5 patients (31%) after FDG-PET/CT. In 3 patients (19%) unknown distant metastases were detected by FDG-PET/CT. An adjustment of treatment took place in 4 patients (25%). Conclusions: Our case series emphasizes the role of FDG-PET/CT in the staging of high-risk breast carcinoma, especially in the assessment of distant metastases. We suggest replacing conventional imaging with FDG-PET/CT.",

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T1 - The role of 18F-FDG-PET/CT in the management of patients with high-risk breast cancer: case series and guideline comparison

AU - Bulten, Ben

AU - de Haas, M.J.

AU - Bloemendal, H.J.

AU - van Overbeeke, A.J.

AU - Esser, J.P.

AU - Baarslag, H.J.

AU - de Geus-Oei, Lioe-Fee

AU - de Klerk, J.M.H.

N1 - Open access

PY - 2014

Y1 - 2014

N2 - Objectives: In grade III-IV breast cancer, dissemination of disease needs to be assessed. Until now this was done by conventional imaging (liver ultrasonography, chest X-ray and bone scintigraphy), but evidence favoring the use of FDG-PET/CT is accumulating. Methods: Patients with high-risk breast cancer, who had received conventional imaging and FDG-PET/CT, were included. Patients were staged and assigned a treatment after 1) conventional imaging and 2) FDG-PET/CT, both by a multidisciplinary oncology team. Equivocal FDG-PET/CT findings were histologically confirmed. Results: 16 patients were included (mean age 59 years). TNM-stage changed in 5 patients (31%) after FDG-PET/CT. In 3 patients (19%) unknown distant metastases were detected by FDG-PET/CT. An adjustment of treatment took place in 4 patients (25%). Conclusions: Our case series emphasizes the role of FDG-PET/CT in the staging of high-risk breast carcinoma, especially in the assessment of distant metastases. We suggest replacing conventional imaging with FDG-PET/CT.

AB - Objectives: In grade III-IV breast cancer, dissemination of disease needs to be assessed. Until now this was done by conventional imaging (liver ultrasonography, chest X-ray and bone scintigraphy), but evidence favoring the use of FDG-PET/CT is accumulating. Methods: Patients with high-risk breast cancer, who had received conventional imaging and FDG-PET/CT, were included. Patients were staged and assigned a treatment after 1) conventional imaging and 2) FDG-PET/CT, both by a multidisciplinary oncology team. Equivocal FDG-PET/CT findings were histologically confirmed. Results: 16 patients were included (mean age 59 years). TNM-stage changed in 5 patients (31%) after FDG-PET/CT. In 3 patients (19%) unknown distant metastases were detected by FDG-PET/CT. An adjustment of treatment took place in 4 patients (25%). Conclusions: Our case series emphasizes the role of FDG-PET/CT in the staging of high-risk breast carcinoma, especially in the assessment of distant metastases. We suggest replacing conventional imaging with FDG-PET/CT.

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