The Role of Fibroblast Activation Protein Inhibitor Positron Emission Tomography in Inflammatory and Infectious Diseases: An Updated Systematic Review

Domenico Albano; Alessio Rizzo; Riemer H.J.A. Slart; Søren Hess; Edel Noriega-Álvarez; Cristina Gamila Wakfie-Corieh; Lucia Leccisotti; Andor W.J.M. Glaudemans; Olivier Gheysens; Giorgio Treglia

doi:10.3390/ph17060716

The Role of Fibroblast Activation Protein Inhibitor Positron Emission Tomography in Inflammatory and Infectious Diseases: An Updated Systematic Review

Domenico Albano
, Alessio Rizzo
, Riemer H.J.A. Slart
, Søren Hess
, Edel Noriega-Álvarez
, Cristina Gamila Wakfie-Corieh
, Lucia Leccisotti
, Andor W.J.M. Glaudemans
, Olivier Gheysens
, Giorgio Treglia^*

^*Corresponding author for this work

Biomedical Photonic Imaging

Research output: Contribution to journal › Review article › Academic › peer-review

21 Citations (Scopus)

28 Downloads (Pure)

Abstract

The role of fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography (PET/CT) is emerging for the assessment of non-oncological diseases, such as inflammatory and infectious diseases, even if the evidence in the literature is still in its initial phases. We conducted a systematic search of Scopus, PubMed/MEDLINE, Embase, and Cochrane library databases for studies published before 31 December 2023 reporting infectious and inflammatory disease imaging with FAPI PET/CT. We included twenty-one studies for a total of 1046 patients. The most frequent disease studied was lung interstitial disease, investigated in six studies for a total of 200 patients, followed by bone and joint diseases in two studies and 185 patients, IgG4-related disease in 53 patients, and Crohn’s disease in 30 patients. Despite the heterogeneity of studies in terms of study design and technical features, FAPI PET/CT showed a high detection rate and diagnostic role. Moreover, when compared with 2-[¹⁸F]FDG PET/CT (n = 7 studies), FAPI PET/CT seems to have better diagnostic performances. The presence of chronic inflammation and tissue remodeling, typical of immune-mediated inflammatory conditions, may be the underlying mechanism of FAPI uptake.

Original language	English
Article number	716
Journal	Pharmaceuticals
Volume	17
Issue number	6
DOIs	https://doi.org/10.3390/ph17060716
Publication status	Published - Jun 2024

Keywords

FAPI
hybrid imaging
infection
inflammation
nuclear medicine
PET

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Albano, D., Rizzo, A., Slart, R. H. J. A., Hess, S., Noriega-Álvarez, E., Wakfie-Corieh, C. G., Leccisotti, L., Glaudemans, A. W. J. M., Gheysens, O., & Treglia, G. (2024). The Role of Fibroblast Activation Protein Inhibitor Positron Emission Tomography in Inflammatory and Infectious Diseases: An Updated Systematic Review. Pharmaceuticals, 17(6), Article 716. https://doi.org/10.3390/ph17060716

@article{a87ebeca4e2c4cc68231bffc5e4505d1,

title = "The Role of Fibroblast Activation Protein Inhibitor Positron Emission Tomography in Inflammatory and Infectious Diseases: An Updated Systematic Review",

abstract = "The role of fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography (PET/CT) is emerging for the assessment of non-oncological diseases, such as inflammatory and infectious diseases, even if the evidence in the literature is still in its initial phases. We conducted a systematic search of Scopus, PubMed/MEDLINE, Embase, and Cochrane library databases for studies published before 31 December 2023 reporting infectious and inflammatory disease imaging with FAPI PET/CT. We included twenty-one studies for a total of 1046 patients. The most frequent disease studied was lung interstitial disease, investigated in six studies for a total of 200 patients, followed by bone and joint diseases in two studies and 185 patients, IgG4-related disease in 53 patients, and Crohn{\textquoteright}s disease in 30 patients. Despite the heterogeneity of studies in terms of study design and technical features, FAPI PET/CT showed a high detection rate and diagnostic role. Moreover, when compared with 2-[18F]FDG PET/CT (n = 7 studies), FAPI PET/CT seems to have better diagnostic performances. The presence of chronic inflammation and tissue remodeling, typical of immune-mediated inflammatory conditions, may be the underlying mechanism of FAPI uptake.",

keywords = "FAPI, hybrid imaging, infection, inflammation, nuclear medicine, PET",

author = "Domenico Albano and Alessio Rizzo and Slart, \{Riemer H.J.A.\} and S{\o}ren Hess and Edel Noriega-{\'A}lvarez and Wakfie-Corieh, \{Cristina Gamila\} and Lucia Leccisotti and Glaudemans, \{Andor W.J.M.\} and Olivier Gheysens and Giorgio Treglia",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

month = jun,

doi = "10.3390/ph17060716",

language = "English",

volume = "17",

journal = "Pharmaceuticals",

issn = "1424-8247",

publisher = "MDPI",

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Albano, D, Rizzo, A, Slart, RHJA, Hess, S, Noriega-Álvarez, E, Wakfie-Corieh, CG, Leccisotti, L, Glaudemans, AWJM, Gheysens, O & Treglia, G 2024, 'The Role of Fibroblast Activation Protein Inhibitor Positron Emission Tomography in Inflammatory and Infectious Diseases: An Updated Systematic Review', Pharmaceuticals, vol. 17, no. 6, 716. https://doi.org/10.3390/ph17060716

TY - JOUR

T1 - The Role of Fibroblast Activation Protein Inhibitor Positron Emission Tomography in Inflammatory and Infectious Diseases

T2 - An Updated Systematic Review

AU - Albano, Domenico

AU - Rizzo, Alessio

AU - Slart, Riemer H.J.A.

AU - Hess, Søren

AU - Noriega-Álvarez, Edel

AU - Wakfie-Corieh, Cristina Gamila

AU - Leccisotti, Lucia

AU - Glaudemans, Andor W.J.M.

AU - Gheysens, Olivier

AU - Treglia, Giorgio

PY - 2024/6

Y1 - 2024/6

N2 - The role of fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography (PET/CT) is emerging for the assessment of non-oncological diseases, such as inflammatory and infectious diseases, even if the evidence in the literature is still in its initial phases. We conducted a systematic search of Scopus, PubMed/MEDLINE, Embase, and Cochrane library databases for studies published before 31 December 2023 reporting infectious and inflammatory disease imaging with FAPI PET/CT. We included twenty-one studies for a total of 1046 patients. The most frequent disease studied was lung interstitial disease, investigated in six studies for a total of 200 patients, followed by bone and joint diseases in two studies and 185 patients, IgG4-related disease in 53 patients, and Crohn’s disease in 30 patients. Despite the heterogeneity of studies in terms of study design and technical features, FAPI PET/CT showed a high detection rate and diagnostic role. Moreover, when compared with 2-[18F]FDG PET/CT (n = 7 studies), FAPI PET/CT seems to have better diagnostic performances. The presence of chronic inflammation and tissue remodeling, typical of immune-mediated inflammatory conditions, may be the underlying mechanism of FAPI uptake.

AB - The role of fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography (PET/CT) is emerging for the assessment of non-oncological diseases, such as inflammatory and infectious diseases, even if the evidence in the literature is still in its initial phases. We conducted a systematic search of Scopus, PubMed/MEDLINE, Embase, and Cochrane library databases for studies published before 31 December 2023 reporting infectious and inflammatory disease imaging with FAPI PET/CT. We included twenty-one studies for a total of 1046 patients. The most frequent disease studied was lung interstitial disease, investigated in six studies for a total of 200 patients, followed by bone and joint diseases in two studies and 185 patients, IgG4-related disease in 53 patients, and Crohn’s disease in 30 patients. Despite the heterogeneity of studies in terms of study design and technical features, FAPI PET/CT showed a high detection rate and diagnostic role. Moreover, when compared with 2-[18F]FDG PET/CT (n = 7 studies), FAPI PET/CT seems to have better diagnostic performances. The presence of chronic inflammation and tissue remodeling, typical of immune-mediated inflammatory conditions, may be the underlying mechanism of FAPI uptake.

KW - FAPI

KW - hybrid imaging

KW - infection

KW - inflammation

KW - nuclear medicine

KW - PET

UR - https://www.scopus.com/pages/publications/85197121695

U2 - 10.3390/ph17060716

DO - 10.3390/ph17060716

M3 - Review article

AN - SCOPUS:85197121695

SN - 1424-8247

VL - 17

JO - Pharmaceuticals

JF - Pharmaceuticals

IS - 6

M1 - 716

ER -

The Role of Fibroblast Activation Protein Inhibitor Positron Emission Tomography in Inflammatory and Infectious Diseases: An Updated Systematic Review

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