The spatial relation between early and delayed responses evoked by single pulse electrical stimulation in pre-surgical evaluation of epilepsy patients

D. van Blooijs, G. Huiskamp, Gerrit Jan Hebbink, M. van 't Klooster, Hil Gaétan Ellart Meijer, Stephanus A. van Gils, P. Gosselaar, F. Leijten

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

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    Abstract

    Purpose: Single pulse electrical stimulation (SPES) assists delineating epileptogenic tissue during long-term intracranial monitoring for pre-surgical evaluation. The SPES protocol consists of systematic stimulation of neighboring electrode pairs and analysis of responses in all other electrodes. SPES evokes early (ER) and delayed (DR) responses. DRs occur in epileptogenic tissue, but are stochastic: 10 stimuli are needed to reliably establish a response. ERs occur in healthy and diseased tissue and require only a single stimulus. We studied the spatial relation between ERs and DRs. If it is possible to predict DRs from ERs, this might improve the efficiency of SPES. Method: Data of one patient with TLE recorded in 84 grid electrodes were used. We counted per electrode the number of stimulus pairs that evoked ERs (eER) and per stimulus pair the number of ERs that were evoked (sER). Similarly, for DRs, eDR and sDR were determined. Also, per electrode we counted the number of stimulus pairs that evoked both ERs and DRs, eERDR and vice versa for sERDR. We selected electrodes with eER or sER >median as eER50 or sER50. We tested whether values for eDR and sDR were significantly more in the eER50 and sER50 groups. Finally we tested whether the ratios eERDR/eDR and sERDR/sDR differed significantly from 0.5. Results: eER values ranged from 0 to 41, median=8; sER:3-27, median= 17; eDR:0-28, median=17 and sDR:0-26,median=9. eDR and sDR values were higher in eER50 (p < 0.001) and sER50 (p = 0.1) electrodes. The ratios of eERDR/eDR and sERDR/sDR ranged from 0 to 1, median=0.24 and 0–0.64, median=0.25 respectively, with the average significantly lower than 0.5 (p < 0.001). Conclusion: The correlation between eER50 electrodes and high values of eDR indicates that ERs and DRs seem to occur within the same network. The low ratio eERDR/eDR suggests that ERs and DRs are not directly related. We will analyze more patients to confirm these findings.
    Original languageUndefined
    Title of host publication31st International Epilepsy Congress Istanbul, Turkey 5th–9th September, 2015
    Place of PublicationSt. Malden
    PublisherWiley Periodicals, Inc
    Pages148-148
    Number of pages1
    DOIs
    Publication statusPublished - 5 Sep 2015

    Publication series

    NameEpilepsia
    PublisherWiley Periodicals, Inc
    NumberSupplement S1: Special Issue
    Volume56
    ISSN (Print)0013-9580
    ISSN (Electronic)1528-1167

    Keywords

    • EWI-26952
    • Evoked Potential
    • IR-100243
    • Single Pulse Electrical Stimulation
    • METIS-316897
    • Epilepsy

    Cite this

    van Blooijs, D., Huiskamp, G., Hebbink, G. J., van 't Klooster, M., Meijer, H. G. E., van Gils, S. A., ... Leijten, F. (2015). The spatial relation between early and delayed responses evoked by single pulse electrical stimulation in pre-surgical evaluation of epilepsy patients. In 31st International Epilepsy Congress Istanbul, Turkey 5th–9th September, 2015 (pp. 148-148). (Epilepsia; Vol. 56, No. Supplement S1: Special Issue). St. Malden: Wiley Periodicals, Inc. https://doi.org/10.1111/epi.13241
    van Blooijs, D. ; Huiskamp, G. ; Hebbink, Gerrit Jan ; van 't Klooster, M. ; Meijer, Hil Gaétan Ellart ; van Gils, Stephanus A. ; Gosselaar, P. ; Leijten, F. / The spatial relation between early and delayed responses evoked by single pulse electrical stimulation in pre-surgical evaluation of epilepsy patients. 31st International Epilepsy Congress Istanbul, Turkey 5th–9th September, 2015. St. Malden : Wiley Periodicals, Inc, 2015. pp. 148-148 (Epilepsia; Supplement S1: Special Issue).
    @inproceedings{4c8faacea0be45d5928c37af3630d637,
    title = "The spatial relation between early and delayed responses evoked by single pulse electrical stimulation in pre-surgical evaluation of epilepsy patients",
    abstract = "Purpose: Single pulse electrical stimulation (SPES) assists delineating epileptogenic tissue during long-term intracranial monitoring for pre-surgical evaluation. The SPES protocol consists of systematic stimulation of neighboring electrode pairs and analysis of responses in all other electrodes. SPES evokes early (ER) and delayed (DR) responses. DRs occur in epileptogenic tissue, but are stochastic: 10 stimuli are needed to reliably establish a response. ERs occur in healthy and diseased tissue and require only a single stimulus. We studied the spatial relation between ERs and DRs. If it is possible to predict DRs from ERs, this might improve the efficiency of SPES. Method: Data of one patient with TLE recorded in 84 grid electrodes were used. We counted per electrode the number of stimulus pairs that evoked ERs (eER) and per stimulus pair the number of ERs that were evoked (sER). Similarly, for DRs, eDR and sDR were determined. Also, per electrode we counted the number of stimulus pairs that evoked both ERs and DRs, eERDR and vice versa for sERDR. We selected electrodes with eER or sER >median as eER50 or sER50. We tested whether values for eDR and sDR were significantly more in the eER50 and sER50 groups. Finally we tested whether the ratios eERDR/eDR and sERDR/sDR differed significantly from 0.5. Results: eER values ranged from 0 to 41, median=8; sER:3-27, median= 17; eDR:0-28, median=17 and sDR:0-26,median=9. eDR and sDR values were higher in eER50 (p < 0.001) and sER50 (p = 0.1) electrodes. The ratios of eERDR/eDR and sERDR/sDR ranged from 0 to 1, median=0.24 and 0–0.64, median=0.25 respectively, with the average significantly lower than 0.5 (p < 0.001). Conclusion: The correlation between eER50 electrodes and high values of eDR indicates that ERs and DRs seem to occur within the same network. The low ratio eERDR/eDR suggests that ERs and DRs are not directly related. We will analyze more patients to confirm these findings.",
    keywords = "EWI-26952, Evoked Potential, IR-100243, Single Pulse Electrical Stimulation, METIS-316897, Epilepsy",
    author = "{van Blooijs}, D. and G. Huiskamp and Hebbink, {Gerrit Jan} and {van 't Klooster}, M. and Meijer, {Hil Ga{\'e}tan Ellart} and {van Gils}, {Stephanus A.} and P. Gosselaar and F. Leijten",
    note = "Special Issue: 31 International Epilepsy Congress Istanbul, Turkey 5–9 September, 2015",
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    month = "9",
    day = "5",
    doi = "10.1111/epi.13241",
    language = "Undefined",
    series = "Epilepsia",
    publisher = "Wiley Periodicals, Inc",
    number = "Supplement S1: Special Issue",
    pages = "148--148",
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    van Blooijs, D, Huiskamp, G, Hebbink, GJ, van 't Klooster, M, Meijer, HGE, van Gils, SA, Gosselaar, P & Leijten, F 2015, The spatial relation between early and delayed responses evoked by single pulse electrical stimulation in pre-surgical evaluation of epilepsy patients. in 31st International Epilepsy Congress Istanbul, Turkey 5th–9th September, 2015. Epilepsia, no. Supplement S1: Special Issue, vol. 56, Wiley Periodicals, Inc, St. Malden, pp. 148-148. https://doi.org/10.1111/epi.13241

    The spatial relation between early and delayed responses evoked by single pulse electrical stimulation in pre-surgical evaluation of epilepsy patients. / van Blooijs, D.; Huiskamp, G.; Hebbink, Gerrit Jan; van 't Klooster, M.; Meijer, Hil Gaétan Ellart; van Gils, Stephanus A.; Gosselaar, P.; Leijten, F.

    31st International Epilepsy Congress Istanbul, Turkey 5th–9th September, 2015. St. Malden : Wiley Periodicals, Inc, 2015. p. 148-148 (Epilepsia; Vol. 56, No. Supplement S1: Special Issue).

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

    TY - GEN

    T1 - The spatial relation between early and delayed responses evoked by single pulse electrical stimulation in pre-surgical evaluation of epilepsy patients

    AU - van Blooijs, D.

    AU - Huiskamp, G.

    AU - Hebbink, Gerrit Jan

    AU - van 't Klooster, M.

    AU - Meijer, Hil Gaétan Ellart

    AU - van Gils, Stephanus A.

    AU - Gosselaar, P.

    AU - Leijten, F.

    N1 - Special Issue: 31 International Epilepsy Congress Istanbul, Turkey 5–9 September, 2015

    PY - 2015/9/5

    Y1 - 2015/9/5

    N2 - Purpose: Single pulse electrical stimulation (SPES) assists delineating epileptogenic tissue during long-term intracranial monitoring for pre-surgical evaluation. The SPES protocol consists of systematic stimulation of neighboring electrode pairs and analysis of responses in all other electrodes. SPES evokes early (ER) and delayed (DR) responses. DRs occur in epileptogenic tissue, but are stochastic: 10 stimuli are needed to reliably establish a response. ERs occur in healthy and diseased tissue and require only a single stimulus. We studied the spatial relation between ERs and DRs. If it is possible to predict DRs from ERs, this might improve the efficiency of SPES. Method: Data of one patient with TLE recorded in 84 grid electrodes were used. We counted per electrode the number of stimulus pairs that evoked ERs (eER) and per stimulus pair the number of ERs that were evoked (sER). Similarly, for DRs, eDR and sDR were determined. Also, per electrode we counted the number of stimulus pairs that evoked both ERs and DRs, eERDR and vice versa for sERDR. We selected electrodes with eER or sER >median as eER50 or sER50. We tested whether values for eDR and sDR were significantly more in the eER50 and sER50 groups. Finally we tested whether the ratios eERDR/eDR and sERDR/sDR differed significantly from 0.5. Results: eER values ranged from 0 to 41, median=8; sER:3-27, median= 17; eDR:0-28, median=17 and sDR:0-26,median=9. eDR and sDR values were higher in eER50 (p < 0.001) and sER50 (p = 0.1) electrodes. The ratios of eERDR/eDR and sERDR/sDR ranged from 0 to 1, median=0.24 and 0–0.64, median=0.25 respectively, with the average significantly lower than 0.5 (p < 0.001). Conclusion: The correlation between eER50 electrodes and high values of eDR indicates that ERs and DRs seem to occur within the same network. The low ratio eERDR/eDR suggests that ERs and DRs are not directly related. We will analyze more patients to confirm these findings.

    AB - Purpose: Single pulse electrical stimulation (SPES) assists delineating epileptogenic tissue during long-term intracranial monitoring for pre-surgical evaluation. The SPES protocol consists of systematic stimulation of neighboring electrode pairs and analysis of responses in all other electrodes. SPES evokes early (ER) and delayed (DR) responses. DRs occur in epileptogenic tissue, but are stochastic: 10 stimuli are needed to reliably establish a response. ERs occur in healthy and diseased tissue and require only a single stimulus. We studied the spatial relation between ERs and DRs. If it is possible to predict DRs from ERs, this might improve the efficiency of SPES. Method: Data of one patient with TLE recorded in 84 grid electrodes were used. We counted per electrode the number of stimulus pairs that evoked ERs (eER) and per stimulus pair the number of ERs that were evoked (sER). Similarly, for DRs, eDR and sDR were determined. Also, per electrode we counted the number of stimulus pairs that evoked both ERs and DRs, eERDR and vice versa for sERDR. We selected electrodes with eER or sER >median as eER50 or sER50. We tested whether values for eDR and sDR were significantly more in the eER50 and sER50 groups. Finally we tested whether the ratios eERDR/eDR and sERDR/sDR differed significantly from 0.5. Results: eER values ranged from 0 to 41, median=8; sER:3-27, median= 17; eDR:0-28, median=17 and sDR:0-26,median=9. eDR and sDR values were higher in eER50 (p < 0.001) and sER50 (p = 0.1) electrodes. The ratios of eERDR/eDR and sERDR/sDR ranged from 0 to 1, median=0.24 and 0–0.64, median=0.25 respectively, with the average significantly lower than 0.5 (p < 0.001). Conclusion: The correlation between eER50 electrodes and high values of eDR indicates that ERs and DRs seem to occur within the same network. The low ratio eERDR/eDR suggests that ERs and DRs are not directly related. We will analyze more patients to confirm these findings.

    KW - EWI-26952

    KW - Evoked Potential

    KW - IR-100243

    KW - Single Pulse Electrical Stimulation

    KW - METIS-316897

    KW - Epilepsy

    U2 - 10.1111/epi.13241

    DO - 10.1111/epi.13241

    M3 - Conference contribution

    T3 - Epilepsia

    SP - 148

    EP - 148

    BT - 31st International Epilepsy Congress Istanbul, Turkey 5th–9th September, 2015

    PB - Wiley Periodicals, Inc

    CY - St. Malden

    ER -

    van Blooijs D, Huiskamp G, Hebbink GJ, van 't Klooster M, Meijer HGE, van Gils SA et al. The spatial relation between early and delayed responses evoked by single pulse electrical stimulation in pre-surgical evaluation of epilepsy patients. In 31st International Epilepsy Congress Istanbul, Turkey 5th–9th September, 2015. St. Malden: Wiley Periodicals, Inc. 2015. p. 148-148. (Epilepsia; Supplement S1: Special Issue). https://doi.org/10.1111/epi.13241