The Stress of Measuring Plantar Tissue Stress in People with Diabetes-Related Foot Ulcers: Biomechanical and Feasibility Findings from Two Prospective Cohort Studies

Chantal M. Hulshof*, Madelyn Page, Sjef G. van Baal, Sicco A. Bus, Malindu E. Fernando, Lisette van Gemert-Pijnen, Kilian D.R. Kappert, Scott Lucadou-Wells, Bijan Najafi, Jaap J. van Netten*, Peter A. Lazzarini

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Reducing high mechanical stress is imperative to heal diabetes-related foot ulcers. We explored the association of cumulative plantar tissue stress (CPTS) and plantar foot ulcer healing, and the feasibility of measuring CPTS, in two prospective cohort studies (Australia (AU) and The Netherlands (NL)). Both studies used multiple sensors to measure factors to determine CPTS: plantar pressures, weight-bearing activities, and adherence to offloading treatments, with thermal stress response also measured to estimate shear stress in the AU-study. The primary outcome was ulcer healing at 12 weeks. Twenty-five participants were recruited: 13 in the AU-study and 12 in the NL-study. CPTS data were complete for five participants (38%) at baseline and one (8%) during follow-up in the AU-study, and one (8%) at baseline and zero (0%) during follow-up in the NL-study. Reasons for low completion at baseline were technical issues (AU-study: 31%, NL-study: 50%), non-adherent participants (15% and 8%) or combinations (15% and 33%); and at follow-up refusal of participants (62% and 25%). These underpowered findings showed that CPTS was non-significantly lower in people who healed compared with non-healed people (457 [117; 727], 679 [312; 1327] MPa·s/day). Current feasibility of CPTS seems low, given technical challenges and non-adherence, which may reflect the burden of treating diabetes-related foot ulcers.

Original languageEnglish
Article number2411
JournalSensors
Volume24
Issue number8
DOIs
Publication statusPublished - 10 Apr 2024

Keywords

  • adherence
  • daily-life activity
  • diabetic foot
  • foot ulcer
  • offloading
  • plantar pressure
  • shear stress

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