The subthalamic nucleus, part II

Tjitske Heida, Enrico Marani, Kamen G. Usunoff

Research output: Book/ReportBookAcademic

12 Citations (Scopus)
24 Downloads (Pure)

Abstract

Part II starts with a systemic model of the basal ganglia to evaluate the position of the STN in the direct, indirect and hyperdirect pathways. A summary of in vitro studies is given, describing STN spontaneous activity as well as responses to depolarizing and hyperpolarizing inputs, and high frequency stimulation. STN bursting activity and the underlying ionic mechanisms are investigated. Deep brain stimulation used for symptomatic treatment of Parkinson's disease is discussed in terms of the elements that are influenced and its hypothesized mechanisms. This part of the monograph pays attention to the pedunculopontine-subthalamic connections and tries in cell cultures to mimic neurotransmitter actions of the pedunculopontine nucleus and high frequency stiulation on cultured dissociated rat subthalamic neurons. STN cell models: single and multi compartment, and system level models are discussed in relation to subthalamic function and dysfunction. Part I and II are mutually compared.
Original languageUndefined
Place of PublicationLondon
PublisherSpringer
Number of pages88
ISBN (Print)978-3-540-79461-5
DOIs
Publication statusPublished - 23 Jul 2008

Publication series

NameAdvances in Anatomy, Embryology and Cell Biology
PublisherSpringer
No.DTR08-9/part II
Volumepart I

Keywords

  • EWI-13234
  • METIS-251131
  • BSS-Neurotechnology and cellular engineering
  • IR-64920

Cite this

Heida, T., Marani, E., & Usunoff, K. G. (2008). The subthalamic nucleus, part II. (Advances in Anatomy, Embryology and Cell Biology; Vol. part I, No. DTR08-9/part II). London: Springer. https://doi.org/10.1007/978-3-540-79462-2
Heida, Tjitske ; Marani, Enrico ; Usunoff, Kamen G. / The subthalamic nucleus, part II. London : Springer, 2008. 88 p. (Advances in Anatomy, Embryology and Cell Biology; DTR08-9/part II).
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Heida, T, Marani, E & Usunoff, KG 2008, The subthalamic nucleus, part II. Advances in Anatomy, Embryology and Cell Biology, no. DTR08-9/part II, vol. part I, Springer, London. https://doi.org/10.1007/978-3-540-79462-2

The subthalamic nucleus, part II. / Heida, Tjitske; Marani, Enrico; Usunoff, Kamen G.

London : Springer, 2008. 88 p. (Advances in Anatomy, Embryology and Cell Biology; Vol. part I, No. DTR08-9/part II).

Research output: Book/ReportBookAcademic

TY - BOOK

T1 - The subthalamic nucleus, part II

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N2 - Part II starts with a systemic model of the basal ganglia to evaluate the position of the STN in the direct, indirect and hyperdirect pathways. A summary of in vitro studies is given, describing STN spontaneous activity as well as responses to depolarizing and hyperpolarizing inputs, and high frequency stimulation. STN bursting activity and the underlying ionic mechanisms are investigated. Deep brain stimulation used for symptomatic treatment of Parkinson's disease is discussed in terms of the elements that are influenced and its hypothesized mechanisms. This part of the monograph pays attention to the pedunculopontine-subthalamic connections and tries in cell cultures to mimic neurotransmitter actions of the pedunculopontine nucleus and high frequency stiulation on cultured dissociated rat subthalamic neurons. STN cell models: single and multi compartment, and system level models are discussed in relation to subthalamic function and dysfunction. Part I and II are mutually compared.

AB - Part II starts with a systemic model of the basal ganglia to evaluate the position of the STN in the direct, indirect and hyperdirect pathways. A summary of in vitro studies is given, describing STN spontaneous activity as well as responses to depolarizing and hyperpolarizing inputs, and high frequency stimulation. STN bursting activity and the underlying ionic mechanisms are investigated. Deep brain stimulation used for symptomatic treatment of Parkinson's disease is discussed in terms of the elements that are influenced and its hypothesized mechanisms. This part of the monograph pays attention to the pedunculopontine-subthalamic connections and tries in cell cultures to mimic neurotransmitter actions of the pedunculopontine nucleus and high frequency stiulation on cultured dissociated rat subthalamic neurons. STN cell models: single and multi compartment, and system level models are discussed in relation to subthalamic function and dysfunction. Part I and II are mutually compared.

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Heida T, Marani E, Usunoff KG. The subthalamic nucleus, part II. London: Springer, 2008. 88 p. (Advances in Anatomy, Embryology and Cell Biology; DTR08-9/part II). https://doi.org/10.1007/978-3-540-79462-2