The Theranostic Path to Personalized Nanomedicine

Benjamin Theek, Larissa Y. Rizzo, Josef Ehling, Fabian Kiessling, Twan Gerardus Gertudis Maria Lammers

Research output: Contribution to journalArticleAcademicpeer-review

31 Citations (Scopus)

Abstract

Advances in nanotechnology and chemical engineering have led to the development of many different drug delivery systems. These 1–100(0)-nm-sized carrier materials aim to increase drug concentrations at the pathological site, while avoiding their accumulation in healthy non-target tissues, thereby improving the balance between the efficacy and the toxicity of systemic (chemo-)therapeutic interventions. An important advantage of such nanocarrier materials is the ease of incorporating both diagnostic and therapeutic entities within a single formulation, enabling them to be used for theranostic purposes. We here describe the basic principles of using nanomaterials for targeting therapeutic and diagnostic agents to pathological sites, and we discuss how nanotheranostics and image-guided drug delivery can be used to personalize nanomedicine treatments.
Original languageUndefined
Pages (from-to)67-76
JournalClinical and translational imaging
Volume2
Issue number1
DOIs
Publication statusPublished - 2014

Keywords

  • METIS-309497
  • IR-95155

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