The Twente Photoacoustic Mammoscope 2: 3D vascular network visualization

Sjoukje M. Schoustra*, Roeland Huijink, Laurens Alink, Tim J.P.M. op 't Root, Daan Sprünken, Daniele Piras, Wouter F. Muller Kobold, Caroline A.H. Klazen, Margreet C. van der Schaaf, Frank M. van den Engh, Wiendelt Steenbergen, Srirang Manohar

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

4 Citations (Scopus)
127 Downloads (Pure)


We present the Twente Photoacoustic Mammoscope 2 (PAM 2) based on a 3D tomographic geometry. A functional optical contrast map of breast vascularization can be obtained in a noninvasive, radiation-free and painless manner. A woman lies prone on a bed with one breast pendant in an imaging tank with water, where 12 curved ultrasound arrays are mounted. Each array extends from chest wall towards the nipple following the contour of the pendant breast, and carries 32 detector elements. The detectors' center frequency is 1 MHz. The breast is illuminated from multiple directions: the ventral side of the breast from the bottom and the areas close to the chest wall from the sides. The excitation wavelengths are 755 nm and 1064 nm. By rotating the imaging tank in between measurements, multiple projections can be obtained, providing a 3D image of the breast after reconstruction by means of a filtered backprojection. So far, breasts of healthy volunteers were imaged. Three-dimensional images of the breast contour, the nipple and blood vessel networks within the breast could be observed with high contrast and unprecedented detail.

Original languageEnglish
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2019
EditorsLihong V. Wang, Alexander A. Oraevsky
Place of PublicationBellingham, WA
Number of pages7
ISBN (Electronic)9781510623989
Publication statusPublished - 27 Feb 2019
EventPhotons Plus Ultrasound: Imaging and Sensing 2019 - The Moscone Center, San Francisco, United States
Duration: 2 Feb 20197 Feb 2019

Publication series

NameProgress in Biomedical Optics and Imaging
PublisherSPIE International Society for Optical Engineering
ISSN (Print)1605-7422
NameProceedings of the SPIE
PublisherSPIE International Society for Optical Engineering
ISSN (Print)0277-786X


ConferencePhotons Plus Ultrasound: Imaging and Sensing 2019
Country/TerritoryUnited States
CitySan Francisco


  • Breast cancer
  • Breast imaging
  • Breast vascularization
  • Photoacoustic imaging
  • Tomography


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