The Twente Photoacoustic Mammoscope: system overview and performance

Srirang Manohar, A. Kharine, Johannes C.G. van Hespen, Johan C.G. van Hespen, Wiendelt Steenbergen, Ton van Leeuwen

Research output: Contribution to journalArticleAcademicpeer-review

183 Citations (Scopus)

Abstract

We present PAM, the Photoacoustic Mammoscope developed at the University of Twente, intended for initial retrospective clinical studies on subjects with breast tumours. A parallel plate geometry has been adopted and the breast will be gently compressed between a glass plate and a flat ultrasound detector matrix. Pulsed light (5 ns) from an Nd:YAG laser will impinge the breast through the glass plate in regions of interest; an appropriate number of the 590 elements of the detector matrix will be activated in succession to record photoacoustic signals. Three-dimensional image reconstruction employs a delay-and-sum beamforming algorithm. We discuss various instrumental aspects and the proposed imaging protocol. Performance studies of the ultrasound detector are presented in terms of sensitivity, frequency response and resolution. Details of the patient–instrument interface are provided. Finally some imaging results on well-characterized breast tissue phantoms with embedded tumour simulating inserts are shown.
Original languageUndefined
Pages (from-to)2543-2557
Number of pages15
JournalPhysics in medicine and biology
Volume50
Issue number11
DOIs
Publication statusPublished - 2005

Keywords

  • IR-58699
  • METIS-224137

Cite this

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abstract = "We present PAM, the Photoacoustic Mammoscope developed at the University of Twente, intended for initial retrospective clinical studies on subjects with breast tumours. A parallel plate geometry has been adopted and the breast will be gently compressed between a glass plate and a flat ultrasound detector matrix. Pulsed light (5 ns) from an Nd:YAG laser will impinge the breast through the glass plate in regions of interest; an appropriate number of the 590 elements of the detector matrix will be activated in succession to record photoacoustic signals. Three-dimensional image reconstruction employs a delay-and-sum beamforming algorithm. We discuss various instrumental aspects and the proposed imaging protocol. Performance studies of the ultrasound detector are presented in terms of sensitivity, frequency response and resolution. Details of the patient–instrument interface are provided. Finally some imaging results on well-characterized breast tissue phantoms with embedded tumour simulating inserts are shown.",
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The Twente Photoacoustic Mammoscope: system overview and performance. / Manohar, Srirang; Kharine, A.; van Hespen, Johannes C.G.; van Hespen, Johan C.G.; Steenbergen, Wiendelt; van Leeuwen, Ton.

In: Physics in medicine and biology, Vol. 50, No. 11, 2005, p. 2543-2557.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - The Twente Photoacoustic Mammoscope: system overview and performance

AU - Manohar, Srirang

AU - Kharine, A.

AU - van Hespen, Johannes C.G.

AU - van Hespen, Johan C.G.

AU - Steenbergen, Wiendelt

AU - van Leeuwen, Ton

PY - 2005

Y1 - 2005

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AB - We present PAM, the Photoacoustic Mammoscope developed at the University of Twente, intended for initial retrospective clinical studies on subjects with breast tumours. A parallel plate geometry has been adopted and the breast will be gently compressed between a glass plate and a flat ultrasound detector matrix. Pulsed light (5 ns) from an Nd:YAG laser will impinge the breast through the glass plate in regions of interest; an appropriate number of the 590 elements of the detector matrix will be activated in succession to record photoacoustic signals. Three-dimensional image reconstruction employs a delay-and-sum beamforming algorithm. We discuss various instrumental aspects and the proposed imaging protocol. Performance studies of the ultrasound detector are presented in terms of sensitivity, frequency response and resolution. Details of the patient–instrument interface are provided. Finally some imaging results on well-characterized breast tissue phantoms with embedded tumour simulating inserts are shown.

KW - IR-58699

KW - METIS-224137

U2 - 10.1088/0031-9155/50/11/007

DO - 10.1088/0031-9155/50/11/007

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SP - 2543

EP - 2557

JO - Physics in medicine and biology

JF - Physics in medicine and biology

SN - 0031-9155

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