The use of 120-nm deep channels for liquid chromatographic separations

Veronika Fekete, David Clicq, Wim de Malsche, Johannes G.E. Gardeniers, Gert Desmet

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The present study reports on the exploration of the separation speed limits of RPLC chromatography in open-tubular channels. Applying the shear-driven chromatography principle in a 120-nm deep open channel, and using an improved detection set-up, the separation of three coumarin dyes was detectable 8 mm downstream of the injection point. At this distance, separation efficiencies of N = 17,900–24,100 plates were obtained at a velocity of 10 mm s−1, corresponding to a plate generation velocity of 21,100 to 28,300 plates per second for the most and least retained component, respectively.
Original languageUndefined
Pages (from-to)2-9
Number of pages8
JournalJournal of chromatography A
Issue number1-2
Publication statusPublished - 2008


  • METIS-247505
  • IR-76301

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