The Use of Finite Element Analyses to Design and Fabricate Three-Dimensional Scaffolds for Skeletal Tissue Engineering

W.J. Hendrikson, Clemens van Blitterswijk, Jeroen Rouwkema, Lorenzo Moroni

    Research output: Contribution to journalReview articleAcademicpeer-review

    12 Citations (Scopus)
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    Abstract

    Computational modeling has been increasingly applied to the field of tissue engineering and regenerative medicine. Where in early days computational models were used to better understand the biomechanical requirements of targeted tissues to be regenerated, recently, more and more models are formulated to combine such biomechanical requirements with cell fate predictions to aid in the design of functional three-dimensional scaffolds. In this review, we highlight how computational modeling has been used to understand the mechanisms behind tissue formation and can be used for more rational and biomimetic scaffold-based tissue regeneration strategies. With a particular focus on musculoskeletal tissues, we discuss recent models attempting to predict cell activity in relation to specific mechanical and physical stimuli that can be applied to them through porous three-dimensional scaffolds. In doing so, we review the most common scaffold fabrication methods, with a critical view on those technologies that offer better properties to be more easily combined with computational modeling. Finally, we discuss how modeling, and in particular finite element analysis, can be used to optimize the design of scaffolds for skeletal tissue regeneration.
    Original languageEnglish
    Article number30
    JournalFrontiers in bioengineering and biotechnology
    Volume5
    DOIs
    Publication statusPublished - 17 May 2017

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    Finite Element Analysis
    Tissue Engineering
    Scaffolds (biology)
    Tissue engineering
    Scaffolds
    Tissue Scaffolds
    Tissue regeneration
    Regeneration
    Tissue
    Biomimetics
    Regenerative Medicine
    Technology
    Finite element method
    Fabrication

    Cite this

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    title = "The Use of Finite Element Analyses to Design and Fabricate Three-Dimensional Scaffolds for Skeletal Tissue Engineering",
    abstract = "Computational modeling has been increasingly applied to the field of tissue engineering and regenerative medicine. Where in early days computational models were used to better understand the biomechanical requirements of targeted tissues to be regenerated, recently, more and more models are formulated to combine such biomechanical requirements with cell fate predictions to aid in the design of functional three-dimensional scaffolds. In this review, we highlight how computational modeling has been used to understand the mechanisms behind tissue formation and can be used for more rational and biomimetic scaffold-based tissue regeneration strategies. With a particular focus on musculoskeletal tissues, we discuss recent models attempting to predict cell activity in relation to specific mechanical and physical stimuli that can be applied to them through porous three-dimensional scaffolds. In doing so, we review the most common scaffold fabrication methods, with a critical view on those technologies that offer better properties to be more easily combined with computational modeling. Finally, we discuss how modeling, and in particular finite element analysis, can be used to optimize the design of scaffolds for skeletal tissue regeneration.",
    author = "W.J. Hendrikson and {van Blitterswijk}, Clemens and Jeroen Rouwkema and Lorenzo Moroni",
    year = "2017",
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    language = "English",
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    journal = "Frontiers in bioengineering and biotechnology",
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    The Use of Finite Element Analyses to Design and Fabricate Three-Dimensional Scaffolds for Skeletal Tissue Engineering. / Hendrikson, W.J.; van Blitterswijk, Clemens; Rouwkema, Jeroen ; Moroni, Lorenzo.

    In: Frontiers in bioengineering and biotechnology, Vol. 5, 30, 17.05.2017.

    Research output: Contribution to journalReview articleAcademicpeer-review

    TY - JOUR

    T1 - The Use of Finite Element Analyses to Design and Fabricate Three-Dimensional Scaffolds for Skeletal Tissue Engineering

    AU - Hendrikson, W.J.

    AU - van Blitterswijk, Clemens

    AU - Rouwkema, Jeroen

    AU - Moroni, Lorenzo

    PY - 2017/5/17

    Y1 - 2017/5/17

    N2 - Computational modeling has been increasingly applied to the field of tissue engineering and regenerative medicine. Where in early days computational models were used to better understand the biomechanical requirements of targeted tissues to be regenerated, recently, more and more models are formulated to combine such biomechanical requirements with cell fate predictions to aid in the design of functional three-dimensional scaffolds. In this review, we highlight how computational modeling has been used to understand the mechanisms behind tissue formation and can be used for more rational and biomimetic scaffold-based tissue regeneration strategies. With a particular focus on musculoskeletal tissues, we discuss recent models attempting to predict cell activity in relation to specific mechanical and physical stimuli that can be applied to them through porous three-dimensional scaffolds. In doing so, we review the most common scaffold fabrication methods, with a critical view on those technologies that offer better properties to be more easily combined with computational modeling. Finally, we discuss how modeling, and in particular finite element analysis, can be used to optimize the design of scaffolds for skeletal tissue regeneration.

    AB - Computational modeling has been increasingly applied to the field of tissue engineering and regenerative medicine. Where in early days computational models were used to better understand the biomechanical requirements of targeted tissues to be regenerated, recently, more and more models are formulated to combine such biomechanical requirements with cell fate predictions to aid in the design of functional three-dimensional scaffolds. In this review, we highlight how computational modeling has been used to understand the mechanisms behind tissue formation and can be used for more rational and biomimetic scaffold-based tissue regeneration strategies. With a particular focus on musculoskeletal tissues, we discuss recent models attempting to predict cell activity in relation to specific mechanical and physical stimuli that can be applied to them through porous three-dimensional scaffolds. In doing so, we review the most common scaffold fabrication methods, with a critical view on those technologies that offer better properties to be more easily combined with computational modeling. Finally, we discuss how modeling, and in particular finite element analysis, can be used to optimize the design of scaffolds for skeletal tissue regeneration.

    U2 - 10.3389/fbioe.2017.00030

    DO - 10.3389/fbioe.2017.00030

    M3 - Review article

    VL - 5

    JO - Frontiers in bioengineering and biotechnology

    JF - Frontiers in bioengineering and biotechnology

    SN - 2296-4185

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    ER -