The use of self-assembled receptor layers in immunosensors

R.P.H. Kooyman, D.J. van den Heuvel, J.W. Drijfhout, G.W. Welling

Research output: Contribution to journalArticleAcademicpeer-review

24 Citations (Scopus)
81 Downloads (Pure)

Abstract

We demonstrate that a self-assembled monolayer consisting of an alkylthiol coupled synthetic peptide adsorbed to a gold substrate results in a sensitive receptor surface for specific recognition of protein molecules. The affinity constant of this binding is comparable with that of an antibody-antigen reaction. Evidence is found that such a receptor surface is capable of reversible binding.
Original languageEnglish
Pages (from-to)913-916
Number of pages4
JournalThin solid films
Volume244
Issue number1-2
DOIs
Publication statusPublished - 1994

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