The value of 18F-FDG PET/CT in diagnosis and during follow-up in 273 patients with chronic Q fever

Ilse J.E. Kouijzer (Corresponding Author), Linda M. Kampschreur, Peter C. Wever, Corneline Hoekstra, Marjo E.E. Van Kasteren, Monique G.L. De Jager-Leclercq, Marrigje H. Nabuurs-Franssen, Marjolijn C.A. Wegdam-Blans, Heidi S.M. Ammerlaan, Jacqueline Buijs, Lioe Fee De Geus-Oei, Wim J.G. Oyen, Chantal P. Bleeker-Rovers

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Abstract

In 1%–5% of all acute Q fever infections, chronic Q fever develops, mostly manifesting as endocarditis, infected aneurysms, or infected vascular prostheses. In this study, we investigated the diagnostic value of 18F-FDG PET/CT in chronic Q fever at diagnosis and during follow-up. Methods: All adult Dutch patients suspected of chronic Q fever who were diagnosed since 2007 were retrospectively included until March 2015, when at least one 18F-FDG PET/CT scan was obtained. Clinical data and results from 18F-FDG PET/CT at diagnosis and during follow-up were collected. 18F-FDG PET/CT scans were prospectively reevaluated by 3 nuclear medicine physicians using a structured scoring system. Results: In total, 273 patients with possible, probable, or proven chronic Q fever were included. Of all 18F-FDG PET/CT scans performed at diagnosis, 13.5% led to a change in diagnosis. Q fever–related mortality rate in patients with and without vascular infection based on 18F-FDG PET/CT was 23.8% and 2.1%, respectively (P 5 0.001). When 18F-FDG PET/CT was added as a major criterion to the modified Duke criteria, 17 patients (1.9-fold increase) had definite endocarditis. At diagnosis, 19.6% of 18F-FDG PET/CT scans led to treatment modification. During follow-up, 57.3% of 18F-FDG PET/CT scans resulted in treatment modification. Conclusion: 18F-FDG PET/CT is a valuable technique in diagnosis of chronic Q fever and during follow-up, often leading to a change in diagnosis or treatment modification and providing important prognostic information on patient survival.

Original languageEnglish
Pages (from-to)127-133
Number of pages7
JournalJournal of nuclear medicine
Volume59
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018

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Q Fever
Fluorodeoxyglucose F18
Endocarditis
Blood Vessel Prosthesis
Infected Aneurysm
Nuclear Medicine
Infection
Blood Vessels
Therapeutics
Positron Emission Tomography Computed Tomography
Physicians

Keywords

  • 18F-FDG PET/CT
  • Endocarditis
  • Q fever
  • Vascular infection

Cite this

Kouijzer, I. J. E., Kampschreur, L. M., Wever, P. C., Hoekstra, C., Van Kasteren, M. E. E., De Jager-Leclercq, M. G. L., ... Bleeker-Rovers, C. P. (2018). The value of 18F-FDG PET/CT in diagnosis and during follow-up in 273 patients with chronic Q fever. Journal of nuclear medicine, 59(1), 127-133. https://doi.org/10.2967/jnumed.117.192492
Kouijzer, Ilse J.E. ; Kampschreur, Linda M. ; Wever, Peter C. ; Hoekstra, Corneline ; Van Kasteren, Marjo E.E. ; De Jager-Leclercq, Monique G.L. ; Nabuurs-Franssen, Marrigje H. ; Wegdam-Blans, Marjolijn C.A. ; Ammerlaan, Heidi S.M. ; Buijs, Jacqueline ; De Geus-Oei, Lioe Fee ; Oyen, Wim J.G. ; Bleeker-Rovers, Chantal P. / The value of 18F-FDG PET/CT in diagnosis and during follow-up in 273 patients with chronic Q fever. In: Journal of nuclear medicine. 2018 ; Vol. 59, No. 1. pp. 127-133.
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title = "The value of 18F-FDG PET/CT in diagnosis and during follow-up in 273 patients with chronic Q fever",
abstract = "In 1{\%}–5{\%} of all acute Q fever infections, chronic Q fever develops, mostly manifesting as endocarditis, infected aneurysms, or infected vascular prostheses. In this study, we investigated the diagnostic value of 18F-FDG PET/CT in chronic Q fever at diagnosis and during follow-up. Methods: All adult Dutch patients suspected of chronic Q fever who were diagnosed since 2007 were retrospectively included until March 2015, when at least one 18F-FDG PET/CT scan was obtained. Clinical data and results from 18F-FDG PET/CT at diagnosis and during follow-up were collected. 18F-FDG PET/CT scans were prospectively reevaluated by 3 nuclear medicine physicians using a structured scoring system. Results: In total, 273 patients with possible, probable, or proven chronic Q fever were included. Of all 18F-FDG PET/CT scans performed at diagnosis, 13.5{\%} led to a change in diagnosis. Q fever–related mortality rate in patients with and without vascular infection based on 18F-FDG PET/CT was 23.8{\%} and 2.1{\%}, respectively (P 5 0.001). When 18F-FDG PET/CT was added as a major criterion to the modified Duke criteria, 17 patients (1.9-fold increase) had definite endocarditis. At diagnosis, 19.6{\%} of 18F-FDG PET/CT scans led to treatment modification. During follow-up, 57.3{\%} of 18F-FDG PET/CT scans resulted in treatment modification. Conclusion: 18F-FDG PET/CT is a valuable technique in diagnosis of chronic Q fever and during follow-up, often leading to a change in diagnosis or treatment modification and providing important prognostic information on patient survival.",
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author = "Kouijzer, {Ilse J.E.} and Kampschreur, {Linda M.} and Wever, {Peter C.} and Corneline Hoekstra and {Van Kasteren}, {Marjo E.E.} and {De Jager-Leclercq}, {Monique G.L.} and Nabuurs-Franssen, {Marrigje H.} and Wegdam-Blans, {Marjolijn C.A.} and Ammerlaan, {Heidi S.M.} and Jacqueline Buijs and {De Geus-Oei}, {Lioe Fee} and Oyen, {Wim J.G.} and Bleeker-Rovers, {Chantal P.}",
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Kouijzer, IJE, Kampschreur, LM, Wever, PC, Hoekstra, C, Van Kasteren, MEE, De Jager-Leclercq, MGL, Nabuurs-Franssen, MH, Wegdam-Blans, MCA, Ammerlaan, HSM, Buijs, J, De Geus-Oei, LF, Oyen, WJG & Bleeker-Rovers, CP 2018, 'The value of 18F-FDG PET/CT in diagnosis and during follow-up in 273 patients with chronic Q fever' Journal of nuclear medicine, vol. 59, no. 1, pp. 127-133. https://doi.org/10.2967/jnumed.117.192492

The value of 18F-FDG PET/CT in diagnosis and during follow-up in 273 patients with chronic Q fever. / Kouijzer, Ilse J.E. (Corresponding Author); Kampschreur, Linda M.; Wever, Peter C.; Hoekstra, Corneline; Van Kasteren, Marjo E.E.; De Jager-Leclercq, Monique G.L.; Nabuurs-Franssen, Marrigje H.; Wegdam-Blans, Marjolijn C.A.; Ammerlaan, Heidi S.M.; Buijs, Jacqueline; De Geus-Oei, Lioe Fee; Oyen, Wim J.G.; Bleeker-Rovers, Chantal P.

In: Journal of nuclear medicine, Vol. 59, No. 1, 01.01.2018, p. 127-133.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - The value of 18F-FDG PET/CT in diagnosis and during follow-up in 273 patients with chronic Q fever

AU - Kouijzer, Ilse J.E.

AU - Kampschreur, Linda M.

AU - Wever, Peter C.

AU - Hoekstra, Corneline

AU - Van Kasteren, Marjo E.E.

AU - De Jager-Leclercq, Monique G.L.

AU - Nabuurs-Franssen, Marrigje H.

AU - Wegdam-Blans, Marjolijn C.A.

AU - Ammerlaan, Heidi S.M.

AU - Buijs, Jacqueline

AU - De Geus-Oei, Lioe Fee

AU - Oyen, Wim J.G.

AU - Bleeker-Rovers, Chantal P.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - In 1%–5% of all acute Q fever infections, chronic Q fever develops, mostly manifesting as endocarditis, infected aneurysms, or infected vascular prostheses. In this study, we investigated the diagnostic value of 18F-FDG PET/CT in chronic Q fever at diagnosis and during follow-up. Methods: All adult Dutch patients suspected of chronic Q fever who were diagnosed since 2007 were retrospectively included until March 2015, when at least one 18F-FDG PET/CT scan was obtained. Clinical data and results from 18F-FDG PET/CT at diagnosis and during follow-up were collected. 18F-FDG PET/CT scans were prospectively reevaluated by 3 nuclear medicine physicians using a structured scoring system. Results: In total, 273 patients with possible, probable, or proven chronic Q fever were included. Of all 18F-FDG PET/CT scans performed at diagnosis, 13.5% led to a change in diagnosis. Q fever–related mortality rate in patients with and without vascular infection based on 18F-FDG PET/CT was 23.8% and 2.1%, respectively (P 5 0.001). When 18F-FDG PET/CT was added as a major criterion to the modified Duke criteria, 17 patients (1.9-fold increase) had definite endocarditis. At diagnosis, 19.6% of 18F-FDG PET/CT scans led to treatment modification. During follow-up, 57.3% of 18F-FDG PET/CT scans resulted in treatment modification. Conclusion: 18F-FDG PET/CT is a valuable technique in diagnosis of chronic Q fever and during follow-up, often leading to a change in diagnosis or treatment modification and providing important prognostic information on patient survival.

AB - In 1%–5% of all acute Q fever infections, chronic Q fever develops, mostly manifesting as endocarditis, infected aneurysms, or infected vascular prostheses. In this study, we investigated the diagnostic value of 18F-FDG PET/CT in chronic Q fever at diagnosis and during follow-up. Methods: All adult Dutch patients suspected of chronic Q fever who were diagnosed since 2007 were retrospectively included until March 2015, when at least one 18F-FDG PET/CT scan was obtained. Clinical data and results from 18F-FDG PET/CT at diagnosis and during follow-up were collected. 18F-FDG PET/CT scans were prospectively reevaluated by 3 nuclear medicine physicians using a structured scoring system. Results: In total, 273 patients with possible, probable, or proven chronic Q fever were included. Of all 18F-FDG PET/CT scans performed at diagnosis, 13.5% led to a change in diagnosis. Q fever–related mortality rate in patients with and without vascular infection based on 18F-FDG PET/CT was 23.8% and 2.1%, respectively (P 5 0.001). When 18F-FDG PET/CT was added as a major criterion to the modified Duke criteria, 17 patients (1.9-fold increase) had definite endocarditis. At diagnosis, 19.6% of 18F-FDG PET/CT scans led to treatment modification. During follow-up, 57.3% of 18F-FDG PET/CT scans resulted in treatment modification. Conclusion: 18F-FDG PET/CT is a valuable technique in diagnosis of chronic Q fever and during follow-up, often leading to a change in diagnosis or treatment modification and providing important prognostic information on patient survival.

KW - 18F-FDG PET/CT

KW - Endocarditis

KW - Q fever

KW - Vascular infection

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U2 - 10.2967/jnumed.117.192492

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Kouijzer IJE, Kampschreur LM, Wever PC, Hoekstra C, Van Kasteren MEE, De Jager-Leclercq MGL et al. The value of 18F-FDG PET/CT in diagnosis and during follow-up in 273 patients with chronic Q fever. Journal of nuclear medicine. 2018 Jan 1;59(1):127-133. https://doi.org/10.2967/jnumed.117.192492