Theoretical analysis of human muscle membrane behaviour in hypokalemic periodic paralysis

Martin J. Alberink, Willemien Wallinga, Henk Wolters, Dirk L. Ypey, Thera P. Links, Herman B.K. Boom

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    Abstract

    Computer simulations were performed to investigate the behavior of human muscle membrane with membrane defects supposed to be present in the muscular disease Hypokalemic Periodic Paralysis (HOPP). The model used for simulation was a Hodgkin-Huxley model. The T-tubular system was also incorporated. It was studied whether the membrane defects caused the following recorded HOPP phenomena: a slight depolarization of a HOPP muscle cell when serum potassium is normal and a strong depolarization to -50 mV when serum potassium is low. In the authors' model a constant small sodium leak conductance slightly depolarized the cell, whereas a small fraction of noninactivating sodium channels caused a strong depolarization. In the case of a dependency of this fraction on serum potassium according to a Boltzmann relation such a depolarization occurred only when serum potassium was low. In the authors' simulations, the resting membrane potential moved from -90 mV to -30 mV after a single action potential when 8%, or more of the sodium channels did not inactivate. The authors' results were qualitatively similar when the T-tubular system was decoupled
    Original languageEnglish
    Title of host publicationProceedings 17th International Conference of the Engineering in Medicine and Biology Society, IEE/EMBS 1995
    PublisherIEEE
    Pages1493-1494
    Number of pages2
    Volume2
    ISBN (Print)9780780324756
    DOIs
    Publication statusPublished - 20 Sep 1995
    Event30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2008 - Vancouver, Canada
    Duration: 20 Aug 200825 Aug 2008
    Conference number: 30

    Conference

    Conference30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2008
    Abbreviated titleEMBC
    CountryCanada
    CityVancouver
    Period20/08/0825/08/08

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