Therapeutic drug monitoring of monoclonal antibodies in inflammatory and malignant disease: translating TNF-α experience to oncology

T.H. Oude Munnink, M.J. Henstra, Loes Irene Segerink, K.L.L. Movig, P. Brummelhuis-Visser

    Research output: Contribution to journalArticleAcademicpeer-review

    36 Citations (Scopus)

    Abstract

    Lack of response to monoclonal antibodies (mAbs) has been associated with inadequatemAb serumconcentrations. Therapeutic drugmonitoring (TDM) of mAbs has the potential to guide to more effective dosing in individual patients. This review discusses the mechanisms responsible for interpatient variability ofmAb pharmacokinetics, summarizes exposureresponse data of mAbs used in inflammatory and malignant disease, presents current evidence of mAb-TDM in inflammatory disease, and provides hurdles and required future steps for further implementingmAb-TDM.
    Original languageUndefined
    Pages (from-to)419-431
    Number of pages13
    JournalClinical pharmacology & therapeutics
    Volume99
    Issue number4
    DOIs
    Publication statusPublished - Apr 2016

    Keywords

    • EWI-27101
    • IR-99204
    • METIS-315547

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