Therapeutic drug monitoring of monoclonal antibodies in inflammatory and malignant disease: translating TNF-α experience to oncology

T.H. Oude Munnink; M.J. Henstra; Loes Irene Segerink; K.L.L. Movig; P. Brummelhuis-Visser

doi:10.1002/cpt.211

Therapeutic drug monitoring of monoclonal antibodies in inflammatory and malignant disease: translating TNF-α experience to oncology

T.H. Oude Munnink, M.J. Henstra, Loes Irene Segerink, K.L.L. Movig, P. Brummelhuis-Visser

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Lack of response to monoclonal antibodies (mAbs) has been associated with inadequatemAb serumconcentrations. Therapeutic drugmonitoring (TDM) of mAbs has the potential to guide to more effective dosing in individual patients. This review discusses the mechanisms responsible for interpatient variability ofmAb pharmacokinetics, summarizes exposureresponse data of mAbs used in inflammatory and malignant disease, presents current evidence of mAb-TDM in inflammatory disease, and provides hurdles and required future steps for further implementingmAb-TDM.

Original language	Undefined
Pages (from-to)	419-431
Number of pages	13
Journal	Clinical pharmacology & therapeutics
Volume	99
Issue number	4
DOIs	https://doi.org/10.1002/cpt.211
Publication status	Published - Apr 2016

Keywords

EWI-27101
IR-99204
METIS-315547

Access to Document

10.1002/cpt.211

http://eprints.eemcs.utwente.nl/secure2/27101/01/Oude_Munnink_et_al-2016-Clinical_Pharmacology_&_Therapeutics.pdf

Cite this

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AU - Movig, K.L.L.

AU - Brummelhuis-Visser, P.

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AB - Lack of response to monoclonal antibodies (mAbs) has been associated with inadequatemAb serumconcentrations. Therapeutic drugmonitoring (TDM) of mAbs has the potential to guide to more effective dosing in individual patients. This review discusses the mechanisms responsible for interpatient variability ofmAb pharmacokinetics, summarizes exposureresponse data of mAbs used in inflammatory and malignant disease, presents current evidence of mAb-TDM in inflammatory disease, and provides hurdles and required future steps for further implementingmAb-TDM.

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