Thermally exfoliated graphene oxide reinforced fluorinated pentablock poly(l -lactide-co-ε-caprolactone) electrospun scaffolds: Insight into antimicrobial activity and biodegradation

Burcu Saner Okan* (Corresponding Author), Azucena Marset, Jamal Seyyed Monfared Zanjani, Pinar Akkus Sut, Ozlem Sen, Mustafa Çulha, Yusuf Menceloglu

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Abstract

Three-dimensional fluorinated pentablock poly(l-lactide-co-ε-caprolactone)-based scaffolds were successfully produced by the incorporation of thermally exfoliated graphene oxide (TEGO) as an antimicrobial agent with an electrospinning technique. In a ring-opening polymerization, the fluorinated groups in the middle of polymer backbone were attached with a perfluorinated reactive stabilizer having oxygen-carrying ability. The fiber diameter and its morphologies were optimized through changes in TEGO amount, voltage, polymer concentration, and solvent type to obtain an ideal scaffold structure. Instead of the widely used graphene oxide synthesized by Hummer's method, TEGO sheets having a low amount of oxygen produced by thermal expansion were integrated into the fiber structure to investigate the effect of the oxygen functional groups of TEGO sheets on the degradation and antimicrobial activity of the scaffolds. There was no antimicrobial activity in TEGO-reinforced scaffolds in the in vitro tests in contrast to the literature. This study confirmed that a low number of oxygen functional groups on the surface of TEGO restricted the antimicrobial activity of the fabricated composite scaffolds.

Original languageEnglish
Article number43490
JournalJournal of applied polymer science
Volume133
Issue number22
DOIs
Publication statusPublished - 10 Jun 2016
Externally publishedYes

Keywords

  • biodegradable
  • copolymers
  • electrospinning
  • graphene and fullerenes
  • nanotubes
  • surfaces and interfaces

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