Thermo-sensitive transition of monomethodoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) films to micellar-like nanoparticles

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Abstract

Monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) (mPEG3–PTMC11, Mn of mPEG = 3.1 × 103 and Mn of PTMC = 10.8 × 103 g/mol) was synthesized by ring-opening polymerization of TMC using mPEG3 as an initiator and stannous octoate as a catalyst. The block copolymer has a broad melting range with a peak at 49.5 °C and a heat of fusion of 47.6 J/g. The heat of fusion normalized to the mPEG content is higher than that of the mPEG3 polymer, suggesting that PTMC segments are also semi-crystalline. The mPEG3–PTMC11 films were stable in water at room temperature, whereas at 37 °C the film specimens disintegrated and the amphiphilic block copolymer self-assembled into micellar-like nanoparticles with average sizes up to 210 nm. The critical association concentration (CAC) of the formed micellar-like particles is 1.35 × 10− 3 mg/ml. The average size and polydispersity index of the formed mPEG3–PTMC11 nanoparticles depend on temperature and storage time: the values decrease with increases in temperature and in storage time. By co-dissolving dexamethasone with mPEG3–PTMC11 during the film preparation, micellar-like nanoparticles loaded with dexamethasone can be obtained after the film to micellar-like nanoparticles transition. A high loading efficiency of 93.3 wt.% was achieved. The sustained release of the drug was complete in 20 d.
Original languageEnglish
Pages (from-to)57-63
JournalJournal of controlled release
Volume112
Issue number1
DOIs
Publication statusPublished - 2006

Keywords

  • Poly(trimethylene carbonate)
  • Micelles
  • Drug delivery
  • Amphiphilic block copolymers

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