Three-dimensional Mach-Zehnder interferometer in a microfluidic chip for spatially-resolved label-free detection

Andrea Crespi, Yu Gu, Bongkot Ngamson, Hugo Hoekstra, C. Dongre, Markus Pollnau, Roberta Ramponi, Hans H. van den Vlekkert, Paul Watts, Giulio Cerullo, Roberto Osellame

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    192 Citations (Scopus)
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    Ultrafast laser writing of waveguides in glasses is a very flexible and simple method for direct on-chip integration of photonic devices. In this work we present a monolithic optofluidic device in fused silica providing label-free and spatially-resolved sensing in a microfluidic channel. A Mach-Zehnder interferometer is inscribed with the sensing arm orthogonally crossing the microfluidic channel and the reference arm passing over it. The interferometer is integrated either with a microchannel fabricated by femtosecond laser technology or into a commercial lab-on-chip for capillary electrophoresis. The device layout, made possible by the unique three-dimensional capabilities of the technique, enables label-free sensing of samples flowing in the microchannel with spatial resolution of about 10 um and limit of detection down to 10e-4 RIU.
    Original languageEnglish
    Pages (from-to)1167-1173
    Number of pages7
    JournalLab on a chip
    Issue number9
    Publication statusPublished - Apr 2010


    • EC Grant Agreement nr.: FP6/034562


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