Three-dimensional photoacoustic imaging of blood vessels in tissue

C.G.A. Hoelen, F.F.M. de Mul, R. Pongers, A. Dekker

    Research output: Contribution to journalArticleAcademicpeer-review

    447 Citations (Scopus)


    We applied photoacoustics as a tissue tomography technique for the detection of blood concentrations, e.g., angiogenesis around tumors. We imaged blood vessels in highly scattering samples, using 532-nm light, to depths of ,1 cm. The samples were real tissue (chicken breast) or 10% dilutions of Intralipid-10%. The blood flowed through nylon capillaries. Polyvinylidene difluoride (PVdF) piezoelectric detectors were used in a surface-scanning mode. We demonstrate the sensitivity of the technique by photoacoustic detection of single red blood cells upon a glass plate. Lateral resolution is limited by the detector diameter s200 mmd. The depth resolution is ,10 mm.
    Original languageEnglish
    Pages (from-to)648-650
    Number of pages3
    JournalOptics letters
    Issue number8
    Publication statusPublished - 1998


    • METIS-129324
    • IR-71731


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