Three-dimensional photoacoustic imaging of blood vessels in tissue

C.G.A. Hoelen; F.F.M. de Mul; R. Pongers; A. Dekker

doi:10.1364/OL.23.000648

Three-dimensional photoacoustic imaging of blood vessels in tissue

C.G.A. Hoelen, F.F.M. de Mul, R. Pongers, A. Dekker

Research output: Contribution to journal › Article › Academic › peer-review

447 Citations (Scopus)

Abstract

We applied photoacoustics as a tissue tomography technique for the detection of blood concentrations, e.g., angiogenesis around tumors. We imaged blood vessels in highly scattering samples, using 532-nm light, to depths of ,1 cm. The samples were real tissue (chicken breast) or 10% dilutions of Intralipid-10%. The blood flowed through nylon capillaries. Polyvinylidene difluoride (PVdF) piezoelectric detectors were used in a surface-scanning mode. We demonstrate the sensitivity of the technique by photoacoustic detection of single red blood cells upon a glass plate. Lateral resolution is limited by the detector diameter s200 mmd. The depth resolution is ,10 mm.

Original language	English
Pages (from-to)	648-650
Number of pages	3
Journal	Optics letters
Volume	23
Issue number	8
DOIs	https://doi.org/10.1364/OL.23.000648
Publication status	Published - 1998

Keywords

METIS-129324
IR-71731

Access to Document

10.1364/OL.23.000648

Cite this

@article{ccbe9b26510e430580e59da515791035,

title = "Three-dimensional photoacoustic imaging of blood vessels in tissue",

abstract = "We applied photoacoustics as a tissue tomography technique for the detection of blood concentrations, e.g., angiogenesis around tumors. We imaged blood vessels in highly scattering samples, using 532-nm light, to depths of ,1 cm. The samples were real tissue (chicken breast) or 10% dilutions of Intralipid-10%. The blood flowed through nylon capillaries. Polyvinylidene difluoride (PVdF) piezoelectric detectors were used in a surface-scanning mode. We demonstrate the sensitivity of the technique by photoacoustic detection of single red blood cells upon a glass plate. Lateral resolution is limited by the detector diameter s200 mmd. The depth resolution is ,10 mm.",

keywords = "METIS-129324, IR-71731",

author = "C.G.A. Hoelen and {de Mul}, F.F.M. and R. Pongers and A. Dekker",

year = "1998",

doi = "10.1364/OL.23.000648",

language = "English",

volume = "23",

pages = "648--650",

journal = "Optics letters",

issn = "0146-9592",

publisher = "The Optical Society",

number = "8",

}

TY - JOUR

T1 - Three-dimensional photoacoustic imaging of blood vessels in tissue

AU - Hoelen, C.G.A.

AU - de Mul, F.F.M.

AU - Pongers, R.

AU - Dekker, A.

PY - 1998

Y1 - 1998

N2 - We applied photoacoustics as a tissue tomography technique for the detection of blood concentrations, e.g., angiogenesis around tumors. We imaged blood vessels in highly scattering samples, using 532-nm light, to depths of ,1 cm. The samples were real tissue (chicken breast) or 10% dilutions of Intralipid-10%. The blood flowed through nylon capillaries. Polyvinylidene difluoride (PVdF) piezoelectric detectors were used in a surface-scanning mode. We demonstrate the sensitivity of the technique by photoacoustic detection of single red blood cells upon a glass plate. Lateral resolution is limited by the detector diameter s200 mmd. The depth resolution is ,10 mm.

AB - We applied photoacoustics as a tissue tomography technique for the detection of blood concentrations, e.g., angiogenesis around tumors. We imaged blood vessels in highly scattering samples, using 532-nm light, to depths of ,1 cm. The samples were real tissue (chicken breast) or 10% dilutions of Intralipid-10%. The blood flowed through nylon capillaries. Polyvinylidene difluoride (PVdF) piezoelectric detectors were used in a surface-scanning mode. We demonstrate the sensitivity of the technique by photoacoustic detection of single red blood cells upon a glass plate. Lateral resolution is limited by the detector diameter s200 mmd. The depth resolution is ,10 mm.

KW - METIS-129324

KW - IR-71731

U2 - 10.1364/OL.23.000648

DO - 10.1364/OL.23.000648

M3 - Article

VL - 23

SP - 648

EP - 650

JO - Optics letters

JF - Optics letters

SN - 0146-9592

IS - 8

ER -

Three-dimensional photoacoustic imaging of blood vessels in tissue

Abstract

Keywords

Access to Document

Fingerprint

Cite this