Threshold behavior of vibrating microbubbles

M. Emmer*, A. Van Wamel, D. E. Goertz, M. Versluis, N. De Jong

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

3 Citations (Scopus)

Abstract

For individual phospholipid-coated microbubbles with a diameter smaller than 5 μm, highspeed camera recordings revealed threshold behavior in the onset of vibration. Previous studies showed a pressure-dependent attenuation for phospholipid-coated microbubbles. The aim of this study was to investigate if there is a relationship between microbubble threshold behavior and pressure-dependent attenuation. At a rising acoustic pressure from 5 to 200 kPa, the attenuation of BR14 increased linearly from 4.5 dB to 7 dB. In contrast to BR14, Levovist did not show pressure-dependent attenuation. For BR14 smaller than 3 μm diameter, attenuation increased from 4 to 12 dB. However, up to 50 kPa no increase of attenuation was observed. These observations can be explained by phospholipid-coated bubble threshold behavior. When the acoustic pressure increases above a threshold acoustic pressure, microbubbles smaller than 5 μm start to oscillate and contribute to the attenuation. Levovist is considered to be a free microbubble, for which threshold behavior is not expected. An imaging technique such as power modulation imaging could profit from the presence of an acoustic pressure threshold.

Original languageEnglish
Title of host publication2006 IEEE International Ultrasonics Symposium, IUS
Pages1545-1547
Number of pages3
DOIs
Publication statusPublished - 1 Dec 2006

Publication series

NameProceedings - IEEE Ultrasonics Symposium
Volume1
ISSN (Print)1051-0117

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